Abstract
BACKGROUND: The incidence of lung cancer is increased in patients with bullous emphysema. METHODS: A series of 95 patients undergoing excision of bullous lung tissue was reviewed to determine the incidence and long term outcome of occult carcinoma present in the resected material. RESULTS: Four patients (4.2%) had peripheral foci of large cell carcinoma in the resection specimen (three bullectomies and one lobectomy). CONCLUSIONS: Resected bullous lung tissue should be carefully examined for areas of bronchogenic carcinoma. The results of incidental complete excision are favourable.
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- Aronberg D. J., Sagel S. S., LeFrak S., Kuhn C., Susman N. Lung carcinoma associated with bullous lung disease in young men. AJR Am J Roentgenol. 1980 Feb;134(2):249–252. doi: 10.2214/ajr.134.2.249. [DOI] [PubMed] [Google Scholar]
- Enarson D. A., Vedal S., Schulzer M., Dybuncio A., Chan-Yeung M. Asthma, asthmalike symptoms, chronic bronchitis, and the degree of bronchial hyperresponsiveness in epidemiologic surveys. Am Rev Respir Dis. 1987 Sep;136(3):613–617. doi: 10.1164/ajrccm/136.3.613. [DOI] [PubMed] [Google Scholar]
- Freant L. J., Joseph W. L., Adkins P. C. Scar carcinoma of the lung. Fact or fantasy? Ann Thorac Surg. 1974 Jun;17(6):531–537. doi: 10.1016/s0003-4975(10)65693-7. [DOI] [PubMed] [Google Scholar]
- Goldstein M. J., Snider G. L., Liberson M., Poske R. M. Bronchogenic carcinoma and giant bullous disease. Am Rev Respir Dis. 1968 Jun;97(6):1062–1070. doi: 10.1164/arrd.1968.97.6P1.1062. [DOI] [PubMed] [Google Scholar]
- Hyndman S. J., Williams D. R., Merrill S. L., Lipscombe J. M., Palmer C. R. Rates of admission to hospital for asthma. BMJ. 1994 Jun 18;308(6944):1596–1600. doi: 10.1136/bmj.308.6944.1596. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Johnson K. T., Funahashi A. Severe bullous emphysema and contralateral bronchogenic carcinoma. Successful management with staged bilateral thoracotomy. Wis Med J. 1985 Nov;84(11):11–14. [PubMed] [Google Scholar]
- Lange P., Nyboe J., Appleyard M., Jensen G., Schnohr P. Ventilatory function and chronic mucus hypersecretion as predictors of death from lung cancer. Am Rev Respir Dis. 1990 Mar;141(3):613–617. doi: 10.1164/ajrccm/141.3.613. [DOI] [PubMed] [Google Scholar]
- Markowe H. L., Bulpitt C. J., Shipley M. J., Rose G., Crombie D. L., Fleming D. M. Prognosis in adult asthma: a national study. Br Med J (Clin Res Ed) 1987 Oct 17;295(6604):949–952. doi: 10.1136/bmj.295.6604.949. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Morris R. D., Munasinghe R. L. Geographic variability in hospital admission rates for respiratory disease among the elderly in the United States. Chest. 1994 Oct;106(4):1172–1181. doi: 10.1378/chest.106.4.1172. [DOI] [PubMed] [Google Scholar]
- Nickoladze G. D. Bullae and lung cancer. J Thorac Cardiovasc Surg. 1993 Jul;106(1):186–186. [PubMed] [Google Scholar]
- RAEBURN B., SPENCER H. Lung scar cancers. Br J Tuberc Dis Chest. 1957 Jul;51(3):237–245. doi: 10.1016/s0366-0869(57)80080-x. [DOI] [PubMed] [Google Scholar]
- Scannell J. G. "Bleb" carcinoma of the lung. J Thorac Cardiovasc Surg. 1980 Dec;80(6):904–908. [PubMed] [Google Scholar]
- Shah S. S., Goldstraw P. Surgical treatment of bullous emphysema: experience with the Brompton technique. Ann Thorac Surg. 1994 Nov;58(5):1452–1456. doi: 10.1016/0003-4975(94)91934-8. [DOI] [PubMed] [Google Scholar]
- Skobeloff E. M., Spivey W. H., St Clair S. S., Schoffstall J. M. The influence of age and sex on asthma admissions. JAMA. 1992 Dec 23;268(24):3437–3440. [PubMed] [Google Scholar]
- Stoloff I. L., Kanofsky P., Magilner L. The risk of lung cancer in males with bullous disease of the lung. Arch Environ Health. 1971 Jan;22(1):163–167. doi: 10.1080/00039896.1971.10665827. [DOI] [PubMed] [Google Scholar]
- YOKOO H., SUCKOW E. E. Peripheral lung cancers arising in scars. Cancer. 1961 Nov-Dec;14:1205–1215. doi: 10.1002/1097-0142(196111/12)14:6<1205::aid-cncr2820140610>3.0.co;2-2. [DOI] [PubMed] [Google Scholar]