Abstract
A chemical plant operator developed asthma five months after starting work in an isothiazolinone manufacturing plant. He described symptoms of late asthmatic reactions after work with isothiazolinone. Airway responsiveness to methacholine improved tenfold when he was removed from the plant for 18 days. A workplace challenge study then resulted in a deterioration in airway responsiveness to its earlier level and in progressive falls in forced expiratory volume in one second (FEV1) over three days at work compared with control days, indicating statistically significant late asthmatic reactions of increasing severity.
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- Beach J. R., Young C. L., Avery A. J., Stenton S. C., Dennis J. H., Walters E. H., Hendrick D. J. Measurement of airway responsiveness to methacholine: relative importance of the precision of drug delivery and the method of assessing response. Thorax. 1993 Mar;48(3):239–243. doi: 10.1136/thx.48.3.239. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Berenguer J., Solera J., Diaz M. D., Moreno S., López-Herce J. A., Bouza E. Listeriosis in patients infected with human immunodeficiency virus. Rev Infect Dis. 1991 Jan-Feb;13(1):115–119. doi: 10.1093/clinids/13.1.115. [DOI] [PubMed] [Google Scholar]
- Decker C. F., Simon G. L., DiGioia R. A., Tuazon C. U. Listeria monocytogenes infections in patients with AIDS: report of five cases and review. Rev Infect Dis. 1991 May-Jun;13(3):413–417. doi: 10.1093/clinids/13.3.413. [DOI] [PubMed] [Google Scholar]
- Domingo P., Serra J., Sambeat M. A., Ausina V. Pneumonia due to Listeria monocytogenes. Clin Infect Dis. 1992 Mar;14(3):787–789. doi: 10.1093/clinids/14.3.787. [DOI] [PubMed] [Google Scholar]
- Gannon P. F., Bright P., Campbell M., O'Hickey S. P., Burge P. S. Occupational asthma due to glutaraldehyde and formaldehyde in endoscopy and x ray departments. Thorax. 1995 Feb;50(2):156–159. doi: 10.1136/thx.50.2.156. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jones E. M., MacGowan A. P. Antimicrobial chemotherapy of human infection due to Listeria monocytogenes. Eur J Clin Microbiol Infect Dis. 1995 Mar;14(3):165–175. doi: 10.1007/BF02310351. [DOI] [PubMed] [Google Scholar]
- Jurado R. L., Farley M. M., Pereira E., Harvey R. C., Schuchat A., Wenger J. D., Stephens D. S. Increased risk of meningitis and bacteremia due to Listeria monocytogenes in patients with human immunodeficiency virus infection. Clin Infect Dis. 1993 Aug;17(2):224–227. doi: 10.1093/clinids/17.2.224. [DOI] [PubMed] [Google Scholar]
- Malo J. L., Cartier A., Desjardins A. Occupational asthma caused by dry metabisulphite. Thorax. 1995 May;50(5):585–589. doi: 10.1136/thx.50.5.585. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mascola L., Lieb L., Chiu J., Fannin S. L., Linnan M. J. Listeriosis: an uncommon opportunistic infection in patients with acquired immunodeficiency syndrome. A report of five cases and a review of the literature. Am J Med. 1988 Jan;84(1):162–164. doi: 10.1016/0002-9343(88)90027-7. [DOI] [PubMed] [Google Scholar]
- Simpson J. F., Leddy J. P., Hare J. D. Listeriosis complicating lymphoma. Report of four cases and interpretive review of pathogenetic factors. Am J Med. 1967 Jul;43(1):39–49. doi: 10.1016/0002-9343(67)90147-7. [DOI] [PubMed] [Google Scholar]
- Stenton S. C., Avery A. J., Walters E. H., Hendrick D. J. Statistical approaches to the identification of late asthmatic reactions. Eur Respir J. 1994 Apr;7(4):806–812. doi: 10.1183/09031936.94.07040806. [DOI] [PubMed] [Google Scholar]
- Valsecchi R., Leghissa P., Piazzolla S., Cainelli T., Seghizzi P. Occupational dermatitis from isothiazolinones in the nylon production. Dermatology. 1993;187(2):109–111. doi: 10.1159/000247217. [DOI] [PubMed] [Google Scholar]