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. 2003 Jan;62(1):1–3. doi: 10.1136/ard.62.1.1-a

Defective waste disposal: does it induce autoantibodies in SLE?

P Charles
PMCID: PMC1754276  PMID: 12480659

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Figure 1 .

Figure 1

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The process of apoptosis and the potential points in that process at which deficiency or mutations may lead to the induction of autoimmune diseases. ? indicates no autoimmune induction currently identified with this mechanism; ALPS, autoimmune lymphoproliferative syndrome; (h), human; (m), marine.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Amoura Z., Piette J. C., Chabre H., Cacoub P., Papo T., Wechsler B., Bach J. F., Koutouzov S. Circulating plasma levels of nucleosomes in patients with systemic lupus erythematosus: correlation with serum antinucleosome antibody titers and absence of clear association with disease activity. Arthritis Rheum. 1997 Dec;40(12):2217–2225. doi: 10.1002/art.1780401217. [DOI] [PubMed] [Google Scholar]
  2. Casciola-Rosen L. A., Anhalt G., Rosen A. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J Exp Med. 1994 Apr 1;179(4):1317–1330. doi: 10.1084/jem.179.4.1317. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Casciola-Rosen L., Andrade F., Ulanet D., Wong W. B., Rosen A. Cleavage by granzyme B is strongly predictive of autoantigen status: implications for initiation of autoimmunity. J Exp Med. 1999 Sep 20;190(6):815–826. doi: 10.1084/jem.190.6.815. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Davies K. A., Peters A. M., Beynon H. L., Walport M. J. Immune complex processing in patients with systemic lupus erythematosus. In vivo imaging and clearance studies. J Clin Invest. 1992 Nov;90(5):2075–2083. doi: 10.1172/JCI116090. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Davies Kevin A., Robson Michael G., Peters A. Michael, Norsworthy Peter, Nash Julian T., Walport Mark J. Defective Fc-dependent processing of immune complexes in patients with systemic lupus erythematosus. Arthritis Rheum. 2002 Apr;46(4):1028–1038. doi: 10.1002/art.10189. [DOI] [PubMed] [Google Scholar]
  6. Du Clos T. W., Zlock L. T., Hicks P. S., Mold C. Decreased autoantibody levels and enhanced survival of (NZB x NZW) F1 mice treated with C-reactive protein. Clin Immunol Immunopathol. 1994 Jan;70(1):22–27. doi: 10.1006/clin.1994.1005. [DOI] [PubMed] [Google Scholar]
  7. Greidinger E. L., Casciola-Rosen L., Morris S. M., Hoffman R. W., Rosen A. Autoantibody recognition of distinctly modified forms of the U1-70-kd antigen is associated with different clinical disease manifestations. Arthritis Rheum. 2000 Apr;43(4):881–888. doi: 10.1002/1529-0131(200004)43:4<881::AID-ANR20>3.0.CO;2-G. [DOI] [PubMed] [Google Scholar]
  8. Huggins M. L., Todd I., Cavers M. A., Pavuluri S. R., Tighe P. J., Powell R. J. Antibodies from systemic lupus erythematosus (SLE) sera define differential release of autoantigens from cell lines undergoing apoptosis. Clin Exp Immunol. 1999 Nov;118(2):322–328. doi: 10.1046/j.1365-2249.1999.01063.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Licht R., van Bruggen M. C., Oppers-Walgreen B., Rijke T. P., Berden J. H. Plasma levels of nucleosomes and nucleosome-autoantibody complexes in murine lupus: effects of disease progression and lipopolyssacharide administration. Arthritis Rheum. 2001 Jun;44(6):1320–1330. doi: 10.1002/1529-0131(200106)44:6<1320::AID-ART224>3.0.CO;2-X. [DOI] [PubMed] [Google Scholar]
  10. Martin D. A., Zheng L., Siegel R. M., Huang B., Fisher G. H., Wang J., Jackson C. E., Puck J. M., Dale J., Straus S. E. Defective CD95/APO-1/Fas signal complex formation in the human autoimmune lymphoproliferative syndrome, type Ia. Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4552–4557. doi: 10.1073/pnas.96.8.4552. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Mitchell Daniel A., Pickering Matthew C., Warren Joanna, Fossati-Jimack Liliane, Cortes-Hernandez Josefina, Cook H. Terence, Botto Marina, Walport Mark J. C1q deficiency and autoimmunity: the effects of genetic background on disease expression. J Immunol. 2002 Mar 1;168(5):2538–2543. doi: 10.4049/jimmunol.168.5.2538. [DOI] [PubMed] [Google Scholar]
  12. Napirei M., Karsunky H., Zevnik B., Stephan H., Mannherz H. G., Möröy T. Features of systemic lupus erythematosus in Dnase1-deficient mice. Nat Genet. 2000 Jun;25(2):177–181. doi: 10.1038/76032. [DOI] [PubMed] [Google Scholar]
  13. Navratil J. S., Ahearn J. M. Apoptosis, clearance mechanisms, and the development of systemic lupus erythematosus. Curr Rheumatol Rep. 2001 Jun;3(3):191–198. doi: 10.1007/s11926-001-0018-1. [DOI] [PubMed] [Google Scholar]
  14. Rosen A., Casciola-Rosen L. Autoantigens as substrates for apoptotic proteases: implications for the pathogenesis of systemic autoimmune disease. Cell Death Differ. 1999 Jan;6(1):6–12. doi: 10.1038/sj.cdd.4400460. [DOI] [PubMed] [Google Scholar]
  15. Wang J., Zheng L., Lobito A., Chan F. K., Dale J., Sneller M., Yao X., Puck J. M., Straus S. E., Lenardo M. J. Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II. Cell. 1999 Jul 9;98(1):47–58. doi: 10.1016/S0092-8674(00)80605-4. [DOI] [PubMed] [Google Scholar]
  16. de la Fuente H., Richaud-Patin Y., Jakez-Ocampo J., González-Amaro R., Llorente L. Innate immune mechanisms in the pathogenesis of systemic lupus erythematosus (SLE). Immunol Lett. 2001 Jul 2;77(3):175–180. doi: 10.1016/s0165-2478(01)00220-6. [DOI] [PubMed] [Google Scholar]
  17. van Nieuwenhuijze A. E. M., van Lopik T., Smeenk R. J. T., Aarden L. A. Time between onset of apoptosis and release of nucleosomes from apoptotic cells: putative implications for systemic lupus erythematosus. Ann Rheum Dis. 2003 Jan;62(1):10–14. doi: 10.1136/ard.62.1.10. [DOI] [PMC free article] [PubMed] [Google Scholar]

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