Abstract
This study shows that Entamoeba histolytica binds hyaluronic acid. The binding molecule was identified as an 80-kDa membrane protein and was recognized by anti-CD44 monoclonal antibodies. These data indicate that a CD44 cross-reacting adherence molecule is expressed on E. histolytica.
Full Text
The Full Text of this article is available as a PDF (628.7 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Arroyo R., Orozco E. Localization and identification of an Entamoeba histolytica adhesin. Mol Biochem Parasitol. 1987 Mar;23(2):151–158. doi: 10.1016/0166-6851(87)90150-2. [DOI] [PubMed] [Google Scholar]
- Chadee K., Petri W. A., Jr, Innes D. J., Ravdin J. I. Rat and human colonic mucins bind to and inhibit adherence lectin of Entamoeba histolytica. J Clin Invest. 1987 Nov;80(5):1245–1254. doi: 10.1172/JCI113199. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Culty M., Miyake K., Kincade P. W., Sikorski E., Butcher E. C., Underhill C., Silorski E. The hyaluronate receptor is a member of the CD44 (H-CAM) family of cell surface glycoproteins. J Cell Biol. 1990 Dec;111(6 Pt 1):2765–2774. doi: 10.1083/jcb.111.6.2765. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lacy B. E., Underhill C. B. The hyaluronate receptor is associated with actin filaments. J Cell Biol. 1987 Sep;105(3):1395–1404. doi: 10.1083/jcb.105.3.1395. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Leroy A., Mareel M., De Bruyne G., Bailey G., Nelis H. Metastasis of Entamoeba histolytica compared to colon cancer: one more step in invasion. Invasion Metastasis. 1994;14(1-6):177–191. [PubMed] [Google Scholar]
- Li E., Stenson W. F., Kunz-Jenkins C., Swanson P. E., Duncan R., Stanley S. L., Jr Entamoeba histolytica interactions with polarized human intestinal Caco-2 epithelial cells. Infect Immun. 1994 Nov;62(11):5112–5119. doi: 10.1128/iai.62.11.5112-5119.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Love S. H., Shannon B. T., Myrvik Q. N., Lynn W. S. Characterization of macrophage agglutinating factor as a hyaluronic acid-protein complex. J Reticuloendothel Soc. 1979 Mar;25(3):269–282. [PubMed] [Google Scholar]
- Ohya T., Kaneko Y. Novel hyaluronidase from streptomyces. Biochim Biophys Acta. 1970 Mar 18;198(3):607–609. doi: 10.1016/0005-2744(70)90139-7. [DOI] [PubMed] [Google Scholar]
- Pessac B., Defendi V. Cell aggregation: role of acid mucopolysaccharides. Science. 1972 Feb 25;175(4024):898–900. doi: 10.1126/science.175.4024.898. [DOI] [PubMed] [Google Scholar]
- Ravdin J. I. Amebiasis. Clin Infect Dis. 1995 Jun;20(6):1453–1466. doi: 10.1093/clinids/20.6.1453. [DOI] [PubMed] [Google Scholar]
- Rigothier M. C., Coconnier M. H., Servin A. L., Gayral P. A new in vitro model of Entamoeba histolytica adhesion, using the human colon carcinoma cell line Caco-2: scanning electron microscopic study. Infect Immun. 1991 Nov;59(11):4142–4146. doi: 10.1128/iai.59.11.4142-4146.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rosales-Encina J. L., Meza I., López-De-León A., Talamás-Rohana P., Rojkind M. Isolation of a 220-kilodalton protein with lectin properties from a virulent strain of Entamoeba histolytica. J Infect Dis. 1987 Nov;156(5):790–797. doi: 10.1093/infdis/156.5.790. [DOI] [PubMed] [Google Scholar]
- Stamenkovic I., Amiot M., Pesando J. M., Seed B. A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family. Cell. 1989 Mar 24;56(6):1057–1062. doi: 10.1016/0092-8674(89)90638-7. [DOI] [PubMed] [Google Scholar]
- Stamenkovic I., Aruffo A. Hyaluronic acid receptors. Methods Enzymol. 1994;245:195–216. doi: 10.1016/0076-6879(94)45012-9. [DOI] [PubMed] [Google Scholar]
- Talamás-Rohana P., Hernández V. I., Rosales-Encina J. L. A beta 1 integrin-like molecule in Entamoeba histolytica. Trans R Soc Trop Med Hyg. 1994 Sep-Oct;88(5):596–599. doi: 10.1016/0035-9203(94)90179-1. [DOI] [PubMed] [Google Scholar]
- Talamás-Rohana P., Meza I. Interaction between pathogenic amebas and fibronectin: substrate degradation and changes in cytoskeleton organization. J Cell Biol. 1988 May;106(5):1787–1794. doi: 10.1083/jcb.106.5.1787. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Walsh J. A. Problems in recognition and diagnosis of amebiasis: estimation of the global magnitude of morbidity and mortality. Rev Infect Dis. 1986 Mar-Apr;8(2):228–238. doi: 10.1093/clinids/8.2.228. [DOI] [PubMed] [Google Scholar]