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. 1997 Jun;65(6):2454–2456. doi: 10.1128/iai.65.6.2454-2456.1997

Interleukin-6 production by human monocytes stimulated with Cryptococcus neoformans components.

D Delfino 1, L Cianci 1, E Lupis 1, A Celeste 1, M L Petrelli 1, F Curró 1, V Cusumano 1, G Teti 1
PMCID: PMC175342  PMID: 9169790

Abstract

In order to ascertain if Cryptococcus neoformans components can induce interleukin-6 (IL-6) production, we stimulated human whole blood with purified capsular products. Their potencies in stimulating IL-6 release were mannoproteins > galactoxylomannan = glucuronoxylomannan > alpha(1-3)glucan. IL-6 production was tumor necrosis factor alpha independent and required the presence of monocytes and plasma. Since IL-6 can stimulate replication of the human immunodeficiency virus in monocytic cells, these findings may be clinically relevant.

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Selected References

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