Skip to main content
NCBI home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 2003 Aug;62(8):697–699. doi: 10.1136/ard.62.8.697

Risk of cancer in patients with scleroderma

J Pearson 1, A Silman 1
PMCID: PMC1754622  PMID: 12860720

Full Text

The Full Text of this article is available as a PDF (86.1 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abu-Shakra M., Guillemin F., Lee P. Cancer in systemic sclerosis. Arthritis Rheum. 1993 Apr;36(4):460–464. doi: 10.1002/art.1780360405. [DOI] [PubMed] [Google Scholar]
  2. Abu-Shakra M., Lee P. Exaggerated fibrosis in patients with systemic sclerosis (scleroderma) following radiation therapy. J Rheumatol. 1993 Sep;20(9):1601–1603. [PubMed] [Google Scholar]
  3. Bielefeld P., Meyer P., Caillot D., Dalac S., Camus P., Tavernier C., Couillaut G., Chalopin J. M., Besancenot J. F. Sclérodermie systémique et cancers: 21 observations et revue de la littérature. Rev Med Interne. 1996;17(10):810–813. doi: 10.1016/0248-8663(96)82683-x. [DOI] [PubMed] [Google Scholar]
  4. Black K. A., Zilko P. J., Dawkins R. L., Armstrong B. K., Mastaglia G. L. Cancer in connective tissue disease. Arthritis Rheum. 1982 Sep;25(9):1130–1133. doi: 10.1002/art.1780250916. [DOI] [PubMed] [Google Scholar]
  5. Bouros Demosthenes, Hatzakis Kostas, Labrakis Haris, Zeibecoglou Kyriaki. Association of malignancy with diseases causing interstitial pulmonary changes. Chest. 2002 Apr;121(4):1278–1289. doi: 10.1378/chest.121.4.1278. [DOI] [PubMed] [Google Scholar]
  6. Comer M., Harvey A. R. Remission of scleroderma during chemotherapy for lymphoma. Ann Rheum Dis. 1992 Aug;51(8):998–1000. doi: 10.1136/ard.51.8.998. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Davis D. A., Cohen P. R., McNeese M. D., Duvic M. Localized scleroderma in breast cancer patients treated with supervoltage external beam radiation: radiation port scleroderma. J Am Acad Dermatol. 1996 Dec;35(6):923–927. doi: 10.1016/s0190-9622(96)90116-4. [DOI] [PubMed] [Google Scholar]
  8. De Angelis R., Bugatti L., Cerioni A., Del Medico P., Filosa G. Diffuse scleroderma occurring after the use of paclitaxel for ovarian cancer. Clin Rheumatol. 2003 Feb;22(1):49–52. doi: 10.1007/s10067-002-0635-8. [DOI] [PubMed] [Google Scholar]
  9. Diot E., Lesire V., Guilmot J. L., Metzger M. D., Pilore R., Rogier S., Stadler M., Diot P., Lemarie E., Lasfargues G. Systemic sclerosis and occupational risk factors: a case-control study. Occup Environ Med. 2002 Aug;59(8):545–549. doi: 10.1136/oem.59.8.545. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Duncan S. C., Winkelmann R. K. Cancer and scleroderma. Arch Dermatol. 1979 Aug;115(8):950–955. [PubMed] [Google Scholar]
  11. Emir S., Kutluk T., Topaloğlu R., Bakkaloğlu A., Büyükpamukçu M. Scleroderma in a child after chemotherapy for cancer. Clin Exp Rheumatol. 2001 Mar-Apr;19(2):221–223. [PubMed] [Google Scholar]
  12. Finkelstein M. M. Silica, silicosis, and lung cancer: a risk assessment. Am J Ind Med. 2000 Jul;38(1):8–18. doi: 10.1002/1097-0274(200007)38:1<8::aid-ajim2>3.0.co;2-#. [DOI] [PubMed] [Google Scholar]
  13. Forbes A. M., Woodrow J. C., Verbov J. L., Graham R. M. Carcinoma of breast and scleroderma: four further cases and a literature review. Br J Rheumatol. 1989 Feb;28(1):65–69. doi: 10.1093/rheumatology/28.1.65. [DOI] [PubMed] [Google Scholar]
  14. Hassett G., Harnett P., Manolios N. Scleroderma in association with the use of docetaxel (taxotere) for breast cancer. Clin Exp Rheumatol. 2001 Mar-Apr;19(2):197–200. [PubMed] [Google Scholar]
  15. Higuchi M., Horiuchi T., Ishibashi N., Yoshizawa S., Niho Y., Nagasawa K. Anticentromere antibody as a risk factor for cancer in patients with systemic sclerosis. Clin Rheumatol. 2000;19(2):123–126. doi: 10.1007/s100670050029. [DOI] [PubMed] [Google Scholar]
  16. Hill C. L., Nguyen A-M, Roder D., Roberts-Thomson P. Risk of cancer in patients with scleroderma: a population based cohort study. Ann Rheum Dis. 2003 Aug;62(8):728–731. doi: 10.1136/ard.62.8.728. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Hochberg M. C., Perlmutter D. L., Medsger T. A., Jr, Nguyen K., Steen V., Weisman M. H., White B., Wigley F. M. Lack of association between augmentation mammoplasty and systemic sclerosis (scleroderma). Arthritis Rheum. 1996 Jul;39(7):1125–1131. doi: 10.1002/art.1780390708. [DOI] [PubMed] [Google Scholar]
  18. Janowsky E. C., Kupper L. L., Hulka B. S. Meta-analyses of the relation between silicone breast implants and the risk of connective-tissue diseases. N Engl J Med. 2000 Mar 16;342(11):781–790. doi: 10.1056/NEJM200003163421105. [DOI] [PubMed] [Google Scholar]
  19. Karim M., Vaux E., Davies D. R., Mason P. D. Renal failure due to scleroderma with thrombotic microangiopathy developing in a woman treated with carboplatin for ovarian cancer. Clin Nephrol. 2002 Nov;58(5):384–388. doi: 10.5414/cnp58384. [DOI] [PubMed] [Google Scholar]
  20. Kerr L. D., Spiera H. Scleroderma in association with the use of bleomycin: a report of 3 cases. J Rheumatol. 1992 Feb;19(2):294–296. [PubMed] [Google Scholar]
  21. Kono T., Ishii M., Negoro N., Taniguchi S. Scleroderma-like reaction induced by uracil-tegafur (UFT), a second-generation anticancer agent. J Am Acad Dermatol. 2000 Mar;42(3):519–520. doi: 10.1016/s0190-9622(00)90233-0. [DOI] [PubMed] [Google Scholar]
  22. Kyndt X., Hebbar M., Queyrel V., Hachulla E., Hatron P. Y., Devulder B. Sclérodermie systémique et cancer. Recherche de facteurs prédictifs de cancer chez 123 patients sclérodermiques. Rev Med Interne. 1997 Jul;18(7):528–532. doi: 10.1016/s0248-8663(97)80804-1. [DOI] [PubMed] [Google Scholar]
  23. Lynge E., Anttila A., Hemminki K. Organic solvents and cancer. Cancer Causes Control. 1997 May;8(3):406–419. doi: 10.1023/a:1018461406120. [DOI] [PubMed] [Google Scholar]
  24. Mattingly P. C., Mowat A. G. Rapidly progressive scleroderma associated with carcinoma of the oesophagus. Ann Rheum Dis. 1979 Apr;38(2):177–178. doi: 10.1136/ard.38.2.177. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Montagnino G., Lorca E., Tarantino A., Bencini P., Aroldi A., Cesana B., Braga M., Lonati F., Ponticelli C. Cancer incidence in 854 kidney transplant recipients from a single institution: comparison with normal population and with patients under dialytic treatment. Clin Transplant. 1996 Oct;10(5):461–469. [PubMed] [Google Scholar]
  26. Peters-Golden M., Wise R. A., Hochberg M., Stevens M. B., Wigley F. M. Incidence of lung cancer in systemic sclerosis. J Rheumatol. 1985 Dec;12(6):1136–1139. [PubMed] [Google Scholar]
  27. Rittner G., Schwanitz G., Baur M. P., Black C. M., Welsh K. I., Kühnl P., Rittner C. Family studies in scleroderma (systemic sclerosis) demonstrating an HLA-linked increased chromosomal breakage rate in cultured lymphocytes. Hum Genet. 1988 Dec;81(1):64–70. doi: 10.1007/BF00283732. [DOI] [PubMed] [Google Scholar]
  28. Rosenthal A. K., McLaughlin J. K., Gridley G., Nyrén O. Incidence of cancer among patients with systemic sclerosis. Cancer. 1995 Sep 1;76(5):910–914. doi: 10.1002/1097-0142(19950901)76:5<910::aid-cncr2820760528>3.0.co;2-t. [DOI] [PubMed] [Google Scholar]
  29. Rosenthal A. K., McLaughlin J. K., Linet M. S., Persson I. Scleroderma and malignancy: an epidemiological study. Ann Rheum Dis. 1993 Jul;52(7):531–533. doi: 10.1136/ard.52.7.531. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Rothfield N., Kurtzman S., Vazques-Abad D., Charron C., Daniels L., Greenberg B. Association of anti-topoisomerase I with cancer. Arthritis Rheum. 1992 Jun;35(6):724–724. doi: 10.1002/art.1780350621. [DOI] [PubMed] [Google Scholar]
  31. Roumm A. D., Medsger T. A., Jr Cancer and systemic sclerosis. An epidemiologic study. Arthritis Rheum. 1985 Dec;28(12):1336–1340. doi: 10.1002/art.1780281204. [DOI] [PubMed] [Google Scholar]
  32. Sahn E. E., Garen P. D., Silver R. M., Maize J. C. Scleroderma following augmentation mammoplasty. Report of a case and review of the literature. Arch Dermatol. 1990 Sep;126(9):1198–1202. doi: 10.1001/archderm.126.9.1198. [DOI] [PubMed] [Google Scholar]
  33. Sakkas L. I., Moore D. F., Akritidis N. C. Cancer in families with systemic sclerosis. Am J Med Sci. 1995 Dec;310(6):223–225. [PubMed] [Google Scholar]
  34. Spiera H., Kerr L. D. Scleroderma following silicone implantation: a cumulative experience of 11 cases. J Rheumatol. 1993 Jun;20(6):958–961. [PubMed] [Google Scholar]
  35. Talbott J. H., Barrocas M. Carcinoma of the lung in progressive systemic sclerosis: a tabular review of the literature and a detailed report of the roentgenographic changes in two cases. Semin Arthritis Rheum. 1980 Feb;9(3):191–217. doi: 10.1016/0049-0172(80)90007-4. [DOI] [PubMed] [Google Scholar]
  36. Tremblay Francine, Fernandes Myriam, Habbab Fadi, deB Edwardes Michael D., Loertscher Rolf, Meterissian Sarkis. Malignancy after renal transplantation: incidence and role of type of immunosuppression. Ann Surg Oncol. 2002 Oct;9(8):785–788. doi: 10.1007/BF02574501. [DOI] [PubMed] [Google Scholar]
  37. ZATUCHNI J., CAMPBELL W. N., ZARAFONETIS C. J. Pulmonary fibrosis and terminal bronchiolar (alveolar-cell) carcinoma in scleroderma. Cancer. 1953 Nov;6(6):1147–1158. doi: 10.1002/1097-0142(195311)6:6<1147::aid-cncr2820060605>3.0.co;2-l. [DOI] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES