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Journal of Epidemiology and Community Health logoLink to Journal of Epidemiology and Community Health
. 1999 Jan;53(1):20–23. doi: 10.1136/jech.53.1.20

Study of environmental, social, and paternal factors in preterm delivery using sibs and half sibs. A population-based study in Denmark

O Basso, J Olsen, K Christensen
PMCID: PMC1756768  PMID: 10326048

Abstract

OBJECTIVE: The aim of this study was to evaluate the influence on preterm delivery of changes in putative genetic and environmental risk factors between two consecutive births. Low social status is a suspected risk indicator of preterm delivery, but the impact of social mobility has not been studied before. PARTICIPANTS: The study uses national cohorts in which women act as their own controls. Subjects were identified by means of registries: 10,455 women who gave birth to a preterm child and had a subsequent live birth between 1980 and 1992 and 9849 women who gave birth to a child after 37 completed weeks of gestation and had a subsequent live born child in the same time period formed the cohorts. METHODS: The risk of having a premature infant in the subsequent pregnancy was analysed in each cohort as a function of changes in male partner, residency, occupation, and social status between the two pregnancies. RESULTS: There was a strong tendency to repeat a preterm delivery (18% v 6% in the general population). Social decline was associated with a moderate increase in the recurrence risk (OR: 1.22; 95% CI: 1.02, 1.47). In the reference cohort the risk of preterm delivery associated with changing from a rural to an urban municipality was 2.03 (95% CI: 1.14, 3.64). CONCLUSIONS: Social decline and moving to an urban municipality may be associated with preterm delivery.

 

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Selected References

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  1. Bakketeig L. S., Hoffman H. J., Harley E. E. The tendency to repeat gestational age and birth weight in successive births. Am J Obstet Gynecol. 1979 Dec 15;135(8):1086–1103. doi: 10.1016/0002-9378(79)90742-7. [DOI] [PubMed] [Google Scholar]
  2. Basso O., Olsen J., Christensen K. Risk of preterm delivery, low birthweight and growth retardation following spontaneous abortion: a registry-based study in Denmark. Int J Epidemiol. 1998 Aug;27(4):642–646. doi: 10.1093/ije/27.4.642. [DOI] [PubMed] [Google Scholar]
  3. Basso O., Olsen J., Johansen A. M., Christensen K. Change in social status and risk of low birth weight in Denmark: population based cohort study. BMJ. 1997 Dec 6;315(7121):1498–1502. doi: 10.1136/bmj.315.7121.1498. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Berkowitz G. S., Papiernik E. Epidemiology of preterm birth. Epidemiol Rev. 1993;15(2):414–443. doi: 10.1093/oxfordjournals.epirev.a036128. [DOI] [PubMed] [Google Scholar]
  5. Carr-Hill R. A., Hall M. H. The repetition of spontaneous preterm labour. Br J Obstet Gynaecol. 1985 Sep;92(9):921–928. doi: 10.1111/j.1471-0528.1985.tb03071.x. [DOI] [PubMed] [Google Scholar]
  6. Christiansen O. B. Epidemiological, immunogenetic and immunotherapeutic aspects of unexplained recurrent miscarriage. Dan Med Bull. 1997 Sep;44(4):396–424. [PubMed] [Google Scholar]
  7. Ekwo E. E., Gosselink C. A., Woolson R., Moawad A. Risks for premature rupture of amniotic membranes. Int J Epidemiol. 1993 Jun;22(3):495–503. doi: 10.1093/ije/22.3.495. [DOI] [PubMed] [Google Scholar]
  8. Goldenberg R. L., Iams J. D., Mercer B. M., Meis P. J., Moawad A. H., Copper R. L., Das A., Thom E., Johnson F., McNellis D. The preterm prediction study: the value of new vs standard risk factors in predicting early and all spontaneous preterm births. NICHD MFMU Network. Am J Public Health. 1998 Feb;88(2):233–238. doi: 10.2105/ajph.88.2.233. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Hack M., Merkatz I. R. Preterm delivery and low birth weight--a dire legacy. N Engl J Med. 1995 Dec 28;333(26):1772–1774. doi: 10.1056/NEJM199512283332611. [DOI] [PubMed] [Google Scholar]
  10. Keirse M. J., Rush R. W., Anderson A. B., Turnbull A. C. Risk of pre-term delivery in patients with previous pre-term delivery and/or abortion. Br J Obstet Gynaecol. 1978 Feb;85(2):81–85. doi: 10.1111/j.1471-0528.1978.tb10457.x. [DOI] [PubMed] [Google Scholar]
  11. Knudsen L. B. The Danish Fertility Database. Dan Med Bull. 1998 Apr;45(2):221–225. [PubMed] [Google Scholar]
  12. Kramer M. S. Intrauterine growth and gestational duration determinants. Pediatrics. 1987 Oct;80(4):502–511. [PubMed] [Google Scholar]
  13. Lang J. M., Lieberman E., Cohen A. A comparison of risk factors for preterm labor and term small-for-gestational-age birth. Epidemiology. 1996 Jul;7(4):369–376. doi: 10.1097/00001648-199607000-00006. [DOI] [PubMed] [Google Scholar]
  14. Lumley J. How important is social class a factor in preterm birth? Lancet. 1997 Apr 12;349(9058):1040–1041. doi: 10.1016/S0140-6736(05)62287-8. [DOI] [PubMed] [Google Scholar]
  15. Magnus P., Bakketeig L. S., Skjaerven R. Correlations of birth weight and gestational age across generations. Ann Hum Biol. 1993 May-Jun;20(3):231–238. doi: 10.1080/03014469300002662. [DOI] [PubMed] [Google Scholar]
  16. Main D. M. The epidemiology of preterm birth. Clin Obstet Gynecol. 1988 Sep;31(3):521–532. doi: 10.1097/00003081-198809000-00004. [DOI] [PubMed] [Google Scholar]
  17. Meis P. J., Michielutte R., Peters T. J., Wells H. B., Sands R. E., Coles E. C., Johns K. A. Factors associated with preterm birth in Cardiff, Wales. II. Indicated and spontaneous preterm birth. Am J Obstet Gynecol. 1995 Aug;173(2):597–602. doi: 10.1016/0002-9378(95)90288-0. [DOI] [PubMed] [Google Scholar]
  18. Mercer B. M., Goldenberg R. L., Das A., Moawad A. H., Iams J. D., Meis P. J., Copper R. L., Johnson F., Thom E., McNellis D. The preterm prediction study: a clinical risk assessment system. Am J Obstet Gynecol. 1996 Jun;174(6):1885–1895. doi: 10.1016/s0002-9378(96)70225-9. [DOI] [PubMed] [Google Scholar]
  19. Olsen J., Schmidt M. M., Christensen K. Evaluation of nature-nurture impact on reproductive health using half-siblings. Epidemiology. 1997 Jan;8(1):6–11. doi: 10.1097/00001648-199701000-00001. [DOI] [PubMed] [Google Scholar]
  20. Parker J. D., Schoendorf K. C., Kiely J. L. Associations between measures of socioeconomic status and low birth weight, small for gestational age, and premature delivery in the United States. Ann Epidemiol. 1994 Jul;4(4):271–278. doi: 10.1016/1047-2797(94)90082-5. [DOI] [PubMed] [Google Scholar]
  21. Pickering R. M., Forbes J. F. Risks of preterm delivery and small-for-gestational age infants following abortion: a population study. Br J Obstet Gynaecol. 1985 Nov;92(11):1106–1112. doi: 10.1111/j.1471-0528.1985.tb03020.x. [DOI] [PubMed] [Google Scholar]
  22. Romero R., Mazor M. Infection and preterm labor. Clin Obstet Gynecol. 1988 Sep;31(3):553–584. doi: 10.1097/00003081-198809000-00006. [DOI] [PubMed] [Google Scholar]
  23. Rothman K. J. Causes. Am J Epidemiol. 1976 Dec;104(6):587–592. doi: 10.1093/oxfordjournals.aje.a112335. [DOI] [PubMed] [Google Scholar]
  24. Savitz D. A., Blackmore C. A., Thorp J. M. Epidemiologic characteristics of preterm delivery: etiologic heterogeneity. Am J Obstet Gynecol. 1991 Feb;164(2):467–471. doi: 10.1016/s0002-9378(11)80001-3. [DOI] [PubMed] [Google Scholar]
  25. Stein A., Campbell E. A., Day A., McPherson K., Cooper P. J. Social adversity, low birth weight, and preterm delivery. Br Med J (Clin Res Ed) 1987 Aug 1;295(6593):291–293. doi: 10.1136/bmj.295.6593.291. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Verp M. S., Sibul M., Billstrand C., Bellen G., Hsu M., Ober C. Maternal-fetal histocompatibility in intrauterine growth retarded and normal weight babies. Am J Reprod Immunol. 1993 May;29(4):195–198. doi: 10.1111/j.1600-0897.1993.tb00586.x. [DOI] [PubMed] [Google Scholar]
  27. Wildschut H. I., Nas T., Golding J. Are sociodemographic factors predictive of preterm birth? A reappraisal of the 1958 British Perinatal Mortality Survey. Br J Obstet Gynaecol. 1997 Jan;104(1):57–63. doi: 10.1111/j.1471-0528.1997.tb10650.x. [DOI] [PubMed] [Google Scholar]

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