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. 1999 Feb;33(1):27–32. doi: 10.1136/bjsm.33.1.27

Changes in haematological parameters and iron metabolism associated with a 1600 kilometre ultramarathon

K E Fallon, G Sivyer, K Sivyer, A Dare
PMCID: PMC1756141  PMID: 10027054

Abstract

OBJECTIVE: To investigate haematological variations and iron related changes in the serum of participants in a 1600 kilometre ultramarathon run. PARTICIPANTS: Seven male and two female participants in a 1600 km foot race. METHODS: Blood samples were obtained from the participants before, after four and 11 days of running, and at the end of the event. Samples were analysed by standard methods for haemoglobin, packed cell volume, total red cell count, mean red cell volume, mean red cell haemoglobin, total white cell count and differential, platelets, reticulocytes, iron, ferritin, total iron binding capacity, percentage transferrin saturation, haptoglobin, and bilirubin and corrected for changes in plasma volume. RESULTS: The following variables decreased during the event (p < 0.05): haemoglobin, packed cell volume, mean red cell volume, percentage lymphocytes, percentage monocytes, serum iron, total iron binding capacity, and percentage transferrin saturation. Increases (p < 0.05) were found in plasma volume, total red cell count (day 4 only), total white cell count, percentage and absolute numbers of neutrophils and reticulocytes, absolute numbers of lymphocytes and monocytes (day 4 only), absolute numbers of eosinophils (day 11 and race end), absolute numbers of basophils (race end only), platelets, ferritin, haptoglobin, and bilirubin (day 4 only). CONCLUSION: Ultramarathon running is associated with a wide range of changes in haematological parameters, many of which are related to the normal acute phase response to injury. These should not be confused with indicators of disease. 




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Selected References

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  1. Clarkson D. R., Moore E. M. Reticulocyte size in nutritional anemias. Blood. 1976 Nov;48(5):669–677. [PubMed] [Google Scholar]
  2. Davidson R. J., Robertson J. D., Galea G., Maughan R. J. Hematological changes associated with marathon running. Int J Sports Med. 1987 Feb;8(1):19–25. doi: 10.1055/s-2008-1025634. [DOI] [PubMed] [Google Scholar]
  3. Deitrick R. W. Intravascular haemolysis in the recreational runner. Br J Sports Med. 1991 Dec;25(4):183–187. doi: 10.1136/bjsm.25.4.183. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Dickson D. N., Wilkinson R. L., Noakes T. D. Effects of ultra-marathon training and racing on hematologic parameters and serum ferritin levels in well-trained athletes. Int J Sports Med. 1982 May;3(2):111–117. doi: 10.1055/s-2008-1026073. [DOI] [PubMed] [Google Scholar]
  5. Dill D. B., Costill D. L. Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. J Appl Physiol. 1974 Aug;37(2):247–248. doi: 10.1152/jappl.1974.37.2.247. [DOI] [PubMed] [Google Scholar]
  6. Dressendorfer R. H., Wade C. E., Amsterdam E. A. Development of of pseudoanemia in marathon runners during a 20-day road race. JAMA. 1981 Sep 11;246(11):1215–1218. [PubMed] [Google Scholar]
  7. Fellmann N., Bedu M., Giry J., Pharmakis-Amadieu M., Bezou M. J., Barlet J. P., Coudert J. Hormonal, fluid, and electrolyte changes during a 72-h recovery from a 24-h endurance run. Int J Sports Med. 1989 Dec;10(6):406–412. doi: 10.1055/s-2007-1024934. [DOI] [PubMed] [Google Scholar]
  8. Fellmann N., Sagnol M., Bedu M., Falgairette G., Van Praagh E., Gaillard G., Jouanel P., Coudert J. Enzymatic and hormonal responses following a 24 h endurance run and a 10 h triathlon race. Eur J Appl Physiol Occup Physiol. 1988;57(5):545–553. doi: 10.1007/BF00418460. [DOI] [PubMed] [Google Scholar]
  9. Jupe D. The acute phase response and laboratory testing. Aust Fam Physician. 1996 Mar;25(3):324–329. [PubMed] [Google Scholar]
  10. Lehmann M., Huonker M., Dimeo F., Heinz N., Gastmann U., Treis N., Steinacker J. M., Keul J., Kajewski R., Häussinger D. Serum amino acid concentrations in nine athletes before and after the 1993 Colmar ultra triathlon. Int J Sports Med. 1995 Apr;16(3):155–159. doi: 10.1055/s-2007-972984. [DOI] [PubMed] [Google Scholar]
  11. Nagel D., Seiler D., Franz H. Biochemical, hematological and endocrinological parameters during repeated intense short-term running in comparison to ultra-long-distance running. Int J Sports Med. 1992 May;13(4):337–343. doi: 10.1055/s-2007-1021277. [DOI] [PubMed] [Google Scholar]
  12. Noakes T. D., Carter J. W. Biochemical parameters in athletes before and after having run 160 kilometres. S Afr Med J. 1976 Sep 18;50(40):1562–1566. [PubMed] [Google Scholar]
  13. Osterud B., Olsen J. O., Wilsgård L. Effect of strenuous exercise on blood monocytes and their relation to coagulation. Med Sci Sports Exerc. 1989 Aug;21(4):374–378. [PubMed] [Google Scholar]
  14. Pyne D. B. Regulation of neutrophil function during exercise. Sports Med. 1994 Apr;17(4):245–258. doi: 10.2165/00007256-199417040-00005. [DOI] [PubMed] [Google Scholar]
  15. Rama R., Ibáez J., Riera M., Prats M. T., Pagés T., Palacios L. Hematological, electrolyte, and biochemical alterations after a 100-km run. Can J Appl Physiol. 1994 Dec;19(4):411–420. doi: 10.1139/h94-033. [DOI] [PubMed] [Google Scholar]
  16. Seiler D., Nagel D., Franz H., Hellstern P., Leitzmann C., Jung K. Effects of long-distance running on iron metabolism and hematological parameters. Int J Sports Med. 1989 Oct;10(5):357–362. doi: 10.1055/s-2007-1024928. [DOI] [PubMed] [Google Scholar]
  17. Smith J. A. Exercise, training and red blood cell turnover. Sports Med. 1995 Jan;19(1):9–31. doi: 10.2165/00007256-199519010-00002. [DOI] [PubMed] [Google Scholar]
  18. Stäubli M., Roessler B. The mean red cell volume in long distance runners. Eur J Appl Physiol Occup Physiol. 1986;55(1):49–53. doi: 10.1007/BF00422892. [DOI] [PubMed] [Google Scholar]
  19. Taylor C., Rogers G., Goodman C., Baynes R. D., Bothwell T. H., Bezwoda W. R., Kramer F., Hattingh J. Hematologic, iron-related, and acute-phase protein responses to sustained strenuous exercise. J Appl Physiol (1985) 1987 Feb;62(2):464–469. doi: 10.1152/jappl.1987.62.2.464. [DOI] [PubMed] [Google Scholar]
  20. Witte D. L. Can serum ferritin be effectively interpreted in the presence of the acute-phase response? Clin Chem. 1991 Apr;37(4):484–485. [PubMed] [Google Scholar]

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