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. 1997 Sep;65(9):3936–3938. doi: 10.1128/iai.65.9.3936-3938.1997

Allelic variation in Streptococcus pneumoniae autolysin (N-acetyl muramoyl-L-alanine amidase).

S H Gillespie 1, T D McHugh 1, H Ayres 1, A Dickens 1, A Efstratiou 1, G C Whiting 1
PMCID: PMC175561  PMID: 9284174

Abstract

The lytA gene encoding the autolysin of Streptococcus pneumoniae may be a virulence determinant. Single-strand conformational polymorphism analysis demonstrated heterogenicity throughout the gene in clinical isolates and strains from the clonal serotypes 7 and 14. Sequence analysis of part of the choline-binding domain showed that in two isolates four amino acid substitutions occurred.

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Selected References

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