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. 1988 Sep;32(9):1416–1420. doi: 10.1128/aac.32.9.1416

Transposon-mediated amikacin resistance in Klebsiella pneumoniae.

M E Tolmasky 1, R M Chamorro 1, J H Crosa 1, P M Marini 1
PMCID: PMC175879  PMID: 2848445

Abstract

A multiresistant Klebsiella pneumoniae strain isolated from neonates in Mendoza, Argentina, harbored a 48-kilobase-pair (kbp) plasmid, pMET1, with genetic determinants for resistance to amikacin and also ampicillin, kanamycin, streptomycin, and tobramycin. This plasmid was compared with pJHCMW1, a previously isolated 11-kbp plasmid carrying transposon Tn1331, which encodes resistance to amikacin, as well as ampicillin, kanamycin, streptomycin, and tobramycin, and which was originally present in a K. pneumoniae strain that caused an outbreak in a hospital in Buenos Aires, Argentina. The comparison demonstrated that the replication regions of the two plasmids are unrelated. However, in pMET1 an 11-kbp transposition element, Tn1331.2, was identified; it was closely related to Tn1331, with the difference that a 3-kbp BamHI DNA fragment carrying the aminoglycoside resistance genes was duplicated in tandem.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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