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. 2002 Nov;61(11):957–959. doi: 10.1136/ard.61.11.957

MMPs and rheumatoid synovial fibroblasts: Siamese twins in joint destruction?

U Muller-Ladner, S Gay
PMCID: PMC1753947  PMID: 12379515

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Selected References

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  1. Ahrens D., Koch A. E., Pope R. M., Stein-Picarella M., Niedbala M. J. Expression of matrix metalloproteinase 9 (96-kd gelatinase B) in human rheumatoid arthritis. Arthritis Rheum. 1996 Sep;39(9):1576–1587. doi: 10.1002/art.1780390919. [DOI] [PubMed] [Google Scholar]
  2. Borghaei R. C., Sullivan C., Mochan E. Identification of a cytokine-induced repressor of interleukin-1 stimulated expression of stromelysin 1 (MMP-3). J Biol Chem. 1999 Jan 22;274(4):2126–2131. doi: 10.1074/jbc.274.4.2126. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Brown P. D. Ongoing trials with matrix metalloproteinase inhibitors. Expert Opin Investig Drugs. 2000 Sep;9(9):2167–2177. doi: 10.1517/13543784.9.9.2167. [DOI] [PubMed] [Google Scholar]
  4. Cunnane G., FitzGerald O., Hummel K. M., Gay R. E., Gay S., Bresnihan B. Collagenase, cathepsin B and cathepsin L gene expression in the synovial membrane of patients with early inflammatory arthritis. Rheumatology (Oxford) 1999 Jan;38(1):34–42. doi: 10.1093/rheumatology/38.1.34. [DOI] [PubMed] [Google Scholar]
  5. Ermis A., Müller B., Hopf T., Hopf C., Remberger K., Jüsten H. P., Welter C., Hanselmann R. Invasion of human cartilage by cultured multicellular spheroids of rheumatoid synovial cells--a novel in vitro model system for rheumatoid arthritis. J Rheumatol. 1998 Feb;25(2):208–213. [PubMed] [Google Scholar]
  6. Firestein Gary S., Pisetsky David S. DNA microarrays: boundless technology or bound by technology? Guidelines for studies using microarray technology. Arthritis Rheum. 2002 Apr;46(4):859–861. doi: 10.1002/art.10236. [DOI] [PubMed] [Google Scholar]
  7. Firestein Gary S., Zvaifler Nathan J. How important are T cells in chronic rheumatoid synovitis?: II. T cell-independent mechanisms from beginning to end. Arthritis Rheum. 2002 Feb;46(2):298–308. doi: 10.1002/art.502. [DOI] [PubMed] [Google Scholar]
  8. Gruber B. L., Sorbi D., French D. L., Marchese M. J., Nuovo G. J., Kew R. R., Arbeit L. A. Markedly elevated serum MMP-9 (gelatinase B) levels in rheumatoid arthritis: a potentially useful laboratory marker. Clin Immunol Immunopathol. 1996 Feb;78(2):161–171. doi: 10.1006/clin.1996.0025. [DOI] [PubMed] [Google Scholar]
  9. Hanemaaijer R., Sorsa T., Konttinen Y. T., Ding Y., Sutinen M., Visser H., van Hinsbergh V. W., Helaakoski T., Kainulainen T., Rönkä H. Matrix metalloproteinase-8 is expressed in rheumatoid synovial fibroblasts and endothelial cells. Regulation by tumor necrosis factor-alpha and doxycycline. J Biol Chem. 1997 Dec 12;272(50):31504–31509. doi: 10.1074/jbc.272.50.31504. [DOI] [PubMed] [Google Scholar]
  10. Hou Wu-Shiun, Li Weijie, Keyszer Gernot, Weber Ekkehard, Levy Roger, Klein Michael J., Gravallese Ellen M., Goldring Steven R., Brömme Dieter. Comparison of cathepsins K and S expression within the rheumatoid and osteoarthritic synovium. Arthritis Rheum. 2002 Mar;46(3):663–674. doi: 10.1002/art.10114. [DOI] [PubMed] [Google Scholar]
  11. Hummel K. M., Petrow P. K., Franz J. K., Müller-Ladner U., Aicher W. K., Gay R. E., Brömme D., Gay S. Cysteine proteinase cathepsin K mRNA is expressed in synovium of patients with rheumatoid arthritis and is detected at sites of synovial bone destruction. J Rheumatol. 1998 Oct;25(10):1887–1894. [PubMed] [Google Scholar]
  12. Konttinen Y. T., Ceponis A., Takagi M., Ainola M., Sorsa T., Sutinen M., Salo T., Ma J., Santavirta S., Seiki M. New collagenolytic enzymes/cascade identified at the pannus-hard tissue junction in rheumatoid arthritis: destruction from above. Matrix Biol. 1998 Dec;17(8-9):585–601. doi: 10.1016/s0945-053x(98)90110-x. [DOI] [PubMed] [Google Scholar]
  13. Konttinen Y. T., Salo T., Hanemaaijer R., Valleala H., Sorsa T., Sutinen M., Ceponis A., Xu J. W., Santavirta S., Teronen O. Collagenase-3 (MMP-13) and its activators in rheumatoid arthritis: localization in the pannus-hard tissue junction and inhibition by alendronate. Matrix Biol. 1999 Aug;18(4):401–412. doi: 10.1016/s0945-053x(99)00030-x. [DOI] [PubMed] [Google Scholar]
  14. Lewis E. J., Bishop J., Bottomley K. M., Bradshaw D., Brewster M., Broadhurst M. J., Brown P. A., Budd J. M., Elliott L., Greenham A. K. Ro 32-3555, an orally active collagenase inhibitor, prevents cartilage breakdown in vitro and in vivo. Br J Pharmacol. 1997 Jun;121(3):540–546. doi: 10.1038/sj.bjp.0701150. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Maeda S., Sawai T., Uzuki M., Takahashi Y., Omoto H., Seki M., Sakurai M. Determination of interstitial collagenase (MMP-1) in patients with rheumatoid arthritis. Ann Rheum Dis. 1995 Dec;54(12):970–975. doi: 10.1136/ard.54.12.970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Mudgett J. S., Hutchinson N. I., Chartrain N. A., Forsyth A. J., McDonnell J., Singer I. I., Bayne E. K., Flanagan J., Kawka D., Shen C. F. Susceptibility of stromelysin 1-deficient mice to collagen-induced arthritis and cartilage destruction. Arthritis Rheum. 1998 Jan;41(1):110–121. doi: 10.1002/1529-0131(199801)41:1<110::AID-ART14>3.0.CO;2-G. [DOI] [PubMed] [Google Scholar]
  17. Müller-Ladner U., Kriegsmann J., Franklin B. N., Matsumoto S., Geiler T., Gay R. E., Gay S. Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice. Am J Pathol. 1996 Nov;149(5):1607–1615. [PMC free article] [PubMed] [Google Scholar]
  18. Neidhart M., Gay R. E., Gay S. Anti-interleukin-1 and anti-CD44 interventions producing significant inhibition of cartilage destruction in an in vitro model of cartilage invasion by rheumatoid arthritis synovial fibroblasts. Arthritis Rheum. 2000 Aug;43(8):1719–1728. doi: 10.1002/1529-0131(200008)43:8<1719::AID-ANR7>3.0.CO;2-4. [DOI] [PubMed] [Google Scholar]
  19. Neumann E., Kullmann F., Judex M., Jüsten H. P., Wessinghage D., Gay S., Schölmerich J., Müller-Ladner U. Identification of differentially expressed genes in rheumatoid arthritis by a combination of complementary DNA array and RNA arbitrarily primed-polymerase chain reaction. Arthritis Rheum. 2002 Jan;46(1):52–63. doi: 10.1002/1529-0131(200201)46:1<52::AID-ART10048>3.0.CO;2-1. [DOI] [PubMed] [Google Scholar]
  20. Pap T., Shigeyama Y., Kuchen S., Fernihough J. K., Simmen B., Gay R. E., Billingham M., Gay S. Differential expression pattern of membrane-type matrix metalloproteinases in rheumatoid arthritis. Arthritis Rheum. 2000 Jun;43(6):1226–1232. doi: 10.1002/1529-0131(200006)43:6<1226::AID-ANR5>3.0.CO;2-4. [DOI] [PubMed] [Google Scholar]
  21. Seki T., Selby J., Häupl T., Winchester R. Use of differential subtraction method to identify genes that characterize the phenotype of cultured rheumatoid arthritis synoviocytes. Arthritis Rheum. 1998 Aug;41(8):1356–1364. doi: 10.1002/1529-0131(199808)41:8<1356::AID-ART4>3.0.CO;2-X. [DOI] [PubMed] [Google Scholar]
  22. Tolboom T. C. A., Pieterman E., van der Laan W. H., Toes R. E. M., Huidekoper A. L., Nelissen R. G. H. H., Breedveld F. C., Huizinga T. W. J. Invasive properties of fibroblast-like synoviocytes: correlation with growth characteristics and expression of MMP-1, MMP-3, and MMP-10. Ann Rheum Dis. 2002 Nov;61(11):975–980. doi: 10.1136/ard.61.11.975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Tomita Tetsuya, Nakase Takanobu, Kaneko Motoharu, Shi Kenrin, Takahi Koichiro, Ochi Takahiro, Yoshikawa Hideki. Expression of extracellular matrix metalloproteinase inducer and enhancement of the production of matrix metalloproteinases in rheumatoid arthritis. Arthritis Rheum. 2002 Feb;46(2):373–378. doi: 10.1002/art.10050. [DOI] [PubMed] [Google Scholar]
  24. Vincenti M. P., Coon C. I., Brinckerhoff C. E. Nuclear factor kappaB/p50 activates an element in the distal matrix metalloproteinase 1 promoter in interleukin-1beta-stimulated synovial fibroblasts. Arthritis Rheum. 1998 Nov;41(11):1987–1994. doi: 10.1002/1529-0131(199811)41:11<1987::AID-ART14>3.0.CO;2-8. [DOI] [PubMed] [Google Scholar]
  25. Wernicke Dirk, Schulze-Westhoff Claudia, Bräuer Rolf, Petrow Peter, Zacher Josef, Gay Steffen, Gromnica-Ihle Erika. Stimulation of collagenase 3 expression in synovial fibroblasts of patients with rheumatoid arthritis by contact with a three-dimensional collagen matrix or with normal cartilage when coimplanted in NOD/SCID mice. Arthritis Rheum. 2002 Jan;46(1):64–74. doi: 10.1002/1529-0131(200201)46:1<64::AID-ART10069>3.0.CO;2-Q. [DOI] [PubMed] [Google Scholar]
  26. Westhoff C. S., Freudiger D., Petrow P., Seyfert C., Zacher J., Kriegsmann J., Pap T., Gay S., Stiehl P., Gromnica-Ihle E. Characterization of collagenase 3 (matrix metalloproteinase 13) messenger RNA expression in the synovial membrane and synovial fibroblasts of patients with rheumatoid arthritis. Arthritis Rheum. 1999 Jul;42(7):1517–1527. doi: 10.1002/1529-0131(199907)42:7<1517::AID-ANR27>3.0.CO;2-G. [DOI] [PubMed] [Google Scholar]

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