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Changes in (A) TJC, (B) SJC, and (C) C reactive protein levels (normal value <9 mg/l) of each patient during the respective treatment period. Infliximab treatment was stopped because of insufficient response (1) or allergic reaction (2). Disease exacerbation occurred when infliximab was stopped owing to herpes labialis infection (3). Shortening of the infliximab application interval to 4 weeks (4).
