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. 1997 Nov;65(11):4873–4876. doi: 10.1128/iai.65.11.4873-4876.1997

Plasmodium falciparum- and merozoite surface protein 1-specific antibody isotype balance in immune Senegalese adults.

C M Nguer 1, T O Diallo 1, A Diouf 1, A Tall 1, A Dieye 1, R Perraut 1, O Garraud 1
PMCID: PMC175700  PMID: 9353079

Abstract

This study shows markedly different isotype distributions of antibodies to asexual blood stages of Plasmodium falciparum and to merozoite surface protein 1 in clinically immune Senegalese adults depending on the study site. The relationships between immunoglobulin M (IgM) and IgG and between IgG3 and IgG1 antibodies differed in settings where transmission is perennial compared to settings where it is seasonal. This suggests a role for antibody class and/or subclass production and utilization in the regulation of protective immunity to such antigens.

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Selected References

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