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. 1988 Sep;32(9):1336–1340. doi: 10.1128/aac.32.9.1336

In vitro activity of DR-3355, an optically active ofloxacin.

T Une 1, T Fujimoto 1, K Sato 1, Y Osada 1
PMCID: PMC175863  PMID: 3195996

Abstract

DR-3355, the S-(-)-isomer of ofloxacin, was generally twice as potent as ofloxacin against a variety of gram-positive and gram-negative pathogens, and its action was bactericidal. The compound was characterized by having the highest level of activity against staphylococci, Bacteroides fragilis, and Peptococcus spp. of the fluorinated quinolones tested, including ofloxacin, ciprofloxacin, fleroxacin, and NY-198. The activity of DR-3355 was not affected by different media, inoculum size, or human serum, but decreased under acidic conditions at pH 5.0 or in human urine.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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