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. 2004 Apr;63(4):330–332. doi: 10.1136/ard.2003.015990

Unlocking the "PAD" lock on rheumatoid arthritis

P Utz 1, M Genovese 1, W Robinson 1
PMCID: PMC1754966  PMID: 15020322

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Selected References

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  1. Arbuckle Melissa R., McClain Micah T., Rubertone Mark V., Scofield R. Hal, Dennis Gregory J., James Judith A., Harley John B. Development of autoantibodies before the clinical onset of systemic lupus erythematosus. N Engl J Med. 2003 Oct 16;349(16):1526–1533. doi: 10.1056/NEJMoa021933. [DOI] [PubMed] [Google Scholar]
  2. Berger Thomas, Rubner Paul, Schautzer Franz, Egg Robert, Ulmer Hanno, Mayringer Irmgard, Dilitz Erika, Deisenhammer Florian, Reindl Markus. Antimyelin antibodies as a predictor of clinically definite multiple sclerosis after a first demyelinating event. N Engl J Med. 2003 Jul 10;349(2):139–145. doi: 10.1056/NEJMoa022328. [DOI] [PubMed] [Google Scholar]
  3. Girbal-Neuhauser E., Durieux J. J., Arnaud M., Dalbon P., Sebbag M., Vincent C., Simon M., Senshu T., Masson-Bessière C., Jolivet-Reynaud C. The epitopes targeted by the rheumatoid arthritis-associated antifilaggrin autoantibodies are posttranslationally generated on various sites of (pro)filaggrin by deimination of arginine residues. J Immunol. 1999 Jan 1;162(1):585–594. [PubMed] [Google Scholar]
  4. Hagopian W. A., Sanjeevi C. B., Kockum I., Landin-Olsson M., Karlsen A. E., Sundkvist G., Dahlquist G., Palmer J., Lernmark A. Glutamate decarboxylase-, insulin-, and islet cell-antibodies and HLA typing to detect diabetes in a general population-based study of Swedish children. J Clin Invest. 1995 Apr;95(4):1505–1511. doi: 10.1172/JCI117822. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Li Ning, Aoki Valeria, Hans-Filho Gunter, Rivitti Evandro A., Diaz Luis A. The role of intramolecular epitope spreading in the pathogenesis of endemic pemphigus foliaceus (fogo selvagem). J Exp Med. 2003 May 27;197(11):1501–1510. doi: 10.1084/jem.20022031. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. NIENHUIS R. L., MANDEMA E. A NEW SERUM FACTOR IN PATIENTS WITH RHEUMATOID ARTHRITIS; THE ANTIPERINUCLEAR FACTOR. Ann Rheum Dis. 1964 Jul;23:302–305. doi: 10.1136/ard.23.4.302. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Rantapä-Dahlqvist Solbritt, de Jong Ben A. W., Berglin Ewa, Hallmans Göran, Wadell Göran, Stenlund Hans, Sundin Ulf, van Venrooij Walther J. Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum. 2003 Oct;48(10):2741–2749. doi: 10.1002/art.11223. [DOI] [PubMed] [Google Scholar]
  8. Robinson William H., DiGennaro Carla, Hueber Wolfgang, Haab Brian B., Kamachi Makoto, Dean Erik J., Fournel Sylvie, Fong Derek, Genovese Mark C., de Vegvar Henry E. Neuman. Autoantigen microarrays for multiplex characterization of autoantibody responses. Nat Med. 2002 Mar;8(3):295–301. doi: 10.1038/nm0302-295. [DOI] [PubMed] [Google Scholar]
  9. Robinson William H., Fontoura Paulo, Lee Byung J., de Vegvar Henry E. Neuman, Tom Jennifer, Pedotti Rosetta, DiGennaro Carla D., Mitchell Dennis J., Fong Derek, Ho Peggy P-K. Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis. Nat Biotechnol. 2003 Aug 10;21(9):1033–1039. doi: 10.1038/nbt859. [DOI] [PubMed] [Google Scholar]
  10. Robinson William H., Steinman Lawrence, Utz Paul J. Protein arrays for autoantibody profiling and fine-specificity mapping. Proteomics. 2003 Nov;3(11):2077–2084. doi: 10.1002/pmic.200300583. [DOI] [PubMed] [Google Scholar]
  11. Schellekens G. A., de Jong B. A., van den Hoogen F. H., van de Putte L. B., van Venrooij W. J. Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies. J Clin Invest. 1998 Jan 1;101(1):273–281. doi: 10.1172/JCI1316. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Suzuki Akari, Yamada Ryo, Chang Xiaotian, Tokuhiro Shinya, Sawada Tetsuji, Suzuki Masakatsu, Nagasaki Miyuki, Nakayama-Hamada Makiko, Kawaida Reimi, Ono Mitsuru. Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis. Nat Genet. 2003 Aug;34(4):395–402. doi: 10.1038/ng1206. [DOI] [PubMed] [Google Scholar]
  13. Vossenaar E. R., Radstake T. R. D., van der Heijden A., van Mansum M. A. M., Dieteren C., de Rooij D-J, Barrera P., Zendman A. J. W., van Venrooij W. J. Expression and activity of citrullinating peptidylarginine deiminase enzymes in monocytes and macrophages. Ann Rheum Dis. 2004 Apr;63(4):373–381. doi: 10.1136/ard.2003.012211. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Young B. J., Mallya R. K., Leslie R. D., Clark C. J., Hamblin T. J. Anti-keratin antibodies in rheumatoid arthritis. Br Med J. 1979 Jul 14;2(6182):97–99. doi: 10.1136/bmj.2.6182.97. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. van Boekel Martinus A. M., Vossenaar Erik R., van den Hoogen Frank H. J., van Venrooij Walther J. Autoantibody systems in rheumatoid arthritis: specificity, sensitivity and diagnostic value. Arthritis Res. 2001 Nov 6;4(2):87–93. doi: 10.1186/ar395. [DOI] [PMC free article] [PubMed] [Google Scholar]

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