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Journal of Epidemiology and Community Health logoLink to Journal of Epidemiology and Community Health
. 1999 Aug;53(8):459–464. doi: 10.1136/jech.53.8.459

Longer pre-hospital delay in acute myocardial infarction in women because of longer doctor decision time

J Bouma, J Broer, J Bleeker, E van Sonderen, J Meyboom-de, M J DeJongste
PMCID: PMC1756944  PMID: 10562863

Abstract

STUDY OBJECTIVE: To measure the pre-hospital delay times in patients with proven acute myocardial infarction (AMI) and to identify possibilities for reduction of treatment delay. DESIGN: Descriptive three centre study. SETTING: One university teaching hospital and two regional hospitals in Groningen, the Netherlands. PATIENTS: 400 consecutive confirmed AMI patients, age below 75 years, admitted to coronary care departments. MAIN RESULTS: Mean age was 59 years and 78% of patients were men. Within two hours after onset of symptoms half of the patients with AMI arrived at the hospital. Patient, doctor, and ambulance delay times (median values) were 30, 38, and 35 minutes respectively. Calling the personal general practitioner (GP) or the locum tenens and whether or not the AMI occurred during a weekend or on a working day had no consequences for pre-hospital delay times. At night patients waited longer before calling a GP than in the daytime. There was a positive correlation between patient and doctor delay. Twenty two per cent of AMI patients waited two hours or more before calling a GP. Total pre-hospital delay times differed between men and women. Longer doctor delay in women (36 minutes for men and 52 minutes for women) was caused by displacement of specific symptoms, in particular in women. AMI patients who were alone during onset of symptoms showed higher patients delay (72 compared with 23 minutes). CONCLUSION: In hospital admitted patients younger than 75 years pre- hospital delay times are within acceptable limits. In some subgroups further reduction is attainable, for example in patient delay outside office hours and when patients are alone during onset of symptoms, in doctor delay in cases where women present with symptoms suggestive for AMI. Improvement of facilities for pre-hospital electrocardiographic diagnosis may facilitate decision making by GPs. Good opportunities for further reduction of treatment delay exist in shortening of hospital delay.

 

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Selected References

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  1. Bar F. W., Vermeer F., de Zwaan C., Ramentol M., Braat S., Simoons M. L., Hermens W. T., van der Laarse A., Verheugt F. W., Krauss X. H. Value of admission electrocardiogram in predicting outcome of thrombolytic therapy in acute myocardial infarction. A randomized trial conducted by The Netherlands Interuniversity Cardiology Institute. Am J Cardiol. 1987 Jan 1;59(1):6–13. doi: 10.1016/s0002-9149(87)80060-7. [DOI] [PubMed] [Google Scholar]
  2. Beunderman R. "Patient delay" en het herkennen van hartinfarctverschijnselen. Ned Tijdschr Geneeskd. 1976 Feb 28;120(9):374–378. [PubMed] [Google Scholar]
  3. Birkhead J. S. Time delays in provision of thrombolytic treatment in six district hospitals. Joint Audit Committee of the British Cardiac Society and a Cardiology Committee of Royal College of Physicians of London. BMJ. 1992 Aug 22;305(6851):445–448. doi: 10.1136/bmj.305.6851.445. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bleeker J. K., Simoons M. L., Erdman R. A., Leenders C. M., Kruyssen H. A., Lamers L. M., van der Does E. Patient and doctor delay in acute myocardial infarction: a study in Rotterdam, The Netherlands. Br J Gen Pract. 1995 Apr;45(393):181–184. [PMC free article] [PubMed] [Google Scholar]
  5. Boersma E., Maas A. C., Deckers J. W., Simoons M. L. Early thrombolytic treatment in acute myocardial infarction: reappraisal of the golden hour. Lancet. 1996 Sep 21;348(9030):771–775. doi: 10.1016/S0140-6736(96)02514-7. [DOI] [PubMed] [Google Scholar]
  6. Boersma E., Maas A. C., Deckers J. W., Simoons M. L. Early thrombolytic treatment in acute myocardial infarction: reappraisal of the golden hour. Lancet. 1996 Sep 21;348(9030):771–775. doi: 10.1016/S0140-6736(96)02514-7. [DOI] [PubMed] [Google Scholar]
  7. Boisjolie C. R., Sharkey S. W., Cannon C. P., Brunette D., Haugland J. M., Thatcher J. L., Henry T. D. Impact of a thrombolysis research trial on time to treatment for acute myocardial infarction in the emergency department. Am J Cardiol. 1995 Aug 15;76(5):396–398. doi: 10.1016/s0002-9149(99)80108-8. [DOI] [PubMed] [Google Scholar]
  8. Bouten M. J., Simoons M. L., Hartman J. A., van Miltenburg A. J., van der Does E., Pool J. Prehospital thrombolysis with alteplase (rt-PA) in acute myocardial infarction. Eur Heart J. 1992 Jul;13(7):925–931. doi: 10.1093/oxfordjournals.eurheartj.a060294. [DOI] [PubMed] [Google Scholar]
  9. Brügemann J., van der Meer J., de Graeff P. A., Takens L. H., Lie K. I. Logistical problems in prehospital thrombolysis. Eur Heart J. 1992 Jun;13(6):787–788. doi: 10.1093/oxfordjournals.eurheartj.a060257. [DOI] [PubMed] [Google Scholar]
  10. Hunink M. G., Goldman L., Tosteson A. N., Mittleman M. A., Goldman P. A., Williams L. W., Tsevat J., Weinstein M. C. The recent decline in mortality from coronary heart disease, 1980-1990. The effect of secular trends in risk factors and treatment. JAMA. 1997 Feb 19;277(7):535–542. [PubMed] [Google Scholar]
  11. Kitler M. E. Coronary disease: are there gender differences? Eur Heart J. 1994 Mar;15(3):409–417. doi: 10.1093/oxfordjournals.eurheartj.a060515. [DOI] [PubMed] [Google Scholar]
  12. Lerner D. J., Kannel W. B. Patterns of coronary heart disease morbidity and mortality in the sexes: a 26-year follow-up of the Framingham population. Am Heart J. 1986 Feb;111(2):383–390. doi: 10.1016/0002-8703(86)90155-9. [DOI] [PubMed] [Google Scholar]
  13. Maynard C., Weaver W. D., Lambrew C., Bowlby L. J., Rogers W. J., Rubison R. M. Factors influencing the time to administration of thrombolytic therapy with recombinant tissue plasminogen activator (data from the National Registry of Myocardial Infarction). Participants in the National Registry of Myocardial Infarction. Am J Cardiol. 1995 Sep 15;76(8):548–552. doi: 10.1016/s0002-9149(99)80152-0. [DOI] [PubMed] [Google Scholar]
  14. Newby L. K., Rutsch W. R., Califf R. M., Simoons M. L., Aylward P. E., Armstrong P. W., Woodlief L. H., Lee K. L., Topol E. J., Van de Werf F. Time from symptom onset to treatment and outcomes after thrombolytic therapy. GUSTO-1 Investigators. J Am Coll Cardiol. 1996 Jun;27(7):1646–1655. doi: 10.1016/0735-1097(96)00053-8. [DOI] [PubMed] [Google Scholar]
  15. Rawles J. M., Haites N. E. Patient and general practitioner delays in acute myocardial infarction. Br Med J (Clin Res Ed) 1988 Mar 26;296(6626):882–884. doi: 10.1136/bmj.296.6626.882. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Rogers W. J., Bowlby L. J., Chandra N. C., French W. J., Gore J. M., Lambrew C. T., Rubison R. M., Tiefenbrunn A. J., Weaver W. D. Treatment of myocardial infarction in the United States (1990 to 1993). Observations from the National Registry of Myocardial Infarction. Circulation. 1994 Oct;90(4):2103–2114. doi: 10.1161/01.cir.90.4.2103. [DOI] [PubMed] [Google Scholar]
  17. Simon A. B., Feinleib M., Thompson H. K., Jr Components of delay in the pre-hospital phase of acute myocardial infarction. Am J Cardiol. 1972 Oct;30(5):476–482. doi: 10.1016/0002-9149(72)90037-9. [DOI] [PubMed] [Google Scholar]
  18. Simoons M. L., Serruys P. W., vd Brand M., Bär F., de Zwaan C., Res J., Verheugt F. W., Krauss X. H., Remme W. J., Vermeer F. Improved survival after early thrombolysis in acute myocardial infarction. A randomised trial by the Interuniversity Cardiology Institute in The Netherlands. Lancet. 1985 Sep 14;2(8455):578–582. doi: 10.1016/s0140-6736(85)90584-7. [DOI] [PubMed] [Google Scholar]
  19. Steingart R. M., Packer M., Hamm P., Coglianese M. E., Gersh B., Geltman E. M., Sollano J., Katz S., Moyé L., Basta L. L. Sex differences in the management of coronary artery disease. Survival and Ventricular Enlargement Investigators. N Engl J Med. 1991 Jul 25;325(4):226–230. doi: 10.1056/NEJM199107253250402. [DOI] [PubMed] [Google Scholar]
  20. Tjoe S. L., Luria M. H. Delays in reaching the cardiac care unit: an analysis. Chest. 1972 Jun;61(7):617–621. doi: 10.1378/chest.61.7.617. [DOI] [PubMed] [Google Scholar]
  21. Weaver W. D., White H. D., Wilcox R. G., Aylward P. E., Morris D., Guerci A., Ohman E. M., Barbash G. I., Betriu A., Sadowski Z. Comparisons of characteristics and outcomes among women and men with acute myocardial infarction treated with thrombolytic therapy. GUSTO-I investigators. JAMA. 1996 Mar 13;275(10):777–782. [PubMed] [Google Scholar]
  22. Yarzebski J., Goldberg R. J., Gore J. M., Alpert J. S. Temporal trends and factors associated with extent of delay to hospital arrival in patients with acute myocardial infarction: the Worcester Heart Attack Study. Am Heart J. 1994 Aug;128(2):255–263. doi: 10.1016/0002-8703(94)90477-4. [DOI] [PubMed] [Google Scholar]

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