Abstract
Method: A total of 155 patients with RA and 110 healthy subjects were studied. DNA was extracted from peripheral leucocytes and TGFß1 codon 10 T869C polymorphism was determined by polymerase chain reaction restriction fragment polymorphism.
Results: A significantly higher proportion of patients with RA with the T allele (CT type or TT type) was found compared with the CC type (p=0.039).
Conclusion: The T allele, previously reported to be linked with production of TGFß1, may be associated with an increased risk of RA.
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