Skip to main content
PMC home page
Thorax logoLink to Thorax
. 1998 Jan;53(1):21–27. doi: 10.1136/thx.53.1.21

Expression of growth factors and remodelling of the airway wall in bronchial asthma

M Hoshino, Y Nakamura, J J Sim
PMCID: PMC1758699  PMID: 9577517

Full Text

The Full Text of this article is available as a PDF (165.1 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aston C., Jagirdar J., Lee T. C., Hur T., Hintz R. L., Rom W. N. Enhanced insulin-like growth factor molecules in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 1995 May;151(5):1597–1603. doi: 10.1164/ajrccm.151.5.7537587. [DOI] [PubMed] [Google Scholar]
  2. Aston C., Jagirdar J., Lee T. C., Hur T., Hintz R. L., Rom W. N. Enhanced insulin-like growth factor molecules in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 1995 May;151(5):1597–1603. doi: 10.1164/ajrccm.151.5.7537587. [DOI] [PubMed] [Google Scholar]
  3. Aubert J. D., Dalal B. I., Bai T. R., Roberts C. R., Hayashi S., Hogg J. C. Transforming growth factor beta 1 gene expression in human airways. Thorax. 1994 Mar;49(3):225–232. doi: 10.1136/thx.49.3.225. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bland J. M., Altman D. G. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet. 1986 Feb 8;1(8476):307–310. [PubMed] [Google Scholar]
  5. Bousquet J., Chanez P., Lacoste J. Y., Barnéon G., Ghavanian N., Enander I., Venge P., Ahlstedt S., Simony-Lafontaine J., Godard P. Eosinophilic inflammation in asthma. N Engl J Med. 1990 Oct 11;323(15):1033–1039. doi: 10.1056/NEJM199010113231505. [DOI] [PubMed] [Google Scholar]
  6. Bousquet J., Chanez P., Lacoste J. Y., White R., Vic P., Godard P., Michel F. B. Asthma: a disease remodeling the airways. Allergy. 1992 Feb;47(1):3–11. doi: 10.1111/j.1398-9995.1992.tb02242.x. [DOI] [PubMed] [Google Scholar]
  7. Brewster C. E., Howarth P. H., Djukanovic R., Wilson J., Holgate S. T., Roche W. R. Myofibroblasts and subepithelial fibrosis in bronchial asthma. Am J Respir Cell Mol Biol. 1990 Nov;3(5):507–511. doi: 10.1165/ajrcmb/3.5.507. [DOI] [PubMed] [Google Scholar]
  8. Cambrey A. D., Kwon O. J., Gray A. J., Harrison N. K., Yacoub M., Barnes P. J., Laurent G. J., Chung K. F. Insulin-like growth factor I is a major fibroblast mitogen produced by primary cultures of human airway epithelial cells. Clin Sci (Lond) 1995 Dec;89(6):611–617. doi: 10.1042/cs0890611. [DOI] [PubMed] [Google Scholar]
  9. Chetta A., Foresi A., Del Donno M., Consigli G. F., Bertorelli G., Pesci A., Barbee R. A., Olivieri D. Bronchial responsiveness to distilled water and methacholine and its relationship to inflammation and remodeling of the airways in asthma. Am J Respir Crit Care Med. 1996 Mar;153(3):910–917. doi: 10.1164/ajrccm.153.3.8630572. [DOI] [PubMed] [Google Scholar]
  10. Clemmons D. R., Van Wyk J. J. Evidence for a functional role of endogenously produced somatomedinlike peptides in the regulation of DNA synthesis in cultured human fibroblasts and porcine smooth muscle cells. J Clin Invest. 1985 Jun;75(6):1914–1918. doi: 10.1172/JCI111906. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Cutz E., Levison H., Cooper D. M. Ultrastructure of airways in children with asthma. Histopathology. 1978 Nov;2(6):407–421. doi: 10.1111/j.1365-2559.1978.tb01735.x. [DOI] [PubMed] [Google Scholar]
  12. DUNNILL M. S. The pathology of asthma, with special reference to changes in the bronchial mucosa. J Clin Pathol. 1960 Jan;13:27–33. doi: 10.1136/jcp.13.1.27. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Flanders K. C., Thompson N. L., Cissel D. S., Van Obberghen-Schilling E., Baker C. C., Kass M. E., Ellingsworth L. R., Roberts A. B., Sporn M. B. Transforming growth factor-beta 1: histochemical localization with antibodies to different epitopes. J Cell Biol. 1989 Feb;108(2):653–660. doi: 10.1083/jcb.108.2.653. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. HOUSTON J. C., DE NAVASQUEZ S., TROUNCE J. R. A clinical and pathological study of fatal cases of status asthmaticus. Thorax. 1953 Sep;8(3):207–213. doi: 10.1136/thx.8.3.207. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Han V. K., D'Ercole A. J., Lund P. K. Cellular localization of somatomedin (insulin-like growth factor) messenger RNA in the human fetus. Science. 1987 Apr 10;236(4798):193–197. doi: 10.1126/science.3563497. [DOI] [PubMed] [Google Scholar]
  16. Hertz M. I., Henke C. A., Nakhleh R. E., Harmon K. R., Marinelli W. A., Fox J. M., Kubo S. H., Shumway S. J., Bolman R. M., 3rd, Bitterman P. B. Obliterative bronchiolitis after lung transplantation: a fibroproliferative disorder associated with platelet-derived growth factor. Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10385–10389. doi: 10.1073/pnas.89.21.10385. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Hill D. J., Strain A. J., Elstow S. F., Swenne I., Milner R. D. Bi-functional action of transforming growth factor-beta on DNA synthesis in early passage human fetal fibroblasts. J Cell Physiol. 1986 Aug;128(2):322–328. doi: 10.1002/jcp.1041280226. [DOI] [PubMed] [Google Scholar]
  18. Ignotz R. A., Heino J., Massagué J. Regulation of cell adhesion receptors by transforming growth factor-beta. Regulation of vitronectin receptor and LFA-1. J Biol Chem. 1989 Jan 5;264(1):389–392. [PubMed] [Google Scholar]
  19. Ignotz R. A., Massagué J. Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. J Biol Chem. 1986 Mar 25;261(9):4337–4345. [PubMed] [Google Scholar]
  20. Khalil N., Bereznay O., Sporn M., Greenberg A. H. Macrophage production of transforming growth factor beta and fibroblast collagen synthesis in chronic pulmonary inflammation. J Exp Med. 1989 Sep 1;170(3):727–737. doi: 10.1084/jem.170.3.727. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Koivu J., Myllylä R., Helaakoski T., Pihlajaniemi T., Tasanen K., Kivirikko K. I. A single polypeptide acts both as the beta subunit of prolyl 4-hydroxylase and as a protein disulfide-isomerase. J Biol Chem. 1987 May 15;262(14):6447–6449. [PubMed] [Google Scholar]
  22. Martinet Y., Rom W. N., Grotendorst G. R., Martin G. R., Crystal R. G. Exaggerated spontaneous release of platelet-derived growth factor by alveolar macrophages from patients with idiopathic pulmonary fibrosis. N Engl J Med. 1987 Jul 23;317(4):202–209. doi: 10.1056/NEJM198707233170404. [DOI] [PubMed] [Google Scholar]
  23. Molina C., Brun J., Coulet M., Betail G., Delage J. Immunopathology of the bronchial mucosa in 'late onset' asthma. Clin Allergy. 1977 Mar;7(2):137–145. doi: 10.1111/j.1365-2222.1977.tb01434.x. [DOI] [PubMed] [Google Scholar]
  24. Motojima S., Frigas E., Loegering D. A., Gleich G. J. Toxicity of eosinophil cationic proteins for guinea pig tracheal epithelium in vitro. Am Rev Respir Dis. 1989 Mar;139(3):801–805. doi: 10.1164/ajrccm/139.3.801. [DOI] [PubMed] [Google Scholar]
  25. Nakamura Y., Tate L., Ertl R. F., Kawamoto M., Mio T., Adachi Y., Romberger D. J., Koizumi S., Gossman G., Robbins R. A. Bronchial epithelial cells regulate fibroblast proliferation. Am J Physiol. 1995 Sep;269(3 Pt 1):L377–L387. doi: 10.1152/ajplung.1995.269.3.L377. [DOI] [PubMed] [Google Scholar]
  26. Roberts C. J., Birkenmeier T. M., McQuillan J. J., Akiyama S. K., Yamada S. S., Chen W. T., Yamada K. M., McDonald J. A. Transforming growth factor beta stimulates the expression of fibronectin and of both subunits of the human fibronectin receptor by cultured human lung fibroblasts. J Biol Chem. 1988 Apr 5;263(10):4586–4592. [PubMed] [Google Scholar]
  27. Roche W. R., Beasley R., Williams J. H., Holgate S. T. Subepithelial fibrosis in the bronchi of asthmatics. Lancet. 1989 Mar 11;1(8637):520–524. doi: 10.1016/s0140-6736(89)90067-6. [DOI] [PubMed] [Google Scholar]
  28. Svoboda M. E., Van Wyk J. J., Klapper D. G., Fellows R. E., Grissom F. E., Schlueter R. J. Purification of somatomedin-C from human plasma: chemical and biological properties, partial sequence analysis, and relationship to other somatomedins. Biochemistry. 1980 Feb 19;19(4):790–797. doi: 10.1021/bi00545a027. [DOI] [PubMed] [Google Scholar]
  29. Takishima T., Hida W., Sasaki H., Suzuki S., Sasaki T. Direct-writing recorder of the dose-response curves of the airway to methacholine. Clinical application. Chest. 1981 Nov;80(5):600–606. doi: 10.1378/chest.80.5.600. [DOI] [PubMed] [Google Scholar]
  30. Wiggs B. R., Bosken C., Paré P. D., James A., Hogg J. C. A model of airway narrowing in asthma and in chronic obstructive pulmonary disease. Am Rev Respir Dis. 1992 Jun;145(6):1251–1258. doi: 10.1164/ajrccm/145.6.1251. [DOI] [PubMed] [Google Scholar]
  31. Yamakage A., Kikuchi K., Smith E. A., LeRoy E. C., Trojanowska M. Selective upregulation of platelet-derived growth factor alpha receptors by transforming growth factor beta in scleroderma fibroblasts. J Exp Med. 1992 May 1;175(5):1227–1234. doi: 10.1084/jem.175.5.1227. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES