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. 1997 Oct;65(10):4334–4336. doi: 10.1128/iai.65.10.4334-4336.1997

Ablation of interleukin-12 exacerbates Lyme arthritis in SCID mice.

J Anguita 1, S Samanta 1, S W Barthold 1, E Fikrig 1
PMCID: PMC175621  PMID: 9317045

Abstract

The administration of interleukin-12 (IL-12) antibodies to Borrelia burgdorferi-infected C3H/HeN-scid mice increased the severity of acute Lyme arthritis. These results contrasted with the reduction of Lyme arthritis by IL-12 antibodies in immunocompetent animals. These data suggest that downregulation of innate immunity in SCID mice in the absence of B- and T-cell responses leads to an exacerbation of joint inflammation.

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Selected References

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