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Figure 1 .
Percentage of in vitro MTX-induced apoptosis of PBMC derived from patients with RA (means (SEM)). (A) Apoptosis of PBMC not activated with PHA. (B) Apoptosis of PHA activated cells. *Significant differences in comparison with the control (Wilcoxon matched pairs test). Differences in apoptosis (at the same MTX concentration) between all studied groups were analysed using Kruskal-Wallis analysis of variance test. No significant differences were found either for non-activated or PHA activated cells. MTX untreated = patients with RA before they started MTX treatment (n = 16); responders = patients with improvement of at least 20% according to ACR criteria (n = 13; six patients ⩾20% and seven patients ⩾50%); non-responders = patients without improvement (n = 10).