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Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 2004 Apr 13;63(10):1186–1194. doi: 10.1136/ard.2004.020529

Chemokines in joint disease: the key to inflammation?

J Haringman 1, J Ludikhuize 1, P Tak 1
PMCID: PMC1754785  PMID: 15082471

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Figure 1.

Figure 1

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 Overview of homoeostatic and inflammatory functional interactions of chemokines and their receptors in inflammatory joint disease.

Figure 2.

Figure 2

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 Expression of chemokine and chemokine receptor staining in RA ST. CCR1 positive cells are scattered throughout the synovium, and are expressed predominantly by macrophages. There is marked CCR1 expression in the intimal lining layer. CCR2b is expressed by macrophages, especially in the synovial sublining. CCR5 is expressed by both T lymphocytes and macrophages. CXCR4 is mainly expressed by T lymphocytes in the synovial sublining. CCL2/MCP-1, a ligand for CCR2b is almost exclusively expressed in the intimal lining layer. CCL5/RANTES, a ligand for CCR1, CCR3, and CCR5 is expressed in both the intimal lining layer and the synovial sublining. (Single stain peroxidase technique, positive staining in red/brown, Mayer's haematoxylin counterstained, original magnifications x400).

Selected References

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