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. 1997 Feb;52(2):166–170. doi: 10.1136/thx.52.2.166

Bronchial reactivity and dietary antioxidants

A Soutar, A Seaton, K Brown
PMCID: PMC1758477  PMID: 9059479

Abstract

BACKGROUND: It has been postulated that dietary antioxidants may influence the expression of allergic diseases and asthma. To test this hypothesis a case-control study was performed, nested in a cross sectional study of a random sample of adults, to investigate the relationship between allergic disease and dietary antioxidants. METHODS: The study was performed in rural general practices in Grampian, Scotland. A validated dietary questionnaire was used to measure food intake of cases, defined, firstly, as people with seasonal allergic-type symptoms and, secondly, those with bronchial hyperreactivity confirmed by methacholine challenge, and of controls without allergic symptoms or bronchial reactivity. RESULTS: Cases with seasonal symptoms did not differ from controls except with respect to the presence of atopy and an increased risk of symptoms associated with the lowest intake of zinc. The lowest intakes of vitamin C and manganese were associated with more than fivefold increased risks of bronchial reactivity. Decreasing intakes of magnesium were also significantly associated with an increased risk of hyperreactivity. CONCLUSIONS: This study provides evidence that diet may have a modulatory effect on bronchial reactivity, and is consistent with the hypothesis that the observed reduction in antioxidant intake in the British diet over the last 25 years has been a factor in the increase in the prevalence of asthma over this period. 




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Selected References

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  1. Bolton-Smith C., Smith W. C., Woodward M., Tunstall-Pedoe H. Nutrient intakes of different social-class groups: results from the Scottish Heart Health Study (SHHS). Br J Nutr. 1991 May;65(3):321–335. doi: 10.1079/bjn19910093. [DOI] [PubMed] [Google Scholar]
  2. Britton J., Pavord I., Richards K., Wisniewski A., Knox A., Lewis S., Tattersfield A., Weiss S. Dietary magnesium, lung function, wheezing, and airway hyperreactivity in a random adult population sample. Lancet. 1994 Aug 6;344(8919):357–362. doi: 10.1016/s0140-6736(94)91399-4. [DOI] [PubMed] [Google Scholar]
  3. Cockcroft D. W., Berscheid B. A. Slope of the dose-response curve: usefulness in assessing bronchial responses to inhaled histamine. Thorax. 1983 Jan;38(1):55–61. doi: 10.1136/thx.38.1.55. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Mohsenin V. Effect of vitamin C on NO2-induced airway hyperresponsiveness in normal subjects. A randomized double-blind experiment. Am Rev Respir Dis. 1987 Dec;136(6):1408–1411. doi: 10.1164/ajrccm/136.6.1408. [DOI] [PubMed] [Google Scholar]
  5. Morabia A., Menkes M. J., Comstock G. W., Tockman M. S. Serum retinol and airway obstruction. Am J Epidemiol. 1990 Jul;132(1):77–82. doi: 10.1093/oxfordjournals.aje.a115645. [DOI] [PubMed] [Google Scholar]
  6. Ninan T. K., Russell G. Respiratory symptoms and atopy in Aberdeen schoolchildren: evidence from two surveys 25 years apart. BMJ. 1992 Apr 4;304(6831):873–875. doi: 10.1136/bmj.304.6831.873. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Robertson C. F., Heycock E., Bishop J., Nolan T., Olinsky A., Phelan P. D. Prevalence of asthma in Melbourne schoolchildren: changes over 26 years. BMJ. 1991 May 11;302(6785):1116–1118. doi: 10.1136/bmj.302.6785.1116. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Schwartz J., Weiss S. T. Dietary factors and their relation to respiratory symptoms. The Second National Health and Nutrition Examination Survey. Am J Epidemiol. 1990 Jul;132(1):67–76. doi: 10.1093/oxfordjournals.aje.a115644. [DOI] [PubMed] [Google Scholar]
  9. Schwartz J., Weiss S. T. Relationship between dietary vitamin C intake and pulmonary function in the First National Health and Nutrition Examination Survey (NHANES I). Am J Clin Nutr. 1994 Jan;59(1):110–114. doi: 10.1093/ajcn/59.1.110. [DOI] [PubMed] [Google Scholar]
  10. Seaton A., Godden D. J., Brown K. Increase in asthma: a more toxic environment or a more susceptible population? Thorax. 1994 Feb;49(2):171–174. doi: 10.1136/thx.49.2.171. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Shaheen S. O., Aaby P., Hall A. J., Barker D. J., Heyes C. B., Shiell A. W., Goudiaby A. Measles and atopy in Guinea-Bissau. Lancet. 1996 Jun 29;347(9018):1792–1796. doi: 10.1016/s0140-6736(96)91617-7. [DOI] [PubMed] [Google Scholar]
  12. Soutar A., Harker C., Seaton A., Brooke M., Marr I. Oilseed rape and seasonal symptoms: epidemiological and environmental studies. Thorax. 1994 Apr;49(4):352–356. doi: 10.1136/thx.49.4.352. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Stone J., Hinks L. J., Beasley R., Holgate S. T., Clayton B. A. Reduced selenium status of patients with asthma. Clin Sci (Lond) 1989 Nov;77(5):495–500. doi: 10.1042/cs0770495. [DOI] [PubMed] [Google Scholar]
  14. Strachan D. P., Cox B. D., Erzinclioglu S. W., Walters D. E., Whichelow M. J. Ventilatory function and winter fresh fruit consumption in a random sample of British adults. Thorax. 1991 Sep;46(9):624–629. doi: 10.1136/thx.46.9.624. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. von Mutius E., Martinez F. D., Fritzsch C., Nicolai T., Reitmeir P., Thiemann H. H. Skin test reactivity and number of siblings. BMJ. 1994 Mar 12;308(6930):692–695. doi: 10.1136/bmj.308.6930.692. [DOI] [PMC free article] [PubMed] [Google Scholar]

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