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. 1997 Jul;65(7):2883–2889. doi: 10.1128/iai.65.7.2883-2889.1997

Mycobacterium tuberculosis Des protein: an immunodominant target for the humoral response of tuberculous patients.

M Jackson 1, D Portnoï 1, D Catheline 1, L Dumail 1, J Rauzier 1, P Legrand 1, B Gicquel 1
PMCID: PMC175405  PMID: 9199463

Abstract

The phoA gene fusion methodology permitted the identification of a new Mycobacterium tuberculosis exported protein, Des. This protein has significant sequence similarities to plant acyl-acyl carrier protein desaturases, which are enzymes involved in general fatty acid biosynthesis as well as in mycolic acid biosynthesis in mycobacteria. As shown by Western blot and enzyme-linked immunosorbent assay experiments, the Des protein is a major B-cell antigen that was recognized by all the tuberculous M. tuberculosis- and M. bovis-infected human patients tested.

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Selected References

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