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. 2004 Jan;61(1):57–64.

Mortality among a cohort of uranium mill workers: an update

L Pinkerton 1, T Bloom 1, M Hein 1, E Ward 1
PMCID: PMC1757824  PMID: 14691274

Abstract

Aims: To evaluate the mortality experience of 1484 men employed in seven uranium mills in the Colorado Plateau for at least one year on or after 1 January 1940.

Methods: Vital status was updated through 1998, and life table analyses were conducted.

Results: Mortality from all causes and all cancers was less than expected based on US mortality rates. A statistically significant increase in non-malignant respiratory disease mortality and non-significant increases in mortality from lymphatic and haematopoietic malignancies other than leukaemia, lung cancer, and chronic renal disease were observed. The excess in lymphatic and haematopoietic cancer mortality was due to an increase in mortality from lymphosarcoma and reticulosarcoma and Hodgkin's disease. Within the category of non-malignant respiratory disease, mortality from emphysema and pneumoconioses and other respiratory disease was increased. Mortality from lung cancer and emphysema was higher among workers hired prior to 1955 when exposures to uranium, silica, and vanadium were presumably higher. Mortality from these causes of death did not increase with employment duration.

Conclusions: Although the observed excesses were consistent with our a priori hypotheses, positive trends with employment duration were not observed. Limitations included the small cohort size and limited power to detect a moderately increased risk for some outcomes of interest, the inability to estimate individual exposures, and the lack of smoking data. Because of these limitations, firm conclusions about the relation of the observed excesses in mortality and mill exposures are not possible.

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Selected References

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  1. Arrighi H. M., Hertz-Picciotto I. The evolving concept of the healthy worker survivor effect. Epidemiology. 1994 Mar;5(2):189–196. doi: 10.1097/00001648-199403000-00009. [DOI] [PubMed] [Google Scholar]
  2. Barceloux D. G. Vanadium. J Toxicol Clin Toxicol. 1999;37(2):265–278. doi: 10.1081/clt-100102425. [DOI] [PubMed] [Google Scholar]
  3. Calvert G. M., Steenland K., Palu S. End-stage renal disease among silica-exposed gold miners. A new method for assessing incidence among epidemiologic cohorts. JAMA. 1997 Apr 16;277(15):1219–1223. [PubMed] [Google Scholar]
  4. Checkoway H., Heyer N. J., Seixas N. S., Welp E. A., Demers P. A., Hughes J. M., Weill H. Dose-response associations of silica with nonmalignant respiratory disease and lung cancer mortality in the diatomaceous earth industry. Am J Epidemiol. 1997 Apr 15;145(8):680–688. doi: 10.1093/aje/145.8.680. [DOI] [PubMed] [Google Scholar]
  5. Cross F. T., Palmer R. F., Busch R. H., Filipy R. E., Stuart B. O. Development of lesions in Syrian golden hamsters following exposure to radon daughters and uranium ore dust. Health Phys. 1981 Jul;41(1):135–153. doi: 10.1097/00004032-198107000-00012. [DOI] [PubMed] [Google Scholar]
  6. Cross F. T., Palmer R. F., Filipy R. E., Dagle G. E., Stuart B. O. Carcinogenic effects of radon daughters, uranium ore dust and cigarette smoke in beagle dogs. Health Phys. 1982 Jan;42(1):33–52. doi: 10.1097/00004032-198201000-00004. [DOI] [PubMed] [Google Scholar]
  7. Darby S. C., Whitley E., Howe G. R., Hutchings S. J., Kusiak R. A., Lubin J. H., Morrison H. I., Tirmarche M., Tomásek L., Radford E. P. Radon and cancers other than lung cancer in underground miners: a collaborative analysis of 11 studies. J Natl Cancer Inst. 1995 Mar 1;87(5):378–384. doi: 10.1093/jnci/87.5.378. [DOI] [PubMed] [Google Scholar]
  8. Dupree-Ellis E., Watkins J., Ingle J. N., Phillips J. External radiation exposure and mortality in a cohort of uranium processing workers. Am J Epidemiol. 2000 Jul 1;152(1):91–95. doi: 10.1093/aje/152.1.91. [DOI] [PubMed] [Google Scholar]
  9. Finkelstein M. M. Silica, silicosis, and lung cancer: a risk assessment. Am J Ind Med. 2000 Jul;38(1):8–18. doi: 10.1002/1097-0274(200007)38:1<8::aid-ajim2>3.0.co;2-#. [DOI] [PubMed] [Google Scholar]
  10. Hornung R. W. Health effects in underground uranium miners. Occup Med. 2001 Apr-Jun;16(2):331–344. [PubMed] [Google Scholar]
  11. Hornung R. W., Meinhardt T. J. Quantitative risk assessment of lung cancer in U.S. uranium miners. Health Phys. 1987 Apr;52(4):417–430. doi: 10.1097/00004032-198704000-00002. [DOI] [PubMed] [Google Scholar]
  12. Hryhorczuk D. O., Aks S. E., Turk J. W. Unusual occupational toxins. Occup Med. 1992 Jul-Sep;7(3):567–586. [PubMed] [Google Scholar]
  13. Keane A. T., Polednak A. P. Retention of uranium in the chest: implications of findings in vivo and postmortem. Health Phys. 1983;44 (Suppl 1):391–402. doi: 10.1097/00004032-198306001-00037. [DOI] [PubMed] [Google Scholar]
  14. Leach L. J., Yuile C. L., Hodge H. C., Sylvester G. E., Wilson H. B. A five-year inhalation study with natural uranium dioxide (UO2) dust. II. Postexposure retention and biologic effects in the monkey, dog and rat. Health Phys. 1973 Sep;25(3):239–258. doi: 10.1097/00004032-197309000-00003. [DOI] [PubMed] [Google Scholar]
  15. Liu Z., Lee T. S., Kotek T. J. Mortality among workers in a thorium-processing plant--a second follow-up. Scand J Work Environ Health. 1992 Jun;18(3):162–168. doi: 10.5271/sjweh.1592. [DOI] [PubMed] [Google Scholar]
  16. Loomis D. P., Wolf S. H. Mortality of workers at a nuclear materials production plant at Oak Ridge, Tennessee, 1947-1990. Am J Ind Med. 1996 Feb;29(2):131–141. doi: 10.1002/(SICI)1097-0274(199602)29:2<131::AID-AJIM3>3.0.CO;2-V. [DOI] [PubMed] [Google Scholar]
  17. Lubin J. H., Boice J. D., Jr, Edling C., Hornung R. W., Howe G. R., Kunz E., Kusiak R. A., Morrison H. I., Radford E. P., Samet J. M. Lung cancer in radon-exposed miners and estimation of risk from indoor exposure. J Natl Cancer Inst. 1995 Jun 7;87(11):817–827. doi: 10.1093/jnci/87.11.817. [DOI] [PubMed] [Google Scholar]
  18. Mausner L. F. Inhalation exposures at a thorium refinery. Health Phys. 1982 Feb;42(2):231–236. [PubMed] [Google Scholar]
  19. McGeoghegan D., Binks K. The mortality and cancer morbidity experience of workers at the Springfields uranium production facility, 1946-95. J Radiol Prot. 2000 Jun;20(2):111–137. doi: 10.1088/0952-4746/20/2/301. [DOI] [PubMed] [Google Scholar]
  20. Mitchel R. E., Jackson J. S., Heinmiller B. Inhaled uranium ore dust and lung cancer risk in rats. Health Phys. 1999 Feb;76(2):145–155. doi: 10.1097/00004032-199902000-00006. [DOI] [PubMed] [Google Scholar]
  21. Ritz B. Radiation exposure and cancer mortality in uranium processing workers. Epidemiology. 1999 Sep;10(5):531–538. [PubMed] [Google Scholar]
  22. Roscoe R. J. An update of mortality from all causes among white uranium miners from the Colorado Plateau Study Group. Am J Ind Med. 1997 Feb;31(2):211–222. doi: 10.1002/(sici)1097-0274(199702)31:2<211::aid-ajim11>3.0.co;2-4. [DOI] [PubMed] [Google Scholar]
  23. Siemiatycki J., Wacholder S., Dewar R., Cardis E., Greenwood C., Richardson L. Degree of confounding bias related to smoking, ethnic group, and socioeconomic status in estimates of the associations between occupation and cancer. J Occup Med. 1988 Aug;30(8):617–625. doi: 10.1097/00043764-198808000-00004. [DOI] [PubMed] [Google Scholar]
  24. Singh N. P., Bennett D. D., Wrenn M. E., Saccomanno G. Concentrations of alpha-emitting isotopes of U and Th in uranium miners' and millers' tissues. Health Phys. 1987 Sep;53(3):261–265. doi: 10.1097/00004032-198709000-00005. [DOI] [PubMed] [Google Scholar]
  25. Steenland K., Beaumont J., Spaeth S., Brown D., Okun A., Jurcenko L., Ryan B., Phillips S., Roscoe R., Stayner L. New developments in the Life Table Analysis System of the National Institute for Occupational Safety and Health. J Occup Med. 1990 Nov;32(11):1091–1098. doi: 10.1097/00043764-199011000-00008. [DOI] [PubMed] [Google Scholar]
  26. Steenland K., Brown D. Mortality study of gold miners exposed to silica and nonasbestiform amphibole minerals: an update with 14 more years of follow-up. Am J Ind Med. 1995 Feb;27(2):217–229. doi: 10.1002/ajim.4700270207. [DOI] [PubMed] [Google Scholar]
  27. Steenland K., Nowlin S., Ryan B., Adams S. Use of multiple-cause mortality data in epidemiologic analyses: US rate and proportion files developed by the National Institute for Occupational Safety and Health and the National Cancer Institute. Am J Epidemiol. 1992 Oct 1;136(7):855–862. doi: 10.1093/aje/136.7.855. [DOI] [PubMed] [Google Scholar]
  28. Steenland K., Sanderson W., Calvert G. M. Kidney disease and arthritis in a cohort study of workers exposed to silica. Epidemiology. 2001 Jul;12(4):405–412. doi: 10.1097/00001648-200107000-00010. [DOI] [PubMed] [Google Scholar]
  29. Steenland K., Sanderson W. Lung cancer among industrial sand workers exposed to crystalline silica. Am J Epidemiol. 2001 Apr 1;153(7):695–703. doi: 10.1093/aje/153.7.695. [DOI] [PubMed] [Google Scholar]
  30. Steenland K., Spaeth S., Cassinelli R., 2nd, Laber P., Chang L., Koch K. NIOSH life table program for personal computers. Am J Ind Med. 1998 Nov;34(5):517–518. doi: 10.1002/(sici)1097-0274(199811)34:5<517::aid-ajim14>3.0.co;2-4. [DOI] [PubMed] [Google Scholar]
  31. Thun M. J., Baker D. B., Steenland K., Smith A. B., Halperin W., Berl T. Renal toxicity in uranium mill workers. Scand J Work Environ Health. 1985 Apr;11(2):83–90. doi: 10.5271/sjweh.2249. [DOI] [PubMed] [Google Scholar]
  32. Waxweiler R. J., Beaumont J. J., Henry J. A., Brown D. P., Robinson C. F., Ness G. O., Wagoner J. K., Lemen R. A. A modified life-table analysis system for cohort studies. J Occup Med. 1983 Feb;25(2):115–124. [PubMed] [Google Scholar]
  33. Weinhold B. Death out West: the link to COPD. Environ Health Perspect. 2000 Aug;108(8):A350–A350. doi: 10.1289/ehp.108-a350. [DOI] [PMC free article] [PubMed] [Google Scholar]

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