Skip to main content
PMC home page
Infection and Immunity logoLink to Infection and Immunity
. 1997 Sep;65(9):3501–3508. doi: 10.1128/iai.65.9.3501-3508.1997

Mast cells in infection and immunity.

S N Abraham 1, R Malaviya 1
PMCID: PMC175499  PMID: 9284112

Full Text

The Full Text of this article is available as a PDF (157.2 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abraham S. N., Sun D., Dale J. B., Beachey E. H. Conservation of the D-mannose-adhesion protein among type 1 fimbriated members of the family Enterobacteriaceae. Nature. 1988 Dec 15;336(6200):682–684. doi: 10.1038/336682a0. [DOI] [PubMed] [Google Scholar]
  2. Abramson J. S., Dahl M. V., Walsh G., Blumenthal M. N., Douglas S. D., Quie P. G. Antistaphylococcal IgE in patients with atopic dermatitis. J Am Acad Dermatol. 1982 Jul;7(1):105–110. doi: 10.1016/s0190-9622(82)80017-0. [DOI] [PubMed] [Google Scholar]
  3. Aceti A., Celestino D., Caferro M., Casale V., Citarda F., Conti E. M., Grassi A., Grilli A., Pennica A., Sciarretta F. Basophil-bound and serum immunoglobulin E directed against Helicobacter pylori in patients with chronic gastritis. Gastroenterology. 1991 Jul;101(1):131–137. doi: 10.1016/0016-5085(91)90469-2. [DOI] [PubMed] [Google Scholar]
  4. Baggiolini M., Walz A., Kunkel S. L. Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils. J Clin Invest. 1989 Oct;84(4):1045–1049. doi: 10.1172/JCI114265. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Barrett K. E. Effect of histamine and other mast cell mediators on T84 epithelial cells. Ann N Y Acad Sci. 1992;664:222–231. doi: 10.1111/j.1749-6632.1992.tb39763.x. [DOI] [PubMed] [Google Scholar]
  6. Barrett K. E. Immune-related intestinal chloride secretion. III. Acute and chronic effects of mast cell mediators on chloride secretion by a human colonic epithelial cell line. J Immunol. 1991 Aug 1;147(3):959–964. [PubMed] [Google Scholar]
  7. Bradding P., Okayama Y., Howarth P. H., Church M. K., Holgate S. T. Heterogeneity of human mast cells based on cytokine content. J Immunol. 1995 Jul 1;155(1):297–307. [PubMed] [Google Scholar]
  8. Cairns J. A., Walls A. F. Mast cell tryptase is a mitogen for epithelial cells. Stimulation of IL-8 production and intercellular adhesion molecule-1 expression. J Immunol. 1996 Jan 1;156(1):275–283. [PubMed] [Google Scholar]
  9. Church M. K., Norn S., Pao G. J., Holgate S. T. Non-IgE-dependent bacteria-induced histamine release from human lung and tonsillar mast cells. Clin Allergy. 1987 Jul;17(4):341–353. doi: 10.1111/j.1365-2222.1987.tb02024.x. [DOI] [PubMed] [Google Scholar]
  10. Clementsen P., Larsen F. O., Milman N., Skov P. S., Norn S. Haemophilus influenzae release histamine and enhance histamine release from human bronchoalveolar cells. Examination of patients with chronic bronchitis and controls. APMIS. 1995 Nov;103(11):806–812. [PubMed] [Google Scholar]
  11. Columbo M., Bochner B. S., Marone G. Human mast cells adhere to extracellular matrix proteins through their selective expression of beta 1 integrins. Int Arch Allergy Immunol. 1995 May-Jun;107(1-3):336–337. doi: 10.1159/000237020. [DOI] [PubMed] [Google Scholar]
  12. Crowe S. E., Perdue M. H. Functional abnormalities in the intestine associated with mucosal mast cell activation. Reg Immunol. 1992 Mar-Apr;4(2):113–117. [PubMed] [Google Scholar]
  13. Crowle P. K. Mucosal mast cell reconstitution and Nippostrongylus brasiliensis rejection by W/Wv mice. J Parasitol. 1983 Feb;69(1):66–69. [PubMed] [Google Scholar]
  14. Dvorak A. M., Tepper R. I., Weller P. F., Morgan E. S., Estrella P., Monahan-Earley R. A., Galli S. J. Piecemeal degranulation of mast cells in the inflammatory eyelid lesions of interleukin-4 transgenic mice. Evidence of mast cell histamine release in vivo by diamine oxidase-gold enzyme-affinity ultrastructural cytochemistry. Blood. 1994 Jun 15;83(12):3600–3612. [PubMed] [Google Scholar]
  15. Echtenacher B., Männel D. N., Hültner L. Critical protective role of mast cells in a model of acute septic peritonitis. Nature. 1996 May 2;381(6577):75–77. doi: 10.1038/381075a0. [DOI] [PubMed] [Google Scholar]
  16. Finkelman F. D., Katona I. M., Urban J. F., Jr, Paul W. E. Control of in vivo IgE production in the mouse by interleukin 4. Ciba Found Symp. 1989;147:3–22. doi: 10.1002/9780470513866.ch2. [DOI] [PubMed] [Google Scholar]
  17. Finkelman F. D., Pearce E. J., Urban J. F., Jr, Sher A. Regulation and biological function of helminth-induced cytokine responses. Immunol Today. 1991 Mar;12(3):A62–A66. doi: 10.1016/S0167-5699(05)80018-0. [DOI] [PubMed] [Google Scholar]
  18. Frandji P., Tkaczyk C., Oskeritzian C., David B., Desaymard C., Mécheri S. Exogenous and endogenous antigens are differentially presented by mast cells to CD4+ T lymphocytes. Eur J Immunol. 1996 Oct;26(10):2517–2528. doi: 10.1002/eji.1830261036. [DOI] [PubMed] [Google Scholar]
  19. Friedl P., König B., König W. Effects of mucoid and non-mucoid Pseudomonas aeruginosa isolates from cystic fibrosis patients on inflammatory mediator release from human polymorphonuclear granulocytes and rat mast cells. Immunology. 1992 May;76(1):86–94. [PMC free article] [PubMed] [Google Scholar]
  20. Galli S. J., Gordon J. R., Wershil B. K. Cytokine production by mast cells and basophils. Curr Opin Immunol. 1991 Dec;3(6):865–872. doi: 10.1016/s0952-7915(05)80005-6. [DOI] [PubMed] [Google Scholar]
  21. Galli S. J. New approaches for the analysis of mast cell maturation, heterogeneity, and function. Fed Proc. 1987 Apr;46(5):1906–1914. [PubMed] [Google Scholar]
  22. Galli S. J. New concepts about the mast cell. N Engl J Med. 1993 Jan 28;328(4):257–265. doi: 10.1056/NEJM199301283280408. [DOI] [PubMed] [Google Scholar]
  23. Galli S. J. New insights into "the riddle of the mast cells": microenvironmental regulation of mast cell development and phenotypic heterogeneity. Lab Invest. 1990 Jan;62(1):5–33. [PubMed] [Google Scholar]
  24. Galli S. J., Wershil B. K. The two faces of the mast cell. Nature. 1996 May 2;381(6577):21–22. doi: 10.1038/381021a0. [DOI] [PubMed] [Google Scholar]
  25. Galli S. J., Zsebo K. M., Geissler E. N. The kit ligand, stem cell factor. Adv Immunol. 1994;55:1–96. doi: 10.1016/s0065-2776(08)60508-8. [DOI] [PubMed] [Google Scholar]
  26. Gordon J. R., Galli S. J. Release of both preformed and newly synthesized tumor necrosis factor alpha (TNF-alpha)/cachectin by mouse mast cells stimulated via the Fc epsilon RI. A mechanism for the sustained action of mast cell-derived TNF-alpha during IgE-dependent biological responses. J Exp Med. 1991 Jul 1;174(1):103–107. doi: 10.1084/jem.174.1.103. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Gounni A. S., Lamkhioued B., Ochiai K., Tanaka Y., Delaporte E., Capron A., Kinet J. P., Capron M. High-affinity IgE receptor on eosinophils is involved in defence against parasites. Nature. 1994 Jan 13;367(6459):183–186. doi: 10.1038/367183a0. [DOI] [PubMed] [Google Scholar]
  28. Gross-Weege W., König W., Scheffer J., Nimmich W. Induction of histamine release from rat mast cells and human basophilic granulocytes by clinical Escherichia coli isolates and relation to hemolysin production and adhesin expression. J Clin Microbiol. 1988 Sep;26(9):1831–1837. doi: 10.1128/jcm.26.9.1831-1837.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Hebda P. A., Collins M. A., Tharp M. D. Mast cell and myofibroblast in wound healing. Dermatol Clin. 1993 Oct;11(4):685–696. [PubMed] [Google Scholar]
  30. Heggers J. P., Haydon S., Ko F., Hayward P. G., Carp S., Robson M. C. Pseudomonas aeruginosa exotoxin A: its role in retardation of wound healing: the 1992 Lindberg Award. J Burn Care Rehabil. 1992 Sep-Oct;13(5):512–518. [PubMed] [Google Scholar]
  31. Henderson B., Poole S., Wilson M. Bacterial modulins: a novel class of virulence factors which cause host tissue pathology by inducing cytokine synthesis. Microbiol Rev. 1996 Jun;60(2):316–341. doi: 10.1128/mr.60.2.316-341.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Håkanson R., Böttcher G., Ekblad E., Panula P., Simonsson M., Dohlsten M., Hallberg T., Sundler F. Histamine in endocrine cells in the stomach. A survey of several species using a panel of histamine antibodies. Histochemistry. 1986;86(1):5–17. doi: 10.1007/BF00492340. [DOI] [PubMed] [Google Scholar]
  33. Jensen C., Norn S., Stahl Skov P., Espersen F., Koch C., Permin H. Bacterial histamine release by immunological and non-immunological lectin-mediated reactions. Allergy. 1984 Jul;39(5):371–377. doi: 10.1111/j.1398-9995.1984.tb01955.x. [DOI] [PubMed] [Google Scholar]
  34. Kaminer M. S., Murphy G. F., Zweiman B., Lavker R. M. Connective tissue mast cells exhibit time-dependent degranulation heterogeneity. Clin Diagn Lab Immunol. 1995 May;2(3):297–301. doi: 10.1128/cdli.2.3.297-301.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Katz H. R., Raizman M. B., Gartner C. S., Scott H. C., Benson A. C., Austen K. F. Secretory granule mediator release and generation of oxidative metabolites of arachidonic acid via Fc-IgG receptor bridging in mouse mast cells. J Immunol. 1992 Feb 1;148(3):868–871. [PubMed] [Google Scholar]
  36. Klimpel G. R., Chopra A. K., Langley K. E., Wypych J., Annable C. A., Kaiserlian D., Ernst P. B., Peterson J. W. A role for stem cell factor and c-kit in the murine intestinal tract secretory response to cholera toxin. J Exp Med. 1995 Dec 1;182(6):1931–1942. doi: 10.1084/jem.182.6.1931. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Klimpel G. R., Langley K. E., Wypych J., Abrams J. S., Chopra A. K., Niesel D. W. A role for stem cell factor (SCF): c-kit interaction(s) in the intestinal tract response to Salmonella typhimurium infection. J Exp Med. 1996 Jul 1;184(1):271–276. doi: 10.1084/jem.184.1.271. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. Kovacsovics-Bankowski M., Rock K. L. A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class I molecules. Science. 1995 Jan 13;267(5195):243–246. doi: 10.1126/science.7809629. [DOI] [PubMed] [Google Scholar]
  39. König B., König W., Scheffer J., Hacker J., Goebel W. Role of Escherichia coli alpha-hemolysin and bacterial adherence in infection: requirement for release of inflammatory mediators from granulocytes and mast cells. Infect Immun. 1986 Dec;54(3):886–892. doi: 10.1128/iai.54.3.886-892.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. König W., Faltin Y., Scheffer J., Schöffler H., Braun V. Role of cell-bound hemolysin as a pathogenicity factor for Serratia infections. Infect Immun. 1987 Nov;55(11):2554–2561. doi: 10.1128/iai.55.11.2554-2561.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. Leal-Berumen I., Conlon P., Marshall J. S. IL-6 production by rat peritoneal mast cells is not necessarily preceded by histamine release and can be induced by bacterial lipopolysaccharide. J Immunol. 1994 Jun 1;152(11):5468–5476. [PubMed] [Google Scholar]
  42. Leal-Berumen I., Snider D. P., Barajas-Lopez C., Marshall J. S. Cholera toxin increases IL-6 synthesis and decreases TNF-alpha production by rat peritoneal mast cells. J Immunol. 1996 Jan 1;156(1):316–321. [PubMed] [Google Scholar]
  43. Leung D. Y., Harbeck R., Bina P., Reiser R. F., Yang E., Norris D. A., Hanifin J. M., Sampson H. A. Presence of IgE antibodies to staphylococcal exotoxins on the skin of patients with atopic dermatitis. Evidence for a new group of allergens. J Clin Invest. 1993 Sep;92(3):1374–1380. doi: 10.1172/JCI116711. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. Lukacs N. W., Strieter R. M., Chensue S. W., Kunkel S. L. Activation and regulation of chemokines in allergic airway inflammation. J Leukoc Biol. 1996 Jan;59(1):13–17. doi: 10.1002/jlb.59.1.13. [DOI] [PubMed] [Google Scholar]
  45. Lutton D. A., Bamford K. B., O'Loughlin B., Ennis M. Modulatory action of Helicobacter pylori on histamine release from mast cells and basophils in vitro. J Med Microbiol. 1995 Jun;42(6):386–393. doi: 10.1099/00222615-42-6-386. [DOI] [PubMed] [Google Scholar]
  46. Malaviya R., Ikeda T., Ross E., Abraham S. N. Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-alpha. Nature. 1996 May 2;381(6577):77–80. doi: 10.1038/381077a0. [DOI] [PubMed] [Google Scholar]
  47. Malaviya R., Malaviya R., Jakschik B. A. Reversible translocation of 5-lipoxygenase in mast cells upon IgE/antigen stimulation. J Biol Chem. 1993 Mar 5;268(7):4939–4944. [PubMed] [Google Scholar]
  48. Malaviya R., Ross E. A., MacGregor J. I., Ikeda T., Little J. R., Jakschik B. A., Abraham S. N. Mast cell phagocytosis of FimH-expressing enterobacteria. J Immunol. 1994 Feb 15;152(4):1907–1914. [PubMed] [Google Scholar]
  49. Malaviya R., Ross E., Jakschik B. A., Abraham S. N. Mast cell degranulation induced by type 1 fimbriated Escherichia coli in mice. J Clin Invest. 1994 Apr;93(4):1645–1653. doi: 10.1172/JCI117146. [DOI] [PMC free article] [PubMed] [Google Scholar]
  50. Malaviya R., Twesten N. J., Ross E. A., Abraham S. N., Pfeifer J. D. Mast cells process bacterial Ags through a phagocytic route for class I MHC presentation to T cells. J Immunol. 1996 Feb 15;156(4):1490–1496. [PubMed] [Google Scholar]
  51. Matsuda H., Watanabe N., Kiso Y., Hirota S., Ushio H., Kannan Y., Azuma M., Koyama H., Kitamura Y. Necessity of IgE antibodies and mast cells for manifestation of resistance against larval Haemaphysalis longicornis ticks in mice. J Immunol. 1990 Jan 1;144(1):259–262. [PubMed] [Google Scholar]
  52. Matsuda K., Aoki J., Uchida M. K., Suzuki-Nishimura T. Datura stramonium agglutinin released histamine from rat peritoneal mast cells that was inhibited by pertussis toxin, haptenic sugar and N-acetylglucosamine-specific lectins: involvement of glycoproteins with N-acetylglucosamine residues. Jpn J Pharmacol. 1994 Oct;66(2):195–204. doi: 10.1254/jjp.66.195. [DOI] [PubMed] [Google Scholar]
  53. Metzger H. The high affinity receptor for IgE on mast cells. Clin Exp Allergy. 1991 May;21(3):269–279. doi: 10.1111/j.1365-2222.1991.tb01658.x. [DOI] [PubMed] [Google Scholar]
  54. Miller H. R., Newlands G. F., McKellar A., Inglis L., Coulson P. S., Wilson R. A. Hepatic recruitment of mast cells occurs in rats but not mice infected with Schistosoma mansoni. Parasite Immunol. 1994 Mar;16(3):145–155. doi: 10.1111/j.1365-3024.1994.tb00334.x. [DOI] [PubMed] [Google Scholar]
  55. Miner P. B., Jr The role of the mast cell in clinical gastrointestinal disease with special reference to systemic mastocytosis. J Invest Dermatol. 1991 Mar;96(3 Suppl):40S-43S; discussion 43S-44S, 60S-65S. doi: 10.1111/1523-1747.ep12469015. [DOI] [PubMed] [Google Scholar]
  56. Newlands G. F., Miller H. R., MacKellar A., Galli S. J. Stem cell factor contributes to intestinal mucosal mast cell hyperplasia in rats infected with Nippostrongylus brasiliensis or Trichinella spiralis, but anti-stem cell factor treatment decreases parasite egg production during N brasiliensis infection. Blood. 1995 Sep 1;86(5):1968–1976. [PubMed] [Google Scholar]
  57. Norn S., Stahl Skov P., Jensen C., Bøg-Hansen T. C., Lihme A., Espersen F., Permin H. Lectin-mediated reactions in histamine release caused by bacteria. Agents Actions. 1984 Apr;14(3-4):481–483. doi: 10.1007/BF01973854. [DOI] [PubMed] [Google Scholar]
  58. Nygren H., Dahlén G. Complement-dependent histamine release from rat peritoneal mast cells, induced by lipopolysaccharides from Bacteroides oralis, Fusobacterium nucleatum and Veillonella parvula. J Oral Pathol. 1981 Apr;10(2):87–94. doi: 10.1111/j.1600-0714.1981.tb01253.x. [DOI] [PubMed] [Google Scholar]
  59. Pfeifer J. D., Wick M. J., Roberts R. L., Findlay K., Normark S. J., Harding C. V. Phagocytic processing of bacterial antigens for class I MHC presentation to T cells. Nature. 1993 Jan 28;361(6410):359–362. doi: 10.1038/361359a0. [DOI] [PubMed] [Google Scholar]
  60. Pothoulakis C., Castagliuolo I., LaMont J. T., Jaffer A., O'Keane J. C., Snider R. M., Leeman S. E. CP-96,345, a substance P antagonist, inhibits rat intestinal responses to Clostridium difficile toxin A but not cholera toxin. Proc Natl Acad Sci U S A. 1994 Feb 1;91(3):947–951. doi: 10.1073/pnas.91.3.947. [DOI] [PMC free article] [PubMed] [Google Scholar]
  61. Rodewald H. R., Dessing M., Dvorak A. M., Galli S. J. Identification of a committed precursor for the mast cell lineage. Science. 1996 Feb 9;271(5250):818–822. doi: 10.1126/science.271.5250.818. [DOI] [PubMed] [Google Scholar]
  62. Romagnani S. Regulation and deregulation of human IgE synthesis. Immunol Today. 1990 Sep;11(9):316–321. doi: 10.1016/s0167-5699(10)80004-0. [DOI] [PubMed] [Google Scholar]
  63. Scheffer J., König W., Braun V., Goebel W. Comparison of four hemolysin-producing organisms (Escherichia coli, Serratia marcescens, Aeromonas hydrophila, and Listeria monocytogenes) for release of inflammatory mediators from various cells. J Clin Microbiol. 1988 Mar;26(3):544–551. doi: 10.1128/jcm.26.3.544-551.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  64. Scheffer J., Vosbeck K., König W. Induction of inflammatory mediators from human polymorphonuclear granulocytes and rat mast cells by haemolysin-positive and -negative E. coli strains with different adhesins. Immunology. 1986 Dec;59(4):541–548. [PMC free article] [PubMed] [Google Scholar]
  65. Sher A. Complement-dependent adherence of mast cells to schistosomula. Nature. 1976 Sep 23;263(5575):334–336. doi: 10.1038/263334a0. [DOI] [PubMed] [Google Scholar]
  66. Sher A., Hein A., Moser G., Caulfield J. P. Complement receptors promote the phagocytosis of bacteria by rat peritoneal mast cells. Lab Invest. 1979 Dec;41(6):490–499. [PubMed] [Google Scholar]
  67. Sher A., McIntyre S. L. Receptors for C3 on rat peritoneal mast cells. J Immunol. 1977 Aug;119(2):722–725. [PubMed] [Google Scholar]
  68. Smith T. J., Ducharme L. A., Weis J. H. Preferential expression of interleukin-12 or interleukin-4 by murine bone marrow mast cells derived in mast cell growth factor or interleukin-3. Eur J Immunol. 1994 Apr;24(4):822–826. doi: 10.1002/eji.1830240408. [DOI] [PubMed] [Google Scholar]
  69. Stechschulte D. J., Jr, Morris D. C., Jilka R. L., Stechschulte D. J., Dileepan K. N. Impaired gastric acid secretion in mast cell-deficient mice. Am J Physiol. 1990 Jul;259(1 Pt 1):G41–G47. doi: 10.1152/ajpgi.1990.259.1.G41. [DOI] [PubMed] [Google Scholar]
  70. Sugimoto K., Kasuga F., Kumagai S. Effects of B subunit of cholera toxin on histamine release from rat peritoneal mast cells. Int Arch Allergy Immunol. 1994 Oct;105(2):195–197. doi: 10.1159/000236825. [DOI] [PubMed] [Google Scholar]
  71. Valent P. Cytokines involved in growth and differentiation of human basophils and mast cells. Exp Dermatol. 1995 Aug;4(4 Pt 2):255–259. doi: 10.1111/j.1600-0625.1995.tb00254.x. [DOI] [PubMed] [Google Scholar]
  72. Wasserman S. I. Mast cell-mediated inflammation in asthma. Ann Allergy. 1989 Dec;63(6 Pt 2):546–550. [PubMed] [Google Scholar]
  73. Wershil B. K., Theodos C. M., Galli S. J., Titus R. G. Mast cells augment lesion size and persistence during experimental Leishmania major infection in the mouse. J Immunol. 1994 May 1;152(9):4563–4571. [PubMed] [Google Scholar]
  74. Wojtecka-Lukasik E., Maśliński S. Fibronectin and fibrinogen degradation products stimulate PMN-leukocyte and mast cell degranulation. J Physiol Pharmacol. 1992 Jun;43(2):173–181. [PubMed] [Google Scholar]
  75. Zhang Y., Ramos B. F., Jakschik B. A. Neutrophil recruitment by tumor necrosis factor from mast cells in immune complex peritonitis. Science. 1992 Dec 18;258(5090):1957–1959. doi: 10.1126/science.1470922. [DOI] [PubMed] [Google Scholar]
  76. Zheutlin L. M., Ackerman S. J., Gleich G. J., Thomas L. L. Stimulation of basophil and rat mast cell histamine release by eosinophil granule-derived cationic proteins. J Immunol. 1984 Oct;133(4):2180–2185. [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES