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. 1997 Feb;52(2):190–194. doi: 10.1136/thx.52.2.190

Does influenza immunisation cause exacerbations of chronic airflow obstruction or asthma?

J M Watson, J F Cordier, K G Nicholson
PMCID: PMC1758497  PMID: 9059485

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Atmar R. L., Bloom K., Keitel W., Couch R. B., Greenberg S. B. Effect of live attenuated, cold recombinant (CR) influenza virus vaccines on pulmonary function in healthy and asthmatic adults. Vaccine. 1990 Jun;8(3):217–224. doi: 10.1016/0264-410x(90)90049-r. [DOI] [PubMed] [Google Scholar]
  2. Bell T. D., Chai H., Berlow B., Daniels G. Immunization with killed influenza virus in children with chronic asthma. Chest. 1978 Feb;73(2):140–145. doi: 10.1378/chest.73.2.140. [DOI] [PubMed] [Google Scholar]
  3. Campbell B. G., Edwards R. L. Safety of influenza vaccination in adults with asthma. Med J Aust. 1984 Jun 23;140(13):773–775. doi: 10.5694/j.1326-5377.1984.tb132595.x. [DOI] [PubMed] [Google Scholar]
  4. Fleming D. M., Cross K. W. Respiratory syncytial virus or influenza? Lancet. 1993 Dec 18;342(8886-8887):1507–1510. doi: 10.1016/s0140-6736(05)80082-0. [DOI] [PubMed] [Google Scholar]
  5. Glezen W. P. Serious morbidity and mortality associated with influenza epidemics. Epidemiol Rev. 1982;4:25–44. doi: 10.1093/oxfordjournals.epirev.a036250. [DOI] [PubMed] [Google Scholar]
  6. Govaert T. M., Dinant G. J., Aretz K., Masurel N., Sprenger M. J., Knottnerus J. A. Adverse reactions to influenza vaccine in elderly people: randomised double blind placebo controlled trial. BMJ. 1993 Oct 16;307(6910):988–990. doi: 10.1136/bmj.307.6910.988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hassan W. U., Henderson A. F., Keaney N. P. Influenza vaccination in asthma. Lancet. 1992 Jan 18;339(8786):194–194. doi: 10.1016/0140-6736(92)90274-7. [DOI] [PubMed] [Google Scholar]
  8. Housworth J., Langmuir A. D. Excess mortality from epidemic influenza, 1957-1966. Am J Epidemiol. 1974 Jul;100(1):40–48. doi: 10.1093/oxfordjournals.aje.a112007. [DOI] [PubMed] [Google Scholar]
  9. Kava T. Acute respiratory infection, influenza vaccination and airway reactivity in asthma. Eur J Respir Dis Suppl. 1987;150:1–38. [PubMed] [Google Scholar]
  10. Kava T., Lindqvist A., Karjalainen J., Laitinen L. A. Unchanged bronchial reactivity after killed influenza virus vaccine in adult asthmatics. Respiration. 1987;51(2):98–104. doi: 10.1159/000195173. [DOI] [PubMed] [Google Scholar]
  11. Knowles G. K., Taylor P., Turner-Warwick M. A comparison of antibody responses to Admune inactivated influenza vaccine in serum and respiratory secretions of healthy non-smokers, healthy cigarette-smokers and patients with chronic bronchitis. Br J Dis Chest. 1981 Jul;75(3):283–290. doi: 10.1016/0007-0971(81)90007-3. [DOI] [PubMed] [Google Scholar]
  12. Kondo S., Abe K. The effects of influenza virus infection on FEV1 in asthmatic children. The time-course study. Chest. 1991 Nov;100(5):1235–1238. doi: 10.1378/chest.100.5.1235. [DOI] [PubMed] [Google Scholar]
  13. Laitinen L. A., Elkin R. B., Empey D. W., Jacobs L., Mills J., Nadel J. A. Bronchial hyperresponsiveness in normal subjects during attenuated influenza virus infection. Am Rev Respir Dis. 1991 Feb;143(2):358–361. doi: 10.1164/ajrccm/143.2.358. [DOI] [PubMed] [Google Scholar]
  14. Margolis K. L., Nichol K. L., Poland G. A., Pluhar R. E. Frequency of adverse reactions to influenza vaccine in the elderly. A randomized, placebo-controlled trial. JAMA. 1990 Sep 5;264(9):1139–1141. [PubMed] [Google Scholar]
  15. Margolis K. L., Poland G. A., Nichol K. L., MacPherson D. S., Meyer J. D., Korn J. E., Lofgren R. P. Frequency of adverse reactions after influenza vaccination. Am J Med. 1990 Jan;88(1):27–30. doi: 10.1016/0002-9343(90)90123-u. [DOI] [PubMed] [Google Scholar]
  16. McIntosh K., Ellis E. F., Hoffman L. S., Lybass T. G., Eller J. J., Fulginiti V. A. The association of viral and bacterial respiratory infections with exacerbations of wheezing in young asthmatic children. J Pediatr. 1973 Apr;82(4):578–590. doi: 10.1016/S0022-3476(73)80582-7. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Minor T. E., Dick E. C., DeMeo A. N., Ouellette J. J., Cohen M., Reed C. E. Viruses as precipitants of asthmatic attacks in children. JAMA. 1974 Jan 21;227(3):292–298. [PubMed] [Google Scholar]
  18. Murphy K. R., Strunk R. C. Safe administration of influenza vaccine in asthmatic children hypersensitive to egg proteins. J Pediatr. 1985 Jun;106(6):931–933. doi: 10.1016/s0022-3476(85)80241-9. [DOI] [PubMed] [Google Scholar]
  19. Nguyen-Van-Tam J. S., Nicholson K. G. Influenza immunization; vaccine offer, request and uptake in high-risk patients during the 1991/2 season. Epidemiol Infect. 1993 Oct;111(2):347–355. doi: 10.1017/s0950268800057058. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Nguyen-van-Tam J. S., Nicholson K. G. Influenza deaths in Leicestershire during the 1989-90 epidemic: implications for prevention. Epidemiol Infect. 1992 Jun;108(3):537–545. doi: 10.1017/s0950268800050032. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Nicholson K. G., Baker D. J., Farquhar A., Hurd D., Kent J., Smith S. H. Acute upper respiratory tract viral illness and influenza immunization in homes for the elderly. Epidemiol Infect. 1990 Dec;105(3):609–618. doi: 10.1017/s0950268800048251. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Nicholson K. G., Kent J., Ireland D. C. Respiratory viruses and exacerbations of asthma in adults. BMJ. 1993 Oct 16;307(6910):982–986. doi: 10.1136/bmj.307.6910.982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Nicholson K. G., Snacken R., Palache A. M. Influenza immunization policies in Europe and the United States. Vaccine. 1995 Mar;13(4):365–369. doi: 10.1016/0264-410x(95)98258-c. [DOI] [PubMed] [Google Scholar]
  24. Ouellette J. J., Reed C. E. Increased response of asthmatic subjects to methacholine after influenza vaccine. J Allergy. 1965 Nov-Dec;36(6):558–563. doi: 10.1016/0021-8707(65)90193-0. [DOI] [PubMed] [Google Scholar]
  25. Prevost J. M., Vereerstraeten-Schmerber J., Lamy F., De Koster J. P. Live attenuated influenza virus vaccines in patients with chronic broncho-pulmonary diseases. Clinical and immunological evaluation. Scand J Respir Dis. 1975 May;56(1):58–69. [PubMed] [Google Scholar]
  26. Rohrer J. W., Hamilton G. G. Surveillance of the swine influenza vaccination program at the Royal Military College, Kingston. Can Med Assoc J. 1978 Jun 24;118(12):1528–1530. [PMC free article] [PubMed] [Google Scholar]
  27. Rothbarth P. H., Kempen B. M., Sprenger M. J. Sense and nonsense of influenza vaccination in asthma and chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1995 May;151(5):1682–1686. doi: 10.1164/ajrccm/151.5_Pt_1.1682. [DOI] [PubMed] [Google Scholar]
  28. Scheifele D. W., Bjornson G., Johnston J. Evaluation of adverse events after influenza vaccination in hospital personnel. CMAJ. 1990 Jan 15;142(2):127–130. [PMC free article] [PubMed] [Google Scholar]
  29. Smith C. B., Golden C. A., Kanner R. E., Renzetti A. D., Jr Association of viral and Mycoplasma pneumoniae infections with acute respiratory illness in patients with chronic obstructive pulmonary diseases. Am Rev Respir Dis. 1980 Feb;121(2):225–232. doi: 10.1164/arrd.1980.121.2.225. [DOI] [PubMed] [Google Scholar]
  30. Stenius-Aarniala B., Huttunen J. K., Pyhälä R., Haahtela T., Jokela P., Jukkara A., Karakorpi T., Kataja M., Kava T., Kuusisto P. Lack of clinical exacerbations in adults with chronic asthma after immunization with killed influenza virus. Chest. 1986 Jun;89(6):786–789. doi: 10.1378/chest.89.6.786. [DOI] [PubMed] [Google Scholar]
  31. al-Mazrou A., Scheifele D. W., Soong T., Bjornson G. Comparison of adverse reactions to whole-virion and split-virion influenza vaccines in hospital personnel. CMAJ. 1991 Aug 1;145(3):213–218. [PMC free article] [PubMed] [Google Scholar]

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