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. 2002 Nov;19(6):494–498. doi: 10.1136/emj.19.6.494

Fluid resuscitation in prehospital trauma care: a consensus view

M Revell 1, K Porter 1, I Greaves 1
PMCID: PMC1756310  PMID: 12421770

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Selected References

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  1. Alderson P., Schierhout G., Roberts I., Bunn F. Colloids versus crystalloids for fluid resuscitation in critically ill patients. Cochrane Database Syst Rev. 2000;(2):CD000567–CD000567. doi: 10.1002/14651858.CD000567. [DOI] [PubMed] [Google Scholar]
  2. Bickell W. H., Bruttig S. P., Millnamow G. A., O'Benar J., Wade C. E. The detrimental effects of intravenous crystalloid after aortotomy in swine. Surgery. 1991 Sep;110(3):529–536. [PubMed] [Google Scholar]
  3. Bickell W. H., Bruttig S. P., Millnamow G. A., O'Benar J., Wade C. E. Use of hypertonic saline/dextran versus lactated Ringer's solution as a resuscitation fluid after uncontrolled aortic hemorrhage in anesthetized swine. Ann Emerg Med. 1992 Sep;21(9):1077–1085. doi: 10.1016/s0196-0644(05)80648-1. [DOI] [PubMed] [Google Scholar]
  4. Bickell W. H., Wall M. J., Jr, Pepe P. E., Martin R. R., Ginger V. F., Allen M. K., Mattox K. L. Immediate versus delayed fluid resuscitation for hypotensive patients with penetrating torso injuries. N Engl J Med. 1994 Oct 27;331(17):1105–1109. doi: 10.1056/NEJM199410273311701. [DOI] [PubMed] [Google Scholar]
  5. Boldt J., Heesen M., Padberg W., Martin K., Hempelmann G. The influence of volume therapy and pentoxifylline infusion on circulating adhesion molecules in trauma patients. Anaesthesia. 1996 Jun;51(6):529–535. doi: 10.1111/j.1365-2044.1996.tb12557.x. [DOI] [PubMed] [Google Scholar]
  6. Bunn F., Alderson P., Hawkins V. Colloid solutions for fluid resuscitation. Cochrane Database Syst Rev. 2000;(2):CD001319–CD001319. doi: 10.1002/14651858.CD001319. [DOI] [PubMed] [Google Scholar]
  7. Capone A., Safar P., Stezoski S. W., Peitzman A., Tisherman S. Uncontrolled hemorrhagic shock outcome model in rats. Resuscitation. 1995 Apr;29(2):143–152. doi: 10.1016/0300-9572(95)00829-i. [DOI] [PubMed] [Google Scholar]
  8. Choi P. T., Yip G., Quinonez L. G., Cook D. J. Crystalloids vs. colloids in fluid resuscitation: a systematic review. Crit Care Med. 1999 Jan;27(1):200–210. doi: 10.1097/00003246-199901000-00053. [DOI] [PubMed] [Google Scholar]
  9. Chudnofsky C. R., Dronen S. C., Syverud S. A., Hedges J. R., Zink B. J. Early versus late fluid resuscitation: lack of effect in porcine hemorrhagic shock. Ann Emerg Med. 1989 Feb;18(2):122–126. doi: 10.1016/s0196-0644(89)80099-x. [DOI] [PubMed] [Google Scholar]
  10. Cohn S. M. Is blood obsolete? J Trauma. 1997 Apr;42(4):730–732. doi: 10.1097/00005373-199704000-00025. [DOI] [PubMed] [Google Scholar]
  11. Craig R. L., Poole G. V. Resuscitation in uncontrolled hemorrhage. Am Surg. 1994 Jan;60(1):59–62. [PubMed] [Google Scholar]
  12. Deakin C. D., Low J. L. Accuracy of the advanced trauma life support guidelines for predicting systolic blood pressure using carotid, femoral, and radial pulses: observational study. BMJ. 2000 Sep 16;321(7262):673–674. doi: 10.1136/bmj.321.7262.673. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Demetriades D., Chan L., Cornwell E., Belzberg H., Berne T. V., Asensio J., Chan D., Eckstein M., Alo K. Paramedic vs private transportation of trauma patients. Effect on outcome. Arch Surg. 1996 Feb;131(2):133–138. doi: 10.1001/archsurg.1996.01430140023007. [DOI] [PubMed] [Google Scholar]
  14. Dries D. J. Hypotensive resuscitation. Shock. 1996 Nov;6(5):311–316. doi: 10.1097/00024382-199611000-00001. [DOI] [PubMed] [Google Scholar]
  15. Ferrara A., MacArthur J. D., Wright H. K., Modlin I. M., McMillen M. A. Hypothermia and acidosis worsen coagulopathy in the patient requiring massive transfusion. Am J Surg. 1990 Nov;160(5):515–518. doi: 10.1016/s0002-9610(05)81018-9. [DOI] [PubMed] [Google Scholar]
  16. Franz A., Bräunlich P., Gamsjäger T., Felfernig M., Gustorff B., Kozek-Langenecker S. A. The effects of hydroxyethyl starches of varying molecular weights on platelet function. Anesth Analg. 2001 Jun;92(6):1402–1407. doi: 10.1097/00000539-200106000-00008. [DOI] [PubMed] [Google Scholar]
  17. Jacobs L. M., Sinclair A., Beiser A., D'Agostino R. B. Prehospital advanced life support: benefits in trauma. J Trauma. 1984 Jan;24(1):8–13. doi: 10.1097/00005373-198401000-00002. [DOI] [PubMed] [Google Scholar]
  18. Johnson G. S., Guly H. R. The effect of pre-hospital administration of intravenous nalbuphine on on-scene times. J Accid Emerg Med. 1995 Mar;12(1):20–22. doi: 10.1136/emj.12.1.20. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Kim S. H., Stezoski S. W., Safar P., Capone A., Tisherman S. Hypothermia and minimal fluid resuscitation increase survival after uncontrolled hemorrhagic shock in rats. J Trauma. 1997 Feb;42(2):213–222. doi: 10.1097/00005373-199702000-00006. [DOI] [PubMed] [Google Scholar]
  20. Krausz M. M., Bar-Ziv M., Rabinovici R., Gross D. "Scoop and run" or stabilize hemorrhagic shock with normal saline or small-volume hypertonic saline? J Trauma. 1992 Jul;33(1):6–10. doi: 10.1097/00005373-199207000-00002. [DOI] [PubMed] [Google Scholar]
  21. Krausz M. M., Landau E. H., Klin B., Gross D. Hypertonic saline treatment of uncontrolled hemorrhagic shock at different periods from bleeding. Arch Surg. 1992 Jan;127(1):93–96. doi: 10.1001/archsurg.1992.01420010107017. [DOI] [PubMed] [Google Scholar]
  22. Makin A., Plenderleith L. Fluid resuscitation with colloid or crystalloid solutions. One conclusion could be that hypertonic saline is better than colloids in trauma. BMJ. 1998 Jul 25;317(7153):277–279. [PubMed] [Google Scholar]
  23. Miller J. D., Becker D. P. Secondary insults to the injured brain. J R Coll Surg Edinb. 1982 Sep;27(5):292–298. [PubMed] [Google Scholar]
  24. Nicholl J., Hughes S., Dixon S., Turner J., Yates D. The costs and benefits of paramedic skills in pre-hospital trauma care. Health Technol Assess. 1998;2(17):i-iv, 1-72. [PubMed] [Google Scholar]
  25. O'Gorman M., Trabulsy P., Pilcher D. B. Zero-time prehospital i.v. J Trauma. 1989 Jan;29(1):84–86. [PubMed] [Google Scholar]
  26. Pepe P. E., Wyatt C. H., Bickell W. H., Bailey M. L., Mattox K. L. The relationship between total prehospital time and outcome in hypotensive victims of penetrating injuries. Ann Emerg Med. 1987 Mar;16(3):293–297. doi: 10.1016/s0196-0644(87)80174-9. [DOI] [PubMed] [Google Scholar]
  27. Pons P. T., Moore E. E., Cusick J. M., Brunko M., Antuna B., Owens L. Prehospital venous access in an urban paramedic system--a prospective on-scene analysis. J Trauma. 1988 Oct;28(10):1460–1463. doi: 10.1097/00005373-198810000-00009. [DOI] [PubMed] [Google Scholar]
  28. Powar M., Nguyen-Van-Tam J., Pearson J., Dove A. Hidden impact of paramedic interventions. J Accid Emerg Med. 1996 Nov;13(6):383–385. doi: 10.1136/emj.13.6.383. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Rabinovici R., Krausz M. M., Feuerstein G. Control of bleeding is essential for a successful treatment of hemorrhagic shock with 7.5 per cent sodium chloride solution. Surg Gynecol Obstet. 1991 Aug;173(2):98–106. [PubMed] [Google Scholar]
  30. Riddez L., Johnson L., Hahn R. G. Central and regional hemodynamics during crystalloid fluid therapy after uncontrolled intra-abdominal bleeding. J Trauma. 1998 Mar;44(3):433–439. doi: 10.1097/00005373-199803000-00001. [DOI] [PubMed] [Google Scholar]
  31. Russell I. S. Accuracy of ATLS guidelines for predicting systolic blood pressure. Authors' core assertion was wrong. BMJ. 2001 Mar 3;322(7285):552–553. [PMC free article] [PubMed] [Google Scholar]
  32. Russell I. S. Accuracy of ATLS guidelines for predicting systolic blood pressure. Authors' core assertion was wrong. BMJ. 2001 Mar 3;322(7285):552–553. [PMC free article] [PubMed] [Google Scholar]
  33. Sampalis J. S., Tamim H., Denis R., Boukas S., Ruest S. A., Nikolis A., Lavoie A., Fleiszer D., Brown R., Mulder D. Ineffectiveness of on-site intravenous lines: is prehospital time the culprit? J Trauma. 1997 Oct;43(4):608–617. doi: 10.1097/00005373-199710000-00008. [DOI] [PubMed] [Google Scholar]
  34. Schierhout G., Roberts I. Fluid resuscitation with colloid or crystalloid solutions in critically ill patients: a systematic review of randomised trials. BMJ. 1998 Mar 28;316(7136):961–964. doi: 10.1136/bmj.316.7136.961. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Shirani K. Z., Vaughan G. M., Mason A. D., Jr, Pruitt B. A., Jr Update on current therapeutic approaches in burns. Shock. 1996 Jan;5(1):4–16. [PubMed] [Google Scholar]
  36. Sindlinger J. F., Soucy D. M., Greene S. P., Barber A. E., Illner H., Shires G. T. The effects of isotonic saline volume resuscitation in uncontrolled hemorrhage. Surg Gynecol Obstet. 1993 Dec;177(6):545–550. [PubMed] [Google Scholar]
  37. Slovis C. M., Herr E. W., Londorf D., Little T. D., Alexander B. R., Guthmann R. J. Success rates for initiation of intravenous therapy en route by prehospital care providers. Am J Emerg Med. 1990 Jul;8(4):305–307. doi: 10.1016/0735-6757(90)90080-j. [DOI] [PubMed] [Google Scholar]
  38. Soucy D. M., Sindlinger J. F., Greene S. P., Barber A. E., Illner H. P., Shires G. T. Isotonic saline resuscitation in uncontrolled hemorrhage under various anesthetic conditions. Ann Surg. 1995 Jul;222(1):87–93. doi: 10.1097/00000658-199507000-00014. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. Soucy D. M., Sindlinger J. F., Greene S. P., Barber A., Illner H., Shires G. T. Effects of anesthesia on a model of uncontrolled hemorrhage in rats. Crit Care Med. 1995 Sep;23(9):1528–1532. doi: 10.1097/00003246-199509000-00013. [DOI] [PubMed] [Google Scholar]
  40. Stern S. A., Dronen S. C., Birrer P., Wang X. Effect of blood pressure on hemorrhage volume and survival in a near-fatal hemorrhage model incorporating a vascular injury. Ann Emerg Med. 1993 Feb;22(2):155–163. doi: 10.1016/s0196-0644(05)80195-7. [DOI] [PubMed] [Google Scholar]
  41. Stern S. A., Dronen S. C., Wang X. Multiple resuscitation regimens in a near-fatal porcine aortic injury hemorrhage model. Acad Emerg Med. 1995 Feb;2(2):89–97. doi: 10.1111/j.1553-2712.1995.tb03167.x. [DOI] [PubMed] [Google Scholar]
  42. Traverso L. W., Hollenbach S. J., Bolin R. B., Langford M. J., DeGuzman L. R. Fluid resuscitation after an otherwise fatal hemorrhage: II. Colloid solutions. J Trauma. 1986 Feb;26(2):176–182. doi: 10.1097/00005373-198602000-00015. [DOI] [PubMed] [Google Scholar]
  43. Traverso L. W., Lee W. P., Langford M. J. Fluid resuscitation after an otherwise fatal hemorrhage: I. Crystalloid solutions. J Trauma. 1986 Feb;26(2):168–175. doi: 10.1097/00005373-198602000-00014. [DOI] [PubMed] [Google Scholar]
  44. Traverso L. W., Medina F., Bolin R. B. The buffering capacity of crystalloid and colloid resuscitation solutions. Resuscitation. 1985 Mar;12(4):265–270. doi: 10.1016/0300-9572(85)90007-3. [DOI] [PubMed] [Google Scholar]
  45. Veech R. L. Immediate versus delayed fluid resuscitation in patients with trauma. N Engl J Med. 1995 Mar 9;332(10):681–683. [PubMed] [Google Scholar]
  46. Wade C. E., Grady J. J., Kramer G. C., Younes R. N., Gehlsen K., Holcroft J. W. Individual patient cohort analysis of the efficacy of hypertonic saline/dextran in patients with traumatic brain injury and hypotension. J Trauma. 1997 May;42(5 Suppl):S61–S65. doi: 10.1097/00005373-199705001-00011. [DOI] [PubMed] [Google Scholar]
  47. Watts D. D., Trask A., Soeken K., Perdue P., Dols S., Kaufmann C. Hypothermic coagulopathy in trauma: effect of varying levels of hypothermia on enzyme speed, platelet function, and fibrinolytic activity. J Trauma. 1998 May;44(5):846–854. doi: 10.1097/00005373-199805000-00017. [DOI] [PubMed] [Google Scholar]
  48. Wears R. L., Winton C. N. Load and go versus stay and play: analysis of prehospital i.v. fluid therapy by computer simulation. Ann Emerg Med. 1990 Feb;19(2):163–168. doi: 10.1016/s0196-0644(05)81802-5. [DOI] [PubMed] [Google Scholar]
  49. Williams E. L., Hildebrand K. L., McCormick S. A., Bedel M. J. The effect of intravenous lactated Ringer's solution versus 0.9% sodium chloride solution on serum osmolality in human volunteers. Anesth Analg. 1999 May;88(5):999–1003. doi: 10.1097/00000539-199905000-00006. [DOI] [PubMed] [Google Scholar]
  50. Wilmink A. B., Samra G. S., Watson L. M., Wilson A. W. Vehicle entrapment rescue and pre-hospital trauma care. Injury. 1996 Jan;27(1):21–25. doi: 10.1016/0020-1383(95)00162-x. [DOI] [PubMed] [Google Scholar]

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