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Figure 1 .
Biochemical markers of tissue destruction, inflammation, and repair. Abbreviations and examples of references referring to the use of these markers: S = synthesis marker; D = degradation marker. PINP = amino-terminal type I procollagen propeptide11; PICP = carboxy-terminal type I procollagen propeptide11; bone-specific ALP = bone-specific alkaline phosphatase12; osteocalcin13; DPYD = deoxypyridinoline14; PYD= pyridinoline15; Glc-Gal-PYD = glucosyl-galactosyl-pyridinoline; NTX= type I collagen N-terminal telopeptide16; CTX = type I collagen C-terminal telopeptide-217; ICTP = type I collagen C-terminal telopeptide-1; TRAP = plasma tartrate resistant acid phosphatase18; BSP = bone sialoprotein19; chondroitin sulphate epitopes 846, 3B3, and 7D420 21; PIICP = carboxy-terminal type II procollagen propeptide20; PIIANP = amino-terminal type IIA procollagen propeptide; YKL-4022; aggrecan core protein fragments23; keratan sulphate epitopes 5D424 AN9P125; collagen type II neoepitopes COL2-3/4m, COL2-1/4N126; CTX-II = type II collagen C-terminal telopeptide; COMP = cartilage oligomeric protein27; MMPs = matrix metalloproteinases28; TIMPs = tissue inhibitors of matrix metalloproteinases28; PIIINP = amino-terminal type III procollagen propeptide.13
Selected References
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