Abstract
Objective: To explore the associations between individual subdimensions of the health assessment questionnaire (HAQ) and clinical variables in patients with rheumatoid arthritis.
Methods: 304 patients with rheumatoid arthritis (73% female, mean (SD) age, 58 (13) years; disease duration 6 (9) years, 69% rheumatoid factor positive) completed the HAQ for functional capacity (0–3) and a 100 mm visual analogue scale for pain. Grip strength, range of motion of the large joints, Larsen score for radiographic damage of hand and foot joints, and the number of tender and swollen joints were recorded. A logit regression model was used to study associations between subdimensions of the HAQ and other variables.
Results: Mean (range) total HAQ score was 0.92 (0 to 2.88) and varied from 0.73 to 1.04 in the subdimensions. Disability was lowest in the "walking" and highest in the "reach" subdimension. Pain was an explanatory variable in all individual subdimensions. Decreased grip strength, limitation of shoulder and wrist motion, and a larger number of swollen and tender joints in the upper extremities were related to several subdimensions. A higher pain score and swollen joint count in the upper extremities, decreased grip strength, and limited motion of wrist, shoulder, and knee joints explained increased disability (higher total HAQ scores).
Conclusions: In patients with rheumatoid arthritis, pain and range of movements of joints have the greatest impact on individual subdimensions of the HAQ. Extent of radiographic damage in peripheral joints and the number of swollen and tender joints are of lesser importance for function.
Full Text
The Full Text of this article is available as a PDF (66.9 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Badley E. M., Wagstaff S., Wood P. H. Measures of functional ability (disability) in arthritis in relation to impairment of range of joint movement. Ann Rheum Dis. 1984 Aug;43(4):563–569. doi: 10.1136/ard.43.4.563. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Boström C. Shoulder rotational strength, movement, pain and joint tenderness as indicators of upper-extremity activity limitation in moderate rheumatoid arthritis. Scand J Rehabil Med. 2000 Sep;32(3):134–139. doi: 10.1080/003655000750045488. [DOI] [PubMed] [Google Scholar]
- Bruce Bonnie, Fries James F. The Stanford Health Assessment Questionnaire: a review of its history, issues, progress, and documentation. J Rheumatol. 2003 Jan;30(1):167–178. [PubMed] [Google Scholar]
- Callahan L. F., Bloch D. A., Pincus T. Identification of work disability in rheumatoid arthritis: physical, radiographic and laboratory variables do not add explanatory power to demographic and functional variables. J Clin Epidemiol. 1992 Feb;45(2):127–138. doi: 10.1016/0895-4356(92)90005-8. [DOI] [PubMed] [Google Scholar]
- Clarke A. E., St-Pierre Y., Joseph L., Penrod J., Sibley J. T., Haga M., Genant H. K. Radiographic damage in rheumatoid arthritis correlates with functional disability but not direct medical costs. J Rheumatol. 2001 Nov;28(11):2416–2424. [PubMed] [Google Scholar]
- Corbin C. B. Flexibility. Clin Sports Med. 1984 Jan;3(1):101–117. [PubMed] [Google Scholar]
- Drossaers-Bakker K. W., Kroon H. M., Zwinderman A. H., Breedveld F. C., Hazes J. M. Radiographic damage of large joints in long-term rheumatoid arthritis and its relation to function. Rheumatology (Oxford) 2000 Sep;39(9):998–1003. doi: 10.1093/rheumatology/39.9.998. [DOI] [PubMed] [Google Scholar]
- Escalante A., del Rincón I. How much disability in rheumatoid arthritis is explained by rheumatoid arthritis? Arthritis Rheum. 1999 Aug;42(8):1712–1721. doi: 10.1002/1529-0131(199908)42:8<1712::AID-ANR21>3.0.CO;2-X. [DOI] [PubMed] [Google Scholar]
- Ferraz M. B., Oliveira L. M., Araujo P. M., Atra E., Walter S. D. EPM-ROM Scale: an evaluative instrument to be used in rheumatoid arthritis trials. Clin Exp Rheumatol. 1990 Sep-Oct;8(5):491–494. [PubMed] [Google Scholar]
- Fries J. F., Spitz P. W., Young D. Y. The dimensions of health outcomes: the health assessment questionnaire, disability and pain scales. J Rheumatol. 1982 Sep-Oct;9(5):789–793. [PubMed] [Google Scholar]
- Fries J. F., Spitz P., Kraines R. G., Holman H. R. Measurement of patient outcome in arthritis. Arthritis Rheum. 1980 Feb;23(2):137–145. doi: 10.1002/art.1780230202. [DOI] [PubMed] [Google Scholar]
- Guillemin F., Suurmeijer T., Krol B., Bombardier C., Briançon S., Doeglas D., Sanderman R., van den Heuvel W. Functional disability in early rheumatoid arthritis: description and risk factors. J Rheumatol. 1994 Jun;21(6):1051–1055. [PubMed] [Google Scholar]
- Hakala M., Nieminen P., Koivisto O. More evidence from a community based series of better outcome in rheumatoid arthritis. Data on the effect of multidisciplinary care on the retention of functional ability. J Rheumatol. 1994 Aug;21(8):1432–1437. [PubMed] [Google Scholar]
- Heiberg Turid, Kvien Tore K. Preferences for improved health examined in 1,024 patients with rheumatoid arthritis: pain has highest priority. Arthritis Rheum. 2002 Aug;47(4):391–397. doi: 10.1002/art.10515. [DOI] [PubMed] [Google Scholar]
- Jäntti J. K., Kaarela K., Luukkainen R. K., Kautiainen H. J. Prediction of 20-year outcome at onset of seropositive rheumatoid arthritis. Clin Exp Rheumatol. 2000 May-Jun;18(3):387–390. [PubMed] [Google Scholar]
- Larsen A., Dale K., Eek M. Radiographic evaluation of rheumatoid arthritis and related conditions by standard reference films. Acta Radiol Diagn (Stockh) 1977 Jul;18(4):481–491. doi: 10.1177/028418517701800415. [DOI] [PubMed] [Google Scholar]
- Larsen A. How to apply Larsen score in evaluating radiographs of rheumatoid arthritis in long-term studies. J Rheumatol. 1995 Oct;22(10):1974–1975. [PubMed] [Google Scholar]
- Molenaar Esmeralda T. H., Voskuyl Alexandre E., Dijkmans Ben A. C. Functional disability in relation to radiological damage and disease activity in patients with rheumatoid arthritis in remission. J Rheumatol. 2002 Feb;29(2):267–270. [PubMed] [Google Scholar]
- Pincus T., Callahan L. F., Brooks R. H., Fuchs H. A., Olsen N. J., Kaye J. J. Self-report questionnaire scores in rheumatoid arthritis compared with traditional physical, radiographic, and laboratory measures. Ann Intern Med. 1989 Feb 15;110(4):259–266. doi: 10.7326/0003-4819-110-4-259. [DOI] [PubMed] [Google Scholar]
- Pincus T., Callahan L. F. Rheumatology function tests: grip strength, walking time, button test and questionnaires document and predict longterm morbidity and mortality in rheumatoid arthritis. J Rheumatol. 1992 Jul;19(7):1051–1057. [PubMed] [Google Scholar]
- Pincus T., Callahan L. F., Vaughn W. K. Questionnaire, walking time and button test measures of functional capacity as predictive markers for mortality in rheumatoid arthritis. J Rheumatol. 1987 Apr;14(2):240–251. [PubMed] [Google Scholar]
- Pincus T., Summey J. A., Soraci S. A., Jr, Wallston K. A., Hummon N. P. Assessment of patient satisfaction in activities of daily living using a modified Stanford Health Assessment Questionnaire. Arthritis Rheum. 1983 Nov;26(11):1346–1353. doi: 10.1002/art.1780261107. [DOI] [PubMed] [Google Scholar]
- Pincus Theodore, Sokka Tuulikki. Quantitative measures for assessing rheumatoid arthritis in clinical trials and clinical care. Best Pract Res Clin Rheumatol. 2003 Oct;17(5):753–781. doi: 10.1016/s1521-6942(03)00077-9. [DOI] [PubMed] [Google Scholar]
- Price D. D., McGrath P. A., Rafii A., Buckingham B. The validation of visual analogue scales as ratio scale measures for chronic and experimental pain. Pain. 1983 Sep;17(1):45–56. doi: 10.1016/0304-3959(83)90126-4. [DOI] [PubMed] [Google Scholar]
- Rau R., Herborn G., Fenner H. Links between joint damage and disability. Rheumatology (Oxford) 2000 Dec;39(12):1434–1435. doi: 10.1093/rheumatology/39.12.1434. [DOI] [PubMed] [Google Scholar]
- Sarzi-Puttini Piercarlo, Fiorini Tania, Panni Benedetta, Turiel Maurizio, Cazzola Marco, Atzeni Fabiola. Correlation of the score for subjective pain with physical disability, clinical and radiographic scores in recent onset rheumatoid arthritis. BMC Musculoskelet Disord. 2002 Jul 19;3:18–18. doi: 10.1186/1471-2474-3-18. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sokka T., Kankainen A., Hannonen P. Scores for functional disability in patients with rheumatoid arthritis are correlated at higher levels with pain scores than with radiographic scores. Arthritis Rheum. 2000 Feb;43(2):386–389. doi: 10.1002/1529-0131(200002)43:2<386::AID-ANR19>3.0.CO;2-Z. [DOI] [PubMed] [Google Scholar]
- Sokka Tuulikki. Assessment of pain in patients with rheumatic diseases. Best Pract Res Clin Rheumatol. 2003 Jun;17(3):427–449. doi: 10.1016/s1521-6942(03)00020-2. [DOI] [PubMed] [Google Scholar]
- Stenström Christina H., Minor Marian A. Evidence for the benefit of aerobic and strengthening exercise in rheumatoid arthritis. Arthritis Rheum. 2003 Jun 15;49(3):428–434. doi: 10.1002/art.11051. [DOI] [PubMed] [Google Scholar]
- Stratford Paul W., Kennedy Deborah, Pagura Sonia M. C., Gollish Jeffrey D. The relationship between self-report and performance-related measures: questioning the content validity of timed tests. Arthritis Rheum. 2003 Aug 15;49(4):535–540. doi: 10.1002/art.11196. [DOI] [PubMed] [Google Scholar]
- Stratford Paul W., Kennedy Deborah, Pagura Sonia M. C., Gollish Jeffrey D. The relationship between self-report and performance-related measures: questioning the content validity of timed tests. Arthritis Rheum. 2003 Aug 15;49(4):535–540. doi: 10.1002/art.11196. [DOI] [PubMed] [Google Scholar]
- Vliet Vlieland T. P., van den Ende C. H., Breedveld F. C., Hazes J. M. Evaluation of joint mobility in rheumatoid arthritis trials: the value of the EPM-range of motion scale. J Rheumatol. 1993 Dec;20(12):2010–2014. [PubMed] [Google Scholar]
- Ward M. M., Leigh J. P. The relative importance of pain and functional disability to patients with rheumatoid arthritis. J Rheumatol. 1993 Sep;20(9):1494–1499. [PubMed] [Google Scholar]
- Welsing P. M., van Gestel A. M., Swinkels H. L., Kiemeney L. A., van Riel P. L. The relationship between disease activity, joint destruction, and functional capacity over the course of rheumatoid arthritis. Arthritis Rheum. 2001 Sep;44(9):2009–2017. doi: 10.1002/1529-0131(200109)44:9<2009::AID-ART349>3.0.CO;2-L. [DOI] [PubMed] [Google Scholar]
- Wolfe F., Hawley D. J., Cathey M. A. Clinical and health status measures over time: prognosis and outcome assessment in rheumatoid arthritis. J Rheumatol. 1991 Sep;18(9):1290–1297. [PubMed] [Google Scholar]