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. 1997 Sep;65(9):3947–3950. doi: 10.1128/iai.65.9.3947-3950.1997

Activation of CD8 T cells with specificity for mycobacterial heat shock protein 60 in Mycobacterium bovis bacillus Calmette-Guérin-vaccinated mice.

U Zügel 1, S H Kaufmann 1
PMCID: PMC175564  PMID: 9284177

Abstract

Heat shock protein 60 (hsp60)-specific CD8 T cells lysed Mycobacterium bovis BCG-infected macrophages in vitro and adoptively transferred protection against mycobacterial infection. Moreover, CD8 T cells with this hsp60 specificity were activated in vivo by BCG vaccination. Our studies suggest there is participation of hsp60-specific CD8 T cells in BCG-induced immunity.

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Selected References

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