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Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 2001 Jun;60(6):548–549. doi: 10.1136/ard.60.6.548

Stem cell transplantation: limits and hopes

K MACHOLD 1, J SMOLEN 1
PMCID: PMC1753668  PMID: 11350839

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Selected References

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  1. Antman K., Lagakos S., Drazen J. Designing and funding clinical trials of novel therapies. N Engl J Med. 2001 Mar 8;344(10):762–763. doi: 10.1056/NEJM200103083441010. [DOI] [PubMed] [Google Scholar]
  2. Balow J. E., Austin H. A., 3rd, Muenz L. R., Joyce K. M., Antonovych T. T., Klippel J. H., Steinberg A. D., Plotz P. H., Decker J. L. Effect of treatment on the evolution of renal abnormalities in lupus nephritis. N Engl J Med. 1984 Aug 23;311(8):491–495. doi: 10.1056/NEJM198408233110802. [DOI] [PubMed] [Google Scholar]
  3. Bathon J. M., Martin R. W., Fleischmann R. M., Tesser J. R., Schiff M. H., Keystone E. C., Genovese M. C., Wasko M. C., Moreland L. W., Weaver A. L. A comparison of etanercept and methotrexate in patients with early rheumatoid arthritis. N Engl J Med. 2000 Nov 30;343(22):1586–1593. doi: 10.1056/NEJM200011303432201. [DOI] [PubMed] [Google Scholar]
  4. Billinghurst R. C., Dahlberg L., Ionescu M., Reiner A., Bourne R., Rorabeck C., Mitchell P., Hambor J., Diekmann O., Tschesche H. Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage. J Clin Invest. 1997 Apr 1;99(7):1534–1545. doi: 10.1172/JCI119316. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Breban M., Dougados M., Picard F., Zompi S., Marolleau J. P., Bocaccio C., Heshmati F., Mezieres M., Dreyfus F., Bouscary D. Intensified-dose (4 gm/m2) cyclophosphamide and granulocyte colony-stimulating factor administration for hematopoietic stem cell mobilization in refractory rheumatoid arthritis. Arthritis Rheum. 1999 Nov;42(11):2275–2280. doi: 10.1002/1529-0131(199911)42:11<2275::AID-ANR3>3.0.CO;2-6. [DOI] [PubMed] [Google Scholar]
  6. Bryan C., Knight C., Black C. M., Silman A. J. Prediction of five-year survival following presentation with scleroderma: development of a simple model using three disease factors at first visit. Arthritis Rheum. 1999 Dec;42(12):2660–2665. doi: 10.1002/1529-0131(199912)42:12<2660::AID-ANR23>3.0.CO;2-N. [DOI] [PubMed] [Google Scholar]
  7. Burt R. K., Georganas C., Schroeder J., Traynor A., Stefka J., Schuening F., Graziano F., Mineishi S., Brush M., Fishman M. Autologous hematopoietic stem cell transplantation in refractory rheumatoid arthritis: sustained response in two of four patients. Arthritis Rheum. 1999 Nov;42(11):2281–2285. doi: 10.1002/1529-0131(199911)42:11<2281::AID-ANR4>3.0.CO;2-E. [DOI] [PubMed] [Google Scholar]
  8. Clements P. J., Furst D. E., Wong W. K., Mayes M., White B., Wigley F., Weisman M. H., Barr W., Moreland L. W., Medsger T. A., Jr High-dose versus low-dose D-penicillamine in early diffuse systemic sclerosis: analysis of a two-year, double-blind, randomized, controlled clinical trial. Arthritis Rheum. 1999 Jun;42(6):1194–1203. doi: 10.1002/1529-0131(199906)42:6<1194::AID-ANR16>3.0.CO;2-7. [DOI] [PubMed] [Google Scholar]
  9. Eedy D. J., Burrows D., Bridges J. M., Jones F. G. Clearance of severe psoriasis after allogenic bone marrow transplantation. BMJ. 1990 Apr 7;300(6729):908–908. doi: 10.1136/bmj.300.6729.908. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Evans P. C., Lambert N., Maloney S., Furst D. E., Moore J. M., Nelson J. L. Long-term fetal microchimerism in peripheral blood mononuclear cell subsets in healthy women and women with scleroderma. Blood. 1999 Mar 15;93(6):2033–2037. [PubMed] [Google Scholar]
  11. Gisslinger H., Burghuber O. C., Stacher G., Schwarz W., Punzengruber C., Graninger W., Luger T. A., Wolff K., Smolen J. S. Efficacy of cyclosporin A in systemic sclerosis. Clin Exp Rheumatol. 1991 Jul-Aug;9(4):383–390. [PubMed] [Google Scholar]
  12. Jacobs P., Vincent M. D., Martell R. W. Prolonged remission of severe refractory rheumatoid arthritis following allogeneic bone marrow transplantation for drug-induced aplastic anaemia. Bone Marrow Transplant. 1986 Dec;1(2):237–239. [PubMed] [Google Scholar]
  13. Klings E. S., Hill N. S., Ieong M. H., Simms R. W., Korn J. H., Farber H. W. Systemic sclerosis-associated pulmonary hypertension: short- and long-term effects of epoprostenol (prostacyclin). Arthritis Rheum. 1999 Dec;42(12):2638–2645. doi: 10.1002/1529-0131(199912)42:12<2638::AID-ANR20>3.0.CO;2-X. [DOI] [PubMed] [Google Scholar]
  14. Lipsky P. E., van der Heijde D. M., St Clair E. W., Furst D. E., Breedveld F. C., Kalden J. R., Smolen J. S., Weisman M., Emery P., Feldmann M. Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group. N Engl J Med. 2000 Nov 30;343(22):1594–1602. doi: 10.1056/NEJM200011303432202. [DOI] [PubMed] [Google Scholar]
  15. Lueking A., Horn M., Eickhoff H., Büssow K., Lehrach H., Walter G. Protein microarrays for gene expression and antibody screening. Anal Biochem. 1999 May 15;270(1):103–111. doi: 10.1006/abio.1999.4063. [DOI] [PubMed] [Google Scholar]
  16. Manicourt D. H., Fujimoto N., Obata K., Thonar E. J. Serum levels of collagenase, stromelysin-1, and TIMP-1. Age- and sex-related differences in normal subjects and relationship to the extent of joint involvement and serum levels of antigenic keratan sulfate in patients with osteoarthritis. Arthritis Rheum. 1994 Dec;37(12):1774–1783. doi: 10.1002/art.1780371211. [DOI] [PubMed] [Google Scholar]
  17. Marmont A. M., Van Bekkum D. W. Stem cell transplantation for severe autoimmune diseases: new proposals but still unanswered questions. Bone Marrow Transplant. 1995 Oct;16(4):497–498. [PubMed] [Google Scholar]
  18. Mease P. J., Goffe B. S., Metz J., VanderStoep A., Finck B., Burge D. J. Etanercept in the treatment of psoriatic arthritis and psoriasis: a randomised trial. Lancet. 2000 Jul 29;356(9227):385–390. doi: 10.1016/S0140-6736(00)02530-7. [DOI] [PubMed] [Google Scholar]
  19. Poole A. R., Webber C., Reiner A., Roughley P. J. Studies of a monoclonal antibody to skeletal keratan sulphate. Importance of antibody valency. Biochem J. 1989 Jun 15;260(3):849–856. doi: 10.1042/bj2600849. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Roubenoff R., Jones R. J., Karp J. E., Stevens M. B. Remission of rheumatoid arthritis with the successful treatment of acute myelogenous leukemia with cytosine arabinoside, daunorubicin, and m-AMSA. Arthritis Rheum. 1987 Oct;30(10):1187–1190. doi: 10.1002/art.1780301017. [DOI] [PubMed] [Google Scholar]
  21. Salisbury C., Sharif M. Relations between synovial fluid and serum concentrations of osteocalcin and other markers of joint tissue turnover in the knee joint compared with peripheral blood. Ann Rheum Dis. 1997 Sep;56(9):558–561. doi: 10.1136/ard.56.9.558. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Saxne T., Glennås A., Kvien T. K., Melby K., Heinegård D. Release of cartilage macromolecules into the synovial fluid in patients with acute and prolonged phases of reactive arthritis. Arthritis Rheum. 1993 Jan;36(1):20–25. doi: 10.1002/art.1780360105. [DOI] [PubMed] [Google Scholar]
  23. Smolen J. S., Kalden J. R., Scott D. L., Rozman B., Kvien T. K., Larsen A., Loew-Friedrich I., Oed C., Rosenburg R. Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis: a double-blind, randomised, multicentre trial. European Leflunomide Study Group. Lancet. 1999 Jan 23;353(9149):259–266. doi: 10.1016/s0140-6736(98)09403-3. [DOI] [PubMed] [Google Scholar]
  24. Smolen J. S., Strand V., Cardiel M., Edworthy S., Furst D., Gladman D., Gordon C., Isenberg D. A., Klippel J. H., Petri M. Randomized clinical trials and longitudinal observational studies in systemic lupus erythematosus: consensus on a preliminary core set of outcome domains. J Rheumatol. 1999 Feb;26(2):504–507. [PubMed] [Google Scholar]
  25. Snowden J. A., Atkinson K., Kearney P., Brooks P., Biggs J. C. Allogeneic bone marrow transplantation from a donor with severe active rheumatoid arthritis not resulting in adoptive transfer of disease to recipient. Bone Marrow Transplant. 1997 Jul;20(1):71–73. doi: 10.1038/sj.bmt.1700835. [DOI] [PubMed] [Google Scholar]
  26. Traynor A. E., Schroeder J., Rosa R. M., Cheng D., Stefka J., Mujais S., Baker S., Burt R. K. Treatment of severe systemic lupus erythematosus with high-dose chemotherapy and haemopoietic stem-cell transplantation: a phase I study. Lancet. 2000 Aug 26;356(9231):701–707. doi: 10.1016/S0140-6736(00)02627-1. [DOI] [PubMed] [Google Scholar]
  27. Tyndall A., Gratwohl A. Blood and marrow stem cell transplants in autoimmune disease. A consensus report written on behalf of the European League Against Rheumatism (EULAR) and the European Group for Blood and Marrow Transplantation (EBMT). Br J Rheumatol. 1997 Mar;36(3):390–392. doi: 10.1093/rheumatology/36.3.390. [DOI] [PubMed] [Google Scholar]
  28. Van den Bosch F., Kruithof E., Baeten D., De Keyser F., Mielants H., Veys E. M. Effects of a loading dose regimen of three infusions of chimeric monoclonal antibody to tumour necrosis factor alpha (infliximab) in spondyloarthropathy: an open pilot study. Ann Rheum Dis. 2000 Jun;59(6):428–433. doi: 10.1136/ard.59.6.428. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Yin J. A., Jowitt S. N. Resolution of immune-mediated diseases following allogeneic bone marrow transplantation for leukaemia. Bone Marrow Transplant. 1992 Jan;9(1):31–33. [PubMed] [Google Scholar]
  30. van Hal N. L., Vorst O., van Houwelingen A. M., Kok E. J., Peijnenburg A., Aharoni A., van Tunen A. J., Keijer J. The application of DNA microarrays in gene expression analysis. J Biotechnol. 2000 Mar 31;78(3):271–280. doi: 10.1016/s0168-1656(00)00204-2. [DOI] [PubMed] [Google Scholar]
  31. van Riel P. L., Haagsma C. J., Furst D. E. Pharmacotherapeutic combination strategies with disease-modifying antirheumatic drugs in established rheumatoid arthritis. Baillieres Best Pract Res Clin Rheumatol. 1999 Dec;13(4):689–700. doi: 10.1053/berh.1999.0054. [DOI] [PubMed] [Google Scholar]

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