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. 1997 Jul;65(7):2987–2991. doi: 10.1128/iai.65.7.2987-2991.1997

Lymphocyte proliferative responses of goats vaccinated with Brucella melitensis 16M or a delta purE201 strain.

S C Olsen 1, N F Cheville 1, M G Stevens 1, H H Houng 1, E S Drazek 1, T L Hadfield 1, R L Warren 1, D L Hoover 1
PMCID: PMC175420  PMID: 9199478

Abstract

The response to a Brucella melitensis purEK deletion mutant, delta purE201 (referred to as strain 201), was compared with the response to its parental strain, 16M, in juvenile goats. Proliferative responses to gamma-irradiated bacteria were detected earlier in strain 201-infected goats. Lymphocytes from strain 16M- or 201-infected goats proliferated in response to one-dimensional polyacrylamide gel electrophoresis-separated proteins of similar mass isolated from strain 16M or Brucella abortus RB51. Data from this study suggest that some antigens stimulating cell-mediated responses are conserved among Brucella species, as 201- and 16M-infected goats recognized similar proteins expressed by RB51 and 16M.

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Selected References

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