Skip to main content
PMC home page
Infection and Immunity logoLink to Infection and Immunity
. 1997 Jun;65(6):2457–2461. doi: 10.1128/iai.65.6.2457-2461.1997

Infection of BALB/c mice with the filarial nematode Litomosoides sigmodontis: role of CD4+ T cells in controlling larval development.

K M Al-Qaoud 1, A Taubert 1, H Zahner 1, B Fleischer 1, A Hoerauf 1
PMCID: PMC175343  PMID: 9169791

Abstract

Litomosoides sigmodontis is the only filaria which develops from infective larvae into adults in immunocompetent laboratory mice. Depletion of CD4+ T cells from infected BALB/c mice resulted in worm and microfilarial burdens significantly higher than those of infected controls. Th2 cytokines, eosinophilia, and immunoglobulin E, which were strongly induced in infected controls, were diminished in CD4-depleted mice.

Full Text

The Full Text of this article is available as a PDF (153.5 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abraham D., Eberhard M. L., Lange A. M., Yutanawiboonchai W., Perler F. B., Lok J. B. Identification of surrogate rodent hosts for larval Onchocerca lienalis and induction of protective immunity in a model system. J Parasitol. 1992 Jun;78(3):447–453. [PubMed] [Google Scholar]
  2. Abraham D., Lange A. M., Yutanawiboonchai W., Trpis M., Dickerson J. W., Swenson B., Eberhard M. L. Survival and development of larval Onchocerca volvulus in diffusion chambers implanted in primate and rodent hosts. J Parasitol. 1993 Aug;79(4):571–582. [PubMed] [Google Scholar]
  3. Amiri P., Haak-Frendscho M., Robbins K., McKerrow J. H., Stewart T., Jardieu P. Anti-immunoglobulin E treatment decreases worm burden and egg production in Schistosoma mansoni-infected normal and interferon gamma knockout mice. J Exp Med. 1994 Jul 1;180(1):43–51. doi: 10.1084/jem.180.1.43. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bancroft A. J., Grencis R. K., Else K. J., Devaney E. The role of CD4 cells in protective immunity to Brugia pahangi. Parasite Immunol. 1994 Jul;16(7):385–387. doi: 10.1111/j.1365-3024.1994.tb00364.x. [DOI] [PubMed] [Google Scholar]
  5. Bianco A. E., Mustafa M. B., Ham P. J. Fate of developing larvae of Onchocerca lienalis and O. volvulus in micropore chambers implanted into laboratory hosts. J Helminthol. 1989 Sep;63(3):218–226. doi: 10.1017/s0022149x00009019. [DOI] [PubMed] [Google Scholar]
  6. Cobbold S. P., Jayasuriya A., Nash A., Prospero T. D., Waldmann H. Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo. Nature. 1984 Dec 6;312(5994):548–551. doi: 10.1038/312548a0. [DOI] [PubMed] [Google Scholar]
  7. Denham D. A., McGreevy P. B., Suswillo R. R., Rogers R. The resistance to re-infection of cats repeatedly inoculated with infective larvae of Brugia pahangi. Parasitology. 1983 Feb;86(Pt 1):11–18. doi: 10.1017/s0031182000057127. [DOI] [PubMed] [Google Scholar]
  8. Dialynas D. P., Quan Z. S., Wall K. A., Pierres A., Quintáns J., Loken M. R., Pierres M., Fitch F. W. Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule. J Immunol. 1983 Nov;131(5):2445–2451. [PubMed] [Google Scholar]
  9. Eisenbeiss W. F., Apfel H., Meyer T. F. Protective immunity linked with a distinct developmental stage of a filarial parasite. J Immunol. 1994 Jan 15;152(2):735–742. [PubMed] [Google Scholar]
  10. Katona I. M., Urban J. F., Jr, Finkelman F. D. The role of L3T4+ and Lyt-2+ T cells in the IgE response and immunity to Nippostrongylus brasiliensis. J Immunol. 1988 May 1;140(9):3206–3211. [PubMed] [Google Scholar]
  11. Korenaga M., Hitoshi Y., Yamaguchi N., Sato Y., Takatsu K., Tada I. The role of interleukin-5 in protective immunity to Strongyloides venezuelensis infection in mice. Immunology. 1991 Apr;72(4):502–507. [PMC free article] [PubMed] [Google Scholar]
  12. Lange A. M., Yutanawiboonchai W., Scott P., Abraham D. IL-4- and IL-5-dependent protective immunity to Onchocerca volvulus infective larvae in BALB/cBYJ mice. J Immunol. 1994 Jul 1;153(1):205–211. [PubMed] [Google Scholar]
  13. Lawrence R. A., Allen J. E., Osborne J., Maizels R. M. Adult and microfilarial stages of the filarial parasite Brugia malayi stimulate contrasting cytokine and Ig isotype responses in BALB/c mice. J Immunol. 1994 Aug 1;153(3):1216–1224. [PubMed] [Google Scholar]
  14. Lawrence R. A. Lymphatic filariasis: what mice can tell us. Parasitol Today. 1996 Jul;12(7):267–271. doi: 10.1016/0169-4758(96)10025-9. [DOI] [PubMed] [Google Scholar]
  15. Maréchal P., Le Goff L., Petit G., Diagne M., Taylor D. W., Bain O. The fate of the filaria Litomosoides sigmodontis in susceptible and naturally resistant mice. Parasite. 1996 Mar;3(1):25–31. doi: 10.1051/parasite/1996031025. [DOI] [PubMed] [Google Scholar]
  16. Petit G., Diagne M., Maréchal P., Owen D., Taylor D., Bain O. Maturation of the filaria Litomosoides sigmodontis in BALB/c mice; comparative susceptibility of nine other inbred strains. Ann Parasitol Hum Comp. 1992;67(5):144–150. doi: 10.1051/parasite/1992675144. [DOI] [PubMed] [Google Scholar]
  17. Rajan T. V., Nelson F. K., Killeen N., Shultz L. D., Yates J. A., Bailis J. M., Littman D. R., Greiner D. L. CD4+ T-lymphocytes are not required for murine resistance to the human filarial parasite, Brugia malayi. Exp Parasitol. 1994 Jun;78(4):352–360. doi: 10.1006/expr.1994.1038. [DOI] [PubMed] [Google Scholar]
  18. Rajan T. V., Nelson F. K., Shultz L. D., Koller B. H., Greiner D. L. CD8+ T lymphocytes are not required for murine resistance to human filarial parasites. J Parasitol. 1992 Aug;78(4):744–746. [PubMed] [Google Scholar]
  19. Rotman H. L., Yutanawiboonchai W., Brigandi R. A., Leon O., Gleich G. J., Nolan T. J., Schad G. A., Abraham D. Strongyloides stercoralis: eosinophil-dependent immune-mediated killing of third stage larvae in BALB/cByJ mice. Exp Parasitol. 1996 Apr;82(3):267–278. doi: 10.1006/expr.1996.0034. [DOI] [PubMed] [Google Scholar]
  20. Sasaki O., Sugaya H., Ishida K., Yoshimura K. Ablation of eosinophils with anti-IL-5 antibody enhances the survival of intracranial worms of Angiostrongylus cantonensis in the mouse. Parasite Immunol. 1993 Jun;15(6):349–354. doi: 10.1111/j.1365-3024.1993.tb00619.x. [DOI] [PubMed] [Google Scholar]
  21. Taylor M. J., van Es R. P., Shay K., Folkard S. G., Townson S., Bianco A. E. Protective immunity against Onchocerca volvulus and O. lienalis infective larvae in mice. Trop Med Parasitol. 1994 Mar;45(1):17–23. [PubMed] [Google Scholar]
  22. Vickery A. C., Nayar J. K. Brugia pahangi in nude mice: protective immunity to infective larvae is Thy 1.2+ cell dependent and cyclosporin A resistant. J Helminthol. 1987 Mar;61(1):19–27. doi: 10.1017/s0022149x00009664. [DOI] [PubMed] [Google Scholar]
  23. Vickery A. C., Vincent A. L., Sodeman W. A., Jr Effect of immune reconstitution on resistance to Brugia pahangi in congenitally athymic nude mice. J Parasitol. 1983 Jun;69(3):478–485. [PubMed] [Google Scholar]
  24. Zahner H., Wegerhof P. H. Immunity to Litomosoides carinii in Mastomys natalensis. II. Effects of chemotherapeutically abbreviated and postpatent primary infections on challenges with various stages of the parasite. Z Parasitenkd. 1986;72(6):789–804. doi: 10.1007/BF00925099. [DOI] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES