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. 1997 Aug;65(8):3462–3464. doi: 10.1128/iai.65.8.3462-3464.1997

Role of vacuolating cytotoxin in gastritis due to Helicobacter pylori in gnotobiotic piglets.

K A Eaton 1, T L Cover 1, M K Tummuru 1, M J Blaser 1, S Krakowka 1
PMCID: PMC175490  PMID: 9234813

Abstract

To investigate the role of the Helicobacter pylori cytotoxin in the pathogenesis of gastritis, gnotobiotic piglets were colonized with either toxigenic H. pylori or a nontoxigenic isogenic mutant. Only piglets given the toxigenic strain developed toxin-neutralizing antibodies (indicating that toxin is expressed in vivo), but there was no difference in bacterial colonization, epithelial vacuolation, or gastritis between the two groups of piglets.

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Selected References

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