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Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 2000 Jul;59(7):506–511. doi: 10.1136/ard.59.7.506

Synovial biopsy in arthritis research: five years of concerted European collaboration

B Bresnihan 1, P P Tak 1, P Emery 1, L Klareskog 1, F Breedveld 1
PMCID: PMC1753183  PMID: 10873958

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Selected References

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  1. Allard S. A., Bayliss M. T., Maini R. N. The synovium-cartilage junction of the normal human knee. Implications for joint destruction and repair. Arthritis Rheum. 1990 Aug;33(8):1170–1179. doi: 10.1002/art.1780330818. [DOI] [PubMed] [Google Scholar]
  2. Arnold W. J. Office-based arthroscopy. Bull Rheum Dis. 1992 Aug;41(5):3–6. [PubMed] [Google Scholar]
  3. Ayral X., Dougados M., Listrat V., Bonvarlet J. P., Simonnet J., Amor B. Arthroscopic evaluation of chondropathy in osteoarthritis of the knee. J Rheumatol. 1996 Apr;23(4):698–706. [PubMed] [Google Scholar]
  4. Bresnihan B., Cunnane G., Youssef P., Yanni G., Fitzgerald O., Mulherin D. Microscopic measurement of synovial membrane inflammation in rheumatoid arthritis: proposals for the evaluation of tissue samples by quantitative analysis. Br J Rheumatol. 1998 Jun;37(6):636–642. doi: 10.1093/rheumatology/37.6.636. [DOI] [PubMed] [Google Scholar]
  5. Bresnihan B., Tak P. P. Synovial tissue analysis in rheumatoid arthritis. Baillieres Best Pract Res Clin Rheumatol. 1999 Dec;13(4):645–659. doi: 10.1053/berh.1999.0051. [DOI] [PubMed] [Google Scholar]
  6. Burmester G. R., Jahn B., Rohwer P., Zacher J., Winchester R. J., Kalden J. R. Differential expression of Ia antigens by rheumatoid synovial lining cells. J Clin Invest. 1987 Sep;80(3):595–604. doi: 10.1172/JCI113111. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Burmester G. R., Stuhlmüller B., Keyszer G., Kinne R. W. Mononuclear phagocytes and rheumatoid synovitis. Mastermind or workhorse in arthritis? Arthritis Rheum. 1997 Jan;40(1):5–18. doi: 10.1002/art.1780400104. [DOI] [PubMed] [Google Scholar]
  8. CRUICKSHANK B. Interpretation of multiple biopsies of synovial tissue in rheumatic diseases. Ann Rheum Dis. 1952 Jun;11(2):137–145. doi: 10.1136/ard.11.2.137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Chang R. W., Sharma L. Why a rheumatologist should be interested in arthroscopy. Arthritis Rheum. 1994 Nov;37(11):1573–1576. doi: 10.1002/art.1780371102. [DOI] [PubMed] [Google Scholar]
  10. Chu C. Q., Field M., Feldmann M., Maini R. N. Localization of tumor necrosis factor alpha in synovial tissues and at the cartilage-pannus junction in patients with rheumatoid arthritis. Arthritis Rheum. 1991 Sep;34(9):1125–1132. doi: 10.1002/art.1780340908. [DOI] [PubMed] [Google Scholar]
  11. Cunnane G., Bjork L., Ulfgren A. K., Lindblad S., FitzGerald O., Bresnihan B., Andersson U. Quantitative analysis of synovial membrane inflammation: a comparison between automated and conventional microscopic measurements. Ann Rheum Dis. 1999 Aug;58(8):493–499. doi: 10.1136/ard.58.8.493. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Cunnane G., FitzGerald O., Hummel K. M., Gay R. E., Gay S., Bresnihan B. Collagenase, cathepsin B and cathepsin L gene expression in the synovial membrane of patients with early inflammatory arthritis. Rheumatology (Oxford) 1999 Jan;38(1):34–42. doi: 10.1093/rheumatology/38.1.34. [DOI] [PubMed] [Google Scholar]
  13. Dayer J. M., Beutler B., Cerami A. Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts. J Exp Med. 1985 Dec 1;162(6):2163–2168. doi: 10.1084/jem.162.6.2163. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Dolhain R. J., Tak P. P., Dijkmans B. A., De Kuiper P., Breedveld F. C., Miltenburg A. M. Methotrexate reduces inflammatory cell numbers, expression of monokines and of adhesion molecules in synovial tissue of patients with rheumatoid arthritis. Br J Rheumatol. 1998 May;37(5):502–508. doi: 10.1093/rheumatology/37.5.502. [DOI] [PubMed] [Google Scholar]
  15. Dolhain R. J., Ter Haar N. T., De Kuiper R., Nieuwenhuis I. G., Zwinderman A. H., Breedveld F. C., Miltenburg A. M. Distribution of T cells and signs of T-cell activation in the rheumatoid joint: implications for semiquantitative comparative histology. Br J Rheumatol. 1998 Mar;37(3):324–330. doi: 10.1093/rheumatology/37.3.324. [DOI] [PubMed] [Google Scholar]
  16. Emery P. The Roche Rheumatology Prize Lecture. The optimal management of early rheumatoid disease: the key to preventing disability. Br J Rheumatol. 1994 Aug;33(8):765–768. doi: 10.1093/rheumatology/33.8.765. [DOI] [PubMed] [Google Scholar]
  17. Evanson J. M., Jeffrey J. J., Krane S. M. Human collagenase: identification and characterization of an enzyme from rheumatoid synovium in culture. Science. 1967 Oct 27;158(3800):499–502. doi: 10.1126/science.158.3800.499. [DOI] [PubMed] [Google Scholar]
  18. Fassbender H. G. Histomorphological basis of articular cartilage destruction in rheumatoid arthritis. Coll Relat Res. 1983 Mar;3(2):141–155. doi: 10.1016/s0174-173x(83)80040-5. [DOI] [PubMed] [Google Scholar]
  19. Firestein G. S., Alvaro-Gracia J. M., Maki R., Alvaro-Garcia J. M. Quantitative analysis of cytokine gene expression in rheumatoid arthritis. J Immunol. 1990 May 1;144(9):3347–3353. [PubMed] [Google Scholar]
  20. Firestein G. S. Invasive fibroblast-like synoviocytes in rheumatoid arthritis. Passive responders or transformed aggressors? Arthritis Rheum. 1996 Nov;39(11):1781–1790. doi: 10.1002/art.1780391103. [DOI] [PubMed] [Google Scholar]
  21. Firestein G. S., Paine M. M., Boyle D. L. Mechanisms of methotrexate action in rheumatoid arthritis. Selective decrease in synovial collagenase gene expression. Arthritis Rheum. 1994 Feb;37(2):193–200. doi: 10.1002/art.1780370207. [DOI] [PubMed] [Google Scholar]
  22. Firestein G. S., Paine M. M., Littman B. H. Gene expression (collagenase, tissue inhibitor of metalloproteinases, complement, and HLA-DR) in rheumatoid arthritis and osteoarthritis synovium. Quantitative analysis and effect of intraarticular corticosteroids. Arthritis Rheum. 1991 Sep;34(9):1094–1105. doi: 10.1002/art.1780340905. [DOI] [PubMed] [Google Scholar]
  23. Firestein G. S., Yeo M., Zvaifler N. J. Apoptosis in rheumatoid arthritis synovium. J Clin Invest. 1995 Sep;96(3):1631–1638. doi: 10.1172/JCI118202. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. FitzGerald O., Soden M., Yanni G., Robinson R., Bresnihan B. Morphometric analysis of blood vessels in synovial membranes obtained from clinically affected and unaffected knee joints of patients with rheumatoid arthritis. Ann Rheum Dis. 1991 Nov;50(11):792–796. doi: 10.1136/ard.50.11.792. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Gravallese E. M., Darling J. M., Ladd A. L., Katz J. N., Glimcher L. H. In situ hybridization studies of stromelysin and collagenase messenger RNA expression in rheumatoid synovium. Arthritis Rheum. 1991 Sep;34(9):1076–1084. doi: 10.1002/art.1780340903. [DOI] [PubMed] [Google Scholar]
  26. Gravallese E. M., Harada Y., Wang J. T., Gorn A. H., Thornhill T. S., Goldring S. R. Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis. Am J Pathol. 1998 Apr;152(4):943–951. [PMC free article] [PubMed] [Google Scholar]
  27. Hamann J., Wishaupt J. O., van Lier R. A., Smeets T. J., Breedveld F. C., Tak P. P. Expression of the activation antigen CD97 and its ligand CD55 in rheumatoid synovial tissue. Arthritis Rheum. 1999 Apr;42(4):650–658. doi: 10.1002/1529-0131(199904)42:4<650::AID-ANR7>3.0.CO;2-S. [DOI] [PubMed] [Google Scholar]
  28. Henderson D. R., Jayson M. I., Tribe C. R. Lack of correlation of synovial histology with joint damage in rheumatoid arthritis. Ann Rheum Dis. 1975 Feb;34(1):7–11. doi: 10.1136/ard.34.1.7. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Hutton C. W., Hinton C., Dieppe P. A. Intra-articular variation of synovial changes in knee arthritis: biopsy study comparing changes in patellofemoral synovium and the medial tibiofemoral synovium. Br J Rheumatol. 1987 Feb;26(1):5–8. doi: 10.1093/rheumatology/26.1.5. [DOI] [PubMed] [Google Scholar]
  30. Iguchi T., Kurosaka M., Ziff M. Electron microscopic study of HLA-DR and monocyte/macrophage staining cells in the rheumatoid synovial membrane. Arthritis Rheum. 1986 May;29(5):600–613. doi: 10.1002/art.1780290504. [DOI] [PubMed] [Google Scholar]
  31. Ishikawa H., Ziff M. Electron microscopic observations of immunoreactive cells in the rheumatoid synovial membrane. Arthritis Rheum. 1976 Jan-Feb;19(1):1–14. doi: 10.1002/art.1780190101. [DOI] [PubMed] [Google Scholar]
  32. Janossy G., Panayi G., Duke O., Bofill M., Poulter L. W., Goldstein G. Rheumatoid arthritis: a disease of T-lymphocyte/macrophage immunoregulation. Lancet. 1981 Oct 17;2(8251):839–842. doi: 10.1016/s0140-6736(81)91107-7. [DOI] [PubMed] [Google Scholar]
  33. Jayson M. I., Dixon A. S. Arthroscopy of the knee in rheumatic diseases. Ann Rheum Dis. 1968 Nov;27(6):503–511. doi: 10.1136/ard.27.6.503. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Kinsella T. D., Baum J., Ziff M. Studies of isolated synovial living cells of rheumatoid and nonrheumatoid synovial membranes. Arthritis Rheum. 1970 Nov-Dec;13(6):734–753. doi: 10.1002/art.1780130603. [DOI] [PubMed] [Google Scholar]
  35. Klareskog L., Forsum U., Kabelitz D., Plöen L., Sundström C., Nilsson K., Wigren A., Wigzell H. Immune functions of human synovial cells. Phenotypic and T cell regulatory properties of macrophage-like cells that express HLA-DR. Arthritis Rheum. 1982 May;25(5):488–501. doi: 10.1002/art.1780250502. [DOI] [PubMed] [Google Scholar]
  36. Kobayashi I., Ziff M. Electron microscopic studies of the cartilage-pannus junction in rheumatoid arthritis. Arthritis Rheum. 1975 Sep-Oct;18(5):475–483. doi: 10.1002/art.1780180507. [DOI] [PubMed] [Google Scholar]
  37. Koch A. E., Kunkel S. L., Burrows J. C., Evanoff H. L., Haines G. K., Pope R. M., Strieter R. M. Synovial tissue macrophage as a source of the chemotactic cytokine IL-8. J Immunol. 1991 Oct 1;147(7):2187–2195. [PubMed] [Google Scholar]
  38. Koch A. E. Review: angiogenesis: implications for rheumatoid arthritis. Arthritis Rheum. 1998 Jun;41(6):951–962. doi: 10.1002/1529-0131(199806)41:6<951::AID-ART2>3.0.CO;2-D. [DOI] [PubMed] [Google Scholar]
  39. Kraan M. C., Haringman J. J., Ahern M. J., Breedveld F. C., Smith M. D., Tak P. P. Quantification of the cell infiltrate in synovial tissue by digital image analysis. Rheumatology (Oxford) 2000 Jan;39(1):43–49. doi: 10.1093/rheumatology/39.1.43. [DOI] [PubMed] [Google Scholar]
  40. Kraan M. C., Versendaal H., Jonker M., Bresnihan B., Post W. J., t Hart B. A., Breedveld F. C., Tak P. P. Asymptomatic synovitis precedes clinically manifest arthritis. Arthritis Rheum. 1998 Aug;41(8):1481–1488. doi: 10.1002/1529-0131(199808)41:8<1481::AID-ART19>3.0.CO;2-O. [DOI] [PubMed] [Google Scholar]
  41. Lindblad S., Hedfors E. Intraarticular variation in synovitis. Local macroscopic and microscopic signs of inflammatory activity are significantly correlated. Arthritis Rheum. 1985 Sep;28(9):977–986. doi: 10.1002/art.1780280904. [DOI] [PubMed] [Google Scholar]
  42. Mulherin D., Fitzgerald O., Bresnihan B. Synovial tissue macrophage populations and articular damage in rheumatoid arthritis. Arthritis Rheum. 1996 Jan;39(1):115–124. doi: 10.1002/art.1780390116. [DOI] [PubMed] [Google Scholar]
  43. Nakajima T., Aono H., Hasunuma T., Yamamoto K., Shirai T., Hirohata K., Nishioka K. Apoptosis and functional Fas antigen in rheumatoid arthritis synoviocytes. Arthritis Rheum. 1995 Apr;38(4):485–491. doi: 10.1002/art.1780380405. [DOI] [PubMed] [Google Scholar]
  44. O'Hara R., Murphy E. P., Whitehead A. S., FitzGerald O., Bresnihan B. Acute-phase serum amyloid A production by rheumatoid arthritis synovial tissue. Arthritis Res. 2000 Feb 24;2(2):142–144. doi: 10.1186/ar78. [DOI] [PMC free article] [PubMed] [Google Scholar]
  45. O'Rourke K. S., Ike R. W. Diagnostic arthroscopy in the arthritis patient. Rheum Dis Clin North Am. 1994 May;20(2):321–342. [PubMed] [Google Scholar]
  46. PARKER R. H., PEARSON C. M. A simplified synovial biopsy needle. Arthritis Rheum. 1963 Apr;6:172–176. doi: 10.1002/art.1780060209. [DOI] [PubMed] [Google Scholar]
  47. POLLEY H. F., BICKEL W. H., DOCKERTY M. B. Experiences with an instrument for punch biopsy of synovial membrane. Proc Staff Meet Mayo Clin. 1951 Jul 18;26(15):273–281. [PubMed] [Google Scholar]
  48. Reece R., Emery P. Needle arthroscopy. Br J Rheumatol. 1995 Dec;34(12):1102–1104. doi: 10.1093/rheumatology/34.12.1102. [DOI] [PubMed] [Google Scholar]
  49. Rooney M., Condell D., Quinlan W., Daly L., Whelan A., Feighery C., Bresnihan B. Analysis of the histologic variation of synovitis in rheumatoid arthritis. Arthritis Rheum. 1988 Aug;31(8):956–963. doi: 10.1002/art.1780310803. [DOI] [PubMed] [Google Scholar]
  50. Rooney M., Whelan A., Feighery C., Bresnihan B. Changes in lymphocyte infiltration of the synovial membrane and the clinical course of rheumatoid arthritis. Arthritis Rheum. 1989 Apr;32(4):361–369. doi: 10.1002/anr.1780320402. [DOI] [PubMed] [Google Scholar]
  51. Rooney M., Whelan A., Feighery C., Bresnihan B. The immunohistologic features of synovitis, disease activity and in vitro IgM rheumatoid factor synthesis by blood mononuclear cells in rheumatoid arthritis. J Rheumatol. 1989 Apr;16(4):459–467. [PubMed] [Google Scholar]
  52. Schumacher H. R., Kitridou R. C. Synovitis of recent onset. A clinicopathologic study during the first month of disease. Arthritis Rheum. 1972 Sep-Oct;15(5):465–485. doi: 10.1002/art.1780150502. [DOI] [PubMed] [Google Scholar]
  53. Shiozawa S., Shiozawa K., Fujita T. Morphologic observations in the early phase of the cartilage-pannus junction. Light and electron microscopic studies of active cellular pannus. Arthritis Rheum. 1983 Apr;26(4):472–478. doi: 10.1002/art.1780260404. [DOI] [PubMed] [Google Scholar]
  54. Smeets T. J., Dayer J. M., Kraan M. C., Versendaal J., Chicheportiche R., Breedveld F. C., Tak P. P. The effects of interferon-beta treatment of synovial inflammation and expression of metalloproteinases in patients with rheumatoid arthritis. Arthritis Rheum. 2000 Feb;43(2):270–274. doi: 10.1002/1529-0131(200002)43:2<270::AID-ANR5>3.0.CO;2-H. [DOI] [PubMed] [Google Scholar]
  55. Smeets T. J., Dolhain RJEM, Miltenburg A. M., de Kuiper R., Breedveld F. C., Tak P. P. Poor expression of T cell-derived cytokines and activation and proliferation markers in early rheumatoid synovial tissue. Clin Immunol Immunopathol. 1998 Jul;88(1):84–90. doi: 10.1006/clin.1998.4525. [DOI] [PubMed] [Google Scholar]
  56. Smeets T. J., Dolhain R. J., Breedveld F. C., Tak P. P. Analysis of the cellular infiltrates and expression of cytokines in synovial tissue from patients with rheumatoid arthritis and reactive arthritis. J Pathol. 1998 Sep;186(1):75–81. doi: 10.1002/(SICI)1096-9896(199809)186:1<75::AID-PATH142>3.0.CO;2-B. [DOI] [PubMed] [Google Scholar]
  57. Soden M., Rooney M., Cullen A., Whelan A., Feighery C., Bresnihan B. Immunohistological features in the synovium obtained from clinically uninvolved knee joints of patients with rheumatoid arthritis. Br J Rheumatol. 1989 Aug;28(4):287–292. doi: 10.1093/rheumatology/28.4.287. [DOI] [PubMed] [Google Scholar]
  58. Tak P. P., Kummer J. A., Hack C. E., Daha M. R., Smeets T. J., Erkelens G. W., Meinders A. E., Kluin P. M., Breedveld F. C. Granzyme-positive cytotoxic cells are specifically increased in early rheumatoid synovial tissue. Arthritis Rheum. 1994 Dec;37(12):1735–1743. doi: 10.1002/art.1780371205. [DOI] [PubMed] [Google Scholar]
  59. Tak P. P., Smeets T. J., Boyle D. L., Kraan M. C., Shi Y., Zhuang S., Zvaifler N. J., Breedveld F. C., Firestein G. S. p53 overexpression in synovial tissue from patients with early and longstanding rheumatoid arthritis compared with patients with reactive arthritis and osteoarthritis. Arthritis Rheum. 1999 May;42(5):948–953. doi: 10.1002/1529-0131(199905)42:5<948::AID-ANR13>3.0.CO;2-L. [DOI] [PubMed] [Google Scholar]
  60. Tak P. P., Smeets T. J., Daha M. R., Kluin P. M., Meijers K. A., Brand R., Meinders A. E., Breedveld F. C. Analysis of the synovial cell infiltrate in early rheumatoid synovial tissue in relation to local disease activity. Arthritis Rheum. 1997 Feb;40(2):217–225. doi: 10.1002/art.1780400206. [DOI] [PubMed] [Google Scholar]
  61. Tak P. P., Taylor P. C., Breedveld F. C., Smeets T. J., Daha M. R., Kluin P. M., Meinders A. E., Maini R. N. Decrease in cellularity and expression of adhesion molecules by anti-tumor necrosis factor alpha monoclonal antibody treatment in patients with rheumatoid arthritis. Arthritis Rheum. 1996 Jul;39(7):1077–1081. doi: 10.1002/art.1780390702. [DOI] [PubMed] [Google Scholar]
  62. Tak P. P., Thurkow E. W., Daha M. R., Kluin P. M., Smeets T. J., Meinders A. E., Breedveld F. C. Expression of adhesion molecules in early rheumatoid synovial tissue. Clin Immunol Immunopathol. 1995 Dec;77(3):236–242. doi: 10.1006/clin.1995.1149. [DOI] [PubMed] [Google Scholar]
  63. Tak P. P., van der Lubbe P. A., Cauli A., Daha M. R., Smeets T. J., Kluin P. M., Meinders A. E., Yanni G., Panayi G. S., Breedveld F. C. Reduction of synovial inflammation after anti-CD4 monoclonal antibody treatment in early rheumatoid arthritis. Arthritis Rheum. 1995 Oct;38(10):1457–1465. doi: 10.1002/art.1780381012. [DOI] [PubMed] [Google Scholar]
  64. Taylor P. C., Peters A. M., Paleolog E., Chapman P. T., Elliott M. J., McCloskey R., Feldmann M., Maini R. N. Reduction of chemokine levels and leukocyte traffic to joints by tumor necrosis factor alpha blockade in patients with rheumatoid arthritis. Arthritis Rheum. 2000 Jan;43(1):38–47. doi: 10.1002/1529-0131(200001)43:1<38::AID-ANR6>3.0.CO;2-L. [DOI] [PubMed] [Google Scholar]
  65. Tetlow L. C., Woolley D. E. Mast cells, cytokines, and metalloproteinases at the rheumatoid lesion: dual immunolocalisation studies. Ann Rheum Dis. 1995 Nov;54(11):896–903. doi: 10.1136/ard.54.11.896. [DOI] [PMC free article] [PubMed] [Google Scholar]
  66. Thomas R., Lipsky P. E. Presentation of self peptides by dendritic cells: possible implications for the pathogenesis of rheumatoid arthritis. Arthritis Rheum. 1996 Feb;39(2):183–190. doi: 10.1002/art.1780390202. [DOI] [PubMed] [Google Scholar]
  67. Trabandt A., Aicher W. K., Gay R. E., Sukhatme V. P., Fassbender H. G., Gay S. Spontaneous expression of immediately-early response genes c-fos and egr-1 in collagenase-producing rheumatoid synovial fibroblasts. Rheumatol Int. 1992;12(2):53–59. doi: 10.1007/BF00300977. [DOI] [PubMed] [Google Scholar]
  68. Veale D. J., Reece R. J., Parsons W., Radjenovic A., O'Connor P. J., Orgles C. S., Berry E., Ridgway J. P., Mason U., Boylston A. W. Intra-articular primatised anti-CD4: efficacy in resistant rheumatoid knees. A study of combined arthroscopy, magnetic resonance imaging, and histology. Ann Rheum Dis. 1999 Jun;58(6):342–349. doi: 10.1136/ard.58.6.342. [DOI] [PMC free article] [PubMed] [Google Scholar]
  69. Wilkinson L. S., Pitsillides A. A., Worrall J. G., Edwards J. C. Light microscopic characterization of the fibroblast-like synovial intimal cell (synoviocyte). Arthritis Rheum. 1992 Oct;35(10):1179–1184. doi: 10.1002/art.1780351010. [DOI] [PubMed] [Google Scholar]
  70. Woolley D. E., Crossley M. J., Evanson J. M. Collagenase at sites of cartilage erosion in the rheumatoid joint. Arthritis Rheum. 1977 Jul-Aug;20(6):1231–1239. doi: 10.1002/art.1780200612. [DOI] [PubMed] [Google Scholar]
  71. Yanni G., Nabil M., Farahat M. R., Poston R. N., Panayi G. S. Intramuscular gold decreases cytokine expression and macrophage numbers in the rheumatoid synovial membrane. Ann Rheum Dis. 1994 May;53(5):315–322. doi: 10.1136/ard.53.5.315. [DOI] [PMC free article] [PubMed] [Google Scholar]
  72. Yates D. B., Scott J. T. Rheumatoid synovitis and joint disease. Relationship between arthroscopic and histological changes. Ann Rheum Dis. 1975 Feb;34(1):1–6. doi: 10.1136/ard.34.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  73. Youssef P. P., Haynes D. R., Triantafillou S., Parker A., Gamble J. R., Roberts-Thomson P. J., Ahern M. J., Smith M. D. Effects of pulse methylprednisolone on inflammatory mediators in peripheral blood, synovial fluid, and synovial membrane in rheumatoid arthritis. Arthritis Rheum. 1997 Aug;40(8):1400–1408. doi: 10.1002/art.1780400807. [DOI] [PubMed] [Google Scholar]
  74. Youssef P. P., Kraan M., Breedveld F., Bresnihan B., Cassidy N., Cunnane G., Emery P., Fitzgerald O., Kane D., Lindblad S. Quantitative microscopic analysis of inflammation in rheumatoid arthritis synovial membrane samples selected at arthroscopy compared with samples obtained blindly by needle biopsy. Arthritis Rheum. 1998 Apr;41(4):663–669. doi: 10.1002/1529-0131(199804)41:4<663::AID-ART13>3.0.CO;2-L. [DOI] [PubMed] [Google Scholar]
  75. Youssef P. P., Smeets T. J., Bresnihan B., Cunnane G., Fitzgerald O., Breedveld F., Tak P. P. Microscopic measurement of cellular infiltration in the rheumatoid arthritis synovial membrane: a comparison of semiquantitative and quantitative analysis. Br J Rheumatol. 1998 Sep;37(9):1003–1007. doi: 10.1093/rheumatology/37.9.1003. [DOI] [PubMed] [Google Scholar]
  76. ZEVELY H. A., FRENCH A. J., MIKKELSEN W. M., DUFF I. F. Synovial specimens obtained by knee joint punch biopsy; histologic study in joint diseases. Am J Med. 1956 Apr;20(4):510–519. doi: 10.1016/0002-9343(56)90135-8. [DOI] [PubMed] [Google Scholar]
  77. Zvaifler N. J., Tsai V., Alsalameh S., von Kempis J., Firestein G. S., Lotz M. Pannocytes: distinctive cells found in rheumatoid arthritis articular cartilage erosions. Am J Pathol. 1997 Mar;150(3):1125–1138. [PMC free article] [PubMed] [Google Scholar]

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