Skip to main content
PMC home page
Thorax logoLink to Thorax
. 1997 Jun;52(6):569–574. doi: 10.1136/thx.52.6.569

"Ultimate activation" of eosinophils in vivo: lysis and release of clusters of free eosinophil granules (Cfegs)

C G Persson, J S Erjefalt
PMCID: PMC1758581  PMID: 9227728

Full Text

The Full Text of this article is available as a PDF (203.2 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abu-Ghazaleh R. I., Fujisawa T., Mestecky J., Kyle R. A., Gleich G. J. IgA-induced eosinophil degranulation. J Immunol. 1989 Apr 1;142(7):2393–2400. [PubMed] [Google Scholar]
  2. Beasley R., Roche W. R., Roberts J. A., Holgate S. T. Cellular events in the bronchi in mild asthma and after bronchial provocation. Am Rev Respir Dis. 1989 Mar;139(3):806–817. doi: 10.1164/ajrccm/139.3.806. [DOI] [PubMed] [Google Scholar]
  3. Dvorak A. M., Furitsu T., Letourneau L., Ishizaka T., Ackerman S. J. Mature eosinophils stimulated to develop in human cord blood mononuclear cell cultures supplemented with recombinant human interleukin-5. Part I. Piecemeal degranulation of specific granules and distribution of Charcot-Leyden crystal protein. Am J Pathol. 1991 Jan;138(1):69–82. [PMC free article] [PubMed] [Google Scholar]
  4. Dvorak A. M., Mihm M. C., Jr, Osage J. E., Kwan T. H., Austen K. F., Wintroub B. U. Bullous pemphigoid, an ultrastructural study of the inflammatory response: eosinophil, basophil and mast cell granule changes in multiple biopsies from one patient. J Invest Dermatol. 1982 Feb;78(2):91–101. doi: 10.1111/1523-1747.ep12505711. [DOI] [PubMed] [Google Scholar]
  5. Dvorak A. M. Similarities in the ultrastructural morphology and developmental and secretory mechanisms of human basophils and eosinophils. J Allergy Clin Immunol. 1994 Dec;94(6 Pt 2):1103–1134. doi: 10.1016/0091-6749(94)90320-4. [DOI] [PubMed] [Google Scholar]
  6. Erjefält J. S., Sundler F., Persson C. G. Eosinophils, neutrophils, and venular gaps in the airway mucosa at epithelial removal-restitution. Am J Respir Crit Care Med. 1996 May;153(5):1666–1674. doi: 10.1164/ajrccm.153.5.8630618. [DOI] [PubMed] [Google Scholar]
  7. Filley W. V., Holley K. E., Kephart G. M., Gleich G. J. Identification by immunofluorescence of eosinophil granule major basic protein in lung tissues of patients with bronchial asthma. Lancet. 1982 Jul 3;2(8288):11–16. doi: 10.1016/s0140-6736(82)91152-7. [DOI] [PubMed] [Google Scholar]
  8. Gonzalez E. B., Swedo J. L., Rajaraman S., Daniels J. C., Grant J. A. Ultrastructural and immunohistochemical evidence for release of eosinophilic granules in vivo: cytotoxic potential in chronic eosinophilic pneumonia. J Allergy Clin Immunol. 1987 May;79(5):755–762. doi: 10.1016/0091-6749(87)90207-7. [DOI] [PubMed] [Google Scholar]
  9. Griffiths-Johnson D. A., Collins P. D., Rossi A. G., Jose P. J., Williams T. J. The chemokine, eotaxin, activates guinea-pig eosinophils in vitro and causes their accumulation into the lung in vivo. Biochem Biophys Res Commun. 1993 Dec 30;197(3):1167–1172. doi: 10.1006/bbrc.1993.2599. [DOI] [PubMed] [Google Scholar]
  10. Gundel R. H., Gerritsen M. E., Gleich G. J., Wegner C. D. Repeated antigen inhalation results in a prolonged airway eosinophilia and airway hyperresponsiveness in primates. J Appl Physiol (1985) 1990 Feb;68(2):779–786. doi: 10.1152/jappl.1990.68.2.779. [DOI] [PubMed] [Google Scholar]
  11. Janin A., Torpier G., Courtin P., Capron M., Prin L., Tonnel A. B., Hatron P. Y., Gosselin B. Segregation of eosinophil proteins in alveolar macrophage compartments in chronic eosinophilic pneumonia. Thorax. 1993 Jan;48(1):57–62. doi: 10.1136/thx.48.1.57. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Jeffery P. K., Godfrey R. W., Adelroth E., Nelson F., Rogers A., Johansson S. A. Effects of treatment on airway inflammation and thickening of basement membrane reticular collagen in asthma. A quantitative light and electron microscopic study. Am Rev Respir Dis. 1992 Apr;145(4 Pt 1):890–899. doi: 10.1164/ajrccm/145.4_Pt_1.890. [DOI] [PubMed] [Google Scholar]
  13. Laitinen L. A., Laitinen A., Haahtela T. Airway mucosal inflammation even in patients with newly diagnosed asthma. Am Rev Respir Dis. 1993 Mar;147(3):697–704. doi: 10.1164/ajrccm/147.3.697. [DOI] [PubMed] [Google Scholar]
  14. Leiferman K. M., Fujisawa T., Gray B. H., Gleich G. J. Extracellular deposition of eosinophil and neutrophil granule proteins in the IgE-mediated cutaneous late phase reaction. Lab Invest. 1990 May;62(5):579–589. [PubMed] [Google Scholar]
  15. Majno G., Joris I. Apoptosis, oncosis, and necrosis. An overview of cell death. Am J Pathol. 1995 Jan;146(1):3–15. [PMC free article] [PubMed] [Google Scholar]
  16. Martin L. B., Kita H., Leiferman K. M., Gleich G. J. Eosinophils in allergy: role in disease, degranulation, and cytokines. Int Arch Allergy Immunol. 1996 Mar;109(3):207–215. doi: 10.1159/000237239. [DOI] [PubMed] [Google Scholar]
  17. McEvoy J. D., Donald K. J., Edwards R. L. Immunoglobulin levels and electron microscopy in eosinophilic pneumonia. Am J Med. 1978 Mar;64(3):529–536. doi: 10.1016/0002-9343(78)90248-6. [DOI] [PubMed] [Google Scholar]
  18. Ohashi Y., Motojima S., Fukuda T., Makino S. Airway hyperresponsiveness, increased intracellular spaces of bronchial epithelium, and increased infiltration of eosinophils and lymphocytes in bronchial mucosa in asthma. Am Rev Respir Dis. 1992 Jun;145(6):1469–1476. doi: 10.1164/ajrccm/145.6.1469. [DOI] [PubMed] [Google Scholar]
  19. Persson C. G. In vivo veritas: the continuing importance of discoveries in complex biosystems. Thorax. 1996 Apr;51(4):441–443. doi: 10.1136/thx.51.4.441. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Pimenta P. F., Dos Santos M. A., De Souza W. Fine structure and cytochemistry of the interaction between Leishmania mexicana amazonensis and rat neutrophils and eosinophils. J Submicrosc Cytol. 1987 Jul;19(3):387–395. [PubMed] [Google Scholar]
  21. Seiler G., Westerman R. A., Wilson J. A. The role of specific eosinophil granules in eosinophil-induced experimental encephalitis. Neurology. 1969 May;19(5):478–488. doi: 10.1212/wnl.19.5.478. [DOI] [PubMed] [Google Scholar]
  22. Villalta F., Pankratz H. S., Kierszenbaum F. Extracellular killing of Trypanosoma cruzi amastigotes by human eosinophils. J Protozool. 1987 Aug;34(3):285–290. doi: 10.1111/j.1550-7408.1987.tb03176.x. [DOI] [PubMed] [Google Scholar]
  23. Weiler C. R., Kita H., Hukee M., Gleich G. J. Eosinophil viability during immunoglobulin-induced degranulation. J Leukoc Biol. 1996 Oct;60(4):493–501. doi: 10.1002/jlb.60.4.493. [DOI] [PubMed] [Google Scholar]
  24. Weller P. F. The immunobiology of eosinophils. N Engl J Med. 1991 Apr 18;324(16):1110–1118. doi: 10.1056/NEJM199104183241607. [DOI] [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES