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. 1998 Sep;55(9):627–633. doi: 10.1136/oem.55.9.627

Occupational exposures to solvents and aluminium and estimated risk of Alzheimer's disease

A B Graves, D Rosner, D Echeverria, J A Mortimer, E B Larson
PMCID: PMC1757634  PMID: 9861186

Abstract

OBJECTIVES: To study the role of occupational exposures to solvents and aluminium in the aetiology of Alzheimer's disease (AD). An industrial hygienist rated exposure. METHODS: 89 subjects diagnosed with probable AD were matched by age, sex, and type of informant to 89 controls. Subjects were identified from a large health maintenance organisation in Seattle, WA. A complete occupational history was obtained from spouses of cases and controls as well as from controls themselves. After the interview an industrial hygienist, blinded to case-control status, rated exposures. RESULTS: Non-significant associations were found between AD and ever having been occupationally exposed to solvents (odds ratio (OR) 1.77, 95% confidence interval (95% CI) 0.81 to 3.90) and aluminium (OR 1.46, 95% CI 0.62 to 3.42). Although an increasing risk was found with increasing number of years of exposure to solvents, there was an inverse association between exposure intensity and AD, and measures of cumulative exposure taking into account both intensity and duration of exposure were not significant. Analysis of the age at which half the cumulative exposure to solvents was achieved showed that an older age incurred a greater risk of AD than a younger age. However, the total amount of exposure carried no risk. CONCLUSIONS: The results suggest that lifetime occupational exposure to solvents and aluminium are not likely to be important risk factors for Alzheimer's disease.

 

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Selected References

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  1. Axelson O., Hane M., Hogstedt C. A case-referent study on neuropsychiatric disorders among workers exposed to solvents. Scand J Work Environ Health. 1976 Mar;2(1):14–20. doi: 10.5271/sjweh.2826. [DOI] [PubMed] [Google Scholar]
  2. Belletti I., Troschel L., Pisani P., Berrino F. Retrospective assessment of exposure by experts: the example of formaldehyde, solvents and mineral oils among textile and metal workers. Int J Epidemiol. 1993;22 (Suppl 2):S127–S133. doi: 10.1093/ije/22.supplement_2.s127. [DOI] [PubMed] [Google Scholar]
  3. Bonaiuto S., Rocca W. A., Lippi A., Giannandrea E., Mele M., Cavarzeran F., Amaducci L. Education and occupation as risk factors for dementia: a population-based case-control study. Neuroepidemiology. 1995;14(3):101–109. doi: 10.1159/000109785. [DOI] [PubMed] [Google Scholar]
  4. Breitner J. C., Welsh K. A. Genes and recent developments in the epidemiology of Alzheimer's disease and related dementia. Epidemiol Rev. 1995;17(1):39–47. doi: 10.1093/oxfordjournals.epirev.a036184. [DOI] [PubMed] [Google Scholar]
  5. Cherry N. M., Labrèche F. P., McDonald J. C. Organic brain damage and occupational solvent exposure. Br J Ind Med. 1992 Nov;49(11):776–781. doi: 10.1136/oem.49.11.776. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Cherry N., Venables H., Waldron H. A. British studies on the neuropsychological effects of solvent exposure. Scand J Work Environ Health. 1984;10 (Suppl 1):10–12. [PubMed] [Google Scholar]
  7. Corder E. H., Saunders A. M., Strittmatter W. J., Schmechel D. E., Gaskell P. C., Small G. W., Roses A. D., Haines J. L., Pericak-Vance M. A. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science. 1993 Aug 13;261(5123):921–923. doi: 10.1126/science.8346443. [DOI] [PubMed] [Google Scholar]
  8. Doll R. Review: Alzheimer's disease and environmental aluminium. Age Ageing. 1993 Mar;22(2):138–153. doi: 10.1093/ageing/22.2.138. [DOI] [PubMed] [Google Scholar]
  9. Echeverria D., White R. F., Sampaio C. A behavioral evaluation of PCE exposure in patients and dry cleaners: a possible relationship between clinical and preclinical effects. J Occup Environ Med. 1995 Jun;37(6):667–680. doi: 10.1097/00043764-199506000-00008. [DOI] [PubMed] [Google Scholar]
  10. Folstein M. F., Folstein S. E., McHugh P. R. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975 Nov;12(3):189–198. doi: 10.1016/0022-3956(75)90026-6. [DOI] [PubMed] [Google Scholar]
  11. Ford D. P., Schwartz B. S., Powell S., Nelson T., Keller L., Sides S., Agnew J., Bolla K., Bleecker M. A quantitative approach to the characterization of cumulative and average solvent exposure in paint manufacturing plants. Am Ind Hyg Assoc J. 1991 Jun;52(6):226–234. doi: 10.1080/15298669191364640. [DOI] [PubMed] [Google Scholar]
  12. French L. R., Schuman L. M., Mortimer J. A., Hutton J. T., Boatman R. A., Christians B. A case-control study of dementia of the Alzheimer type. Am J Epidemiol. 1985 Mar;121(3):414–421. doi: 10.1093/oxfordjournals.aje.a114013. [DOI] [PubMed] [Google Scholar]
  13. Graves A. B., White E., Koepsell T. D., Reifler B. V., van Belle G., Larson E. B. The association between aluminum-containing products and Alzheimer's disease. J Clin Epidemiol. 1990;43(1):35–44. doi: 10.1016/0895-4356(90)90053-r. [DOI] [PubMed] [Google Scholar]
  14. Graves A. B., van Duijn C. M., Chandra V., Fratiglioni L., Heyman A., Jorm A. F., Kokmen E., Kondo K., Mortimer J. A., Rocca W. A. Occupational exposures to solvents and lead as risk factors for Alzheimer's disease: a collaborative re-analysis of case-control studies. EURODEM Risk Factors Research Group. Int J Epidemiol. 1991;20 (Suppl 2):S58–S61. doi: 10.1093/ije/20.supplement_2.s58. [DOI] [PubMed] [Google Scholar]
  15. Gun R. T., Korten A. E., Jorm A. F., Henderson A. S., Broe G. A., Creasey H., McCusker E., Mylvaganam A. Occupational risk factors for Alzheimer disease: a case-control study. Alzheimer Dis Assoc Disord. 1997 Mar;11(1):21–27. doi: 10.1097/00002093-199703000-00005. [DOI] [PubMed] [Google Scholar]
  16. Hardy J. Alzheimer's disease. Clinical molecular genetics. Clin Geriatr Med. 1994 May;10(2):239–247. [PubMed] [Google Scholar]
  17. Heyman A., Wilkinson W. E., Stafford J. A., Helms M. J., Sigmon A. H., Weinberg T. Alzheimer's disease: a study of epidemiological aspects. Ann Neurol. 1984 Apr;15(4):335–341. doi: 10.1002/ana.410150406. [DOI] [PubMed] [Google Scholar]
  18. KLATZO I., WISNIEWSKI H., STREICHER E. EXPERIMENTAL PRODUCTION OF NEUROFIBRILLARY DEGENERATION. I. LIGHT MICROSCOPIC OBSERVATIONS. J Neuropathol Exp Neurol. 1965 Apr;24:187–199. doi: 10.1097/00005072-196504000-00002. [DOI] [PubMed] [Google Scholar]
  19. Kukull W. A., Hinds T. R., Schellenberg G. D., van Belle G., Larson E. B. Increased platelet membrane fluidity as a diagnostic marker for Alzheimer's disease: a test in population-based cases and controls. Neurology. 1992 Mar;42(3 Pt 1):607–614. doi: 10.1212/wnl.42.3.607. [DOI] [PubMed] [Google Scholar]
  20. Kukull W. A., Larson E. B., Bowen J. D., McCormick W. C., Teri L., Pfanschmidt M. L., Thompson J. D., O'Meara E. S., Brenner D. E., van Belle G. Solvent exposure as a risk factor for Alzheimer's disease: a case-control study. Am J Epidemiol. 1995 Jun 1;141(11):1059–1079. doi: 10.1093/oxfordjournals.aje.a117370. [DOI] [PubMed] [Google Scholar]
  21. Labrèche F. P., Cherry N. M., McDonald J. C. Psychiatric disorders and occupational exposure to solvents. Br J Ind Med. 1992 Dec;49(12):820–825. doi: 10.1136/oem.49.12.820. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Landsberg J. P., McDonald B., Watt F. Absence of aluminium in neuritic plaque cores in Alzheimer's disease. Nature. 1992 Nov 5;360(6399):65–68. doi: 10.1038/360065a0. [DOI] [PubMed] [Google Scholar]
  23. Larson E. B., Kukull W. A., Teri L., McCormick W., Pfanschmidt M., van Belle G., Sumi M. University of Washington Alzheimer's Disease Patient Registry (ADPR): 1987-1988. Aging (Milano) 1990 Dec;2(4):404–408. [PubMed] [Google Scholar]
  24. Lehrl S., Triebig G., Fischer B. Multiple choice vocabulary test MWT as a valid and short test to estimate premorbid intelligence. Acta Neurol Scand. 1995 May;91(5):335–345. doi: 10.1111/j.1600-0404.1995.tb07018.x. [DOI] [PubMed] [Google Scholar]
  25. Li G., Shen Y. C., Chen C. H., Zhau Y. W., Li S. R., Lu M. A three-year follow-up study of age-related dementia in an urban area of Beijing. Acta Psychiatr Scand. 1991 Feb;83(2):99–104. doi: 10.1111/j.1600-0447.1991.tb07373.x. [DOI] [PubMed] [Google Scholar]
  26. McCall R. B. Childhood IQ's as Predictors of Adult Educational and Occupational Status. Science. 1977 Jul 29;197(4302):482–483. doi: 10.1126/science.197.4302.482. [DOI] [PubMed] [Google Scholar]
  27. McGeer P. L., Schulzer M., McGeer E. G. Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies. Neurology. 1996 Aug;47(2):425–432. doi: 10.1212/wnl.47.2.425. [DOI] [PubMed] [Google Scholar]
  28. McKhann G., Drachman D., Folstein M., Katzman R., Price D., Stadlan E. M. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984 Jul;34(7):939–944. doi: 10.1212/wnl.34.7.939. [DOI] [PubMed] [Google Scholar]
  29. Mikkelsen S. A cohort study of disability pension and death among painters with special regard to disabling presenile dementia as an occupational disease. Scand J Soc Med Suppl. 1980;16:34–43. [PubMed] [Google Scholar]
  30. Mutti A., Mazzucchi A., Rustichelli P., Frigeri G., Arfini G., Franchini I. Exposure-effect and exposure-response relationships between occupational exposure to styrene and neuropsychological functions. Am J Ind Med. 1984;5(4):275–286. doi: 10.1002/ajim.4700050404. [DOI] [PubMed] [Google Scholar]
  31. O'Flynn R. R., Monkman S. M., Waldron H. A. Organic solvents and presenile dementia: a case referent study using death certificates. Br J Ind Med. 1987 Apr;44(4):259–262. doi: 10.1136/oem.44.4.259. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Perl D. P., Brody A. R. Alzheimer's disease: X-ray spectrometric evidence of aluminum accumulation in neurofibrillary tangle-bearing neurons. Science. 1980 Apr 18;208(4441):297–299. doi: 10.1126/science.7367858. [DOI] [PubMed] [Google Scholar]
  33. Rifat S. L., Eastwood M. R., McLachlan D. R., Corey P. N. Effect of exposure of miners to aluminium powder. Lancet. 1990 Nov 10;336(8724):1162–1165. doi: 10.1016/0140-6736(90)92775-d. [DOI] [PubMed] [Google Scholar]
  34. Shalat S. L., Seltzer B., Baker E. L., Jr Occupational risk factors and Alzheimer's disease: a case-control study. J Occup Med. 1988 Dec;30(12):934–936. doi: 10.1097/00043764-198812000-00010. [DOI] [PubMed] [Google Scholar]
  35. Shalat S. L., Seltzer B., Pidcock C., Baker E. L., Jr Risk factors for Alzheimer's disease: a case-control study. Neurology. 1987 Oct;37(10):1630–1633. doi: 10.1212/wnl.37.10.1630. [DOI] [PubMed] [Google Scholar]
  36. Stern Y., Gurland B., Tatemichi T. K., Tang M. X., Wilder D., Mayeux R. Influence of education and occupation on the incidence of Alzheimer's disease. JAMA. 1994 Apr 6;271(13):1004–1010. [PubMed] [Google Scholar]
  37. Stewart P. A., Stewart W. F. Occupational case-control studies: II. Recommendations for exposure assessment. Am J Ind Med. 1994 Sep;26(3):313–326. doi: 10.1002/ajim.4700260305. [DOI] [PubMed] [Google Scholar]
  38. Strittmatter W. J., Saunders A. M., Schmechel D., Pericak-Vance M., Enghild J., Salvesen G. S., Roses A. D. Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1977–1981. doi: 10.1073/pnas.90.5.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. Tang M. X., Jacobs D., Stern Y., Marder K., Schofield P., Gurland B., Andrews H., Mayeux R. Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease. Lancet. 1996 Aug 17;348(9025):429–432. doi: 10.1016/S0140-6736(96)03356-9. [DOI] [PubMed] [Google Scholar]
  40. White R. F., Proctor S. P., Echeverria D., Schweikert J., Feldman R. G. Neurobehavioral effects of acute and chronic mixed-solvent exposure in the screen printing industry. Am J Ind Med. 1995 Aug;28(2):221–231. doi: 10.1002/ajim.4700280207. [DOI] [PubMed] [Google Scholar]
  41. Wisniewski H. M., Sturman J. A., Shek J. W. Aluminum chloride induced neurofibrillary changes in the developing rabbit a chronic animal model. Ann Neurol. 1980 Nov;8(5):479–490. doi: 10.1002/ana.410080505. [DOI] [PubMed] [Google Scholar]
  42. van Duijn C. M., Clayton D., Chandra V., Fratiglioni L., Graves A. B., Heyman A., Jorm A. F., Kokmen E., Kondo K., Mortimer J. A. Familial aggregation of Alzheimer's disease and related disorders: a collaborative re-analysis of case-control studies. Int J Epidemiol. 1991;20 (Suppl 2):S13–S20. doi: 10.1093/ije/20.supplement_2.s13. [DOI] [PubMed] [Google Scholar]
  43. van Duijn C. M., Havekes L. M., Van Broeckhoven C., de Knijff P., Hofman A. Apolipoprotein E genotype and association between smoking and early onset Alzheimer's disease. BMJ. 1995 Mar 11;310(6980):627–631. doi: 10.1136/bmj.310.6980.627. [DOI] [PMC free article] [PubMed] [Google Scholar]

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