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. 1997 Dec;65(12):5334–5337. doi: 10.1128/iai.65.12.5334-5337.1997

CD8+ T cells are activated during the early Th1 and Th2 immune responses in a murine Lyme disease model.

Z Dong 1, M D Edelstein 1, L J Glickstein 1
PMCID: PMC175768  PMID: 9393835

Abstract

T-helper responses following Borrelia burgdorferi infection in mice determine susceptibility to Lyme arthritis. The ratio of interleukin 4-positive, CD4+ to gamma interferon (IFN-gamma)-positive, CD4+ T cells was significantly greater in infected BALB/cJ mice than in infected C3H/HeJ mice. Increased numbers of IFN-gamma-producing cells predicted greater arthritis severity, and CD8+ T cells were the main source of IFN-gamma in both strains.

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Selected References

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