Skip to main content
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1988 Oct;32(10):1586–1587. doi: 10.1128/aac.32.10.1586

Activities of compound G2 isolated from alfalfa roots against dermatophytes.

R Evron 1, I Polacheck 1, M Guizie 1, M Levy 1, U Zehavi 1
PMCID: PMC175924  PMID: 3190186

Abstract

An antimycotic agent, compound G2, isolated from alfalfa roots exhibited considerable activity against the six most common dermatophytes. MICs in agar and broth dilutions ranged from 10 to 30 micrograms/ml and from 2 to 10 micrograms/ml, respectively. G2 was fungicidal at 5 to 22 micrograms/ml. Structure and toxicity relations are discussed.

Full text

PDF
1586

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Assa Y., Gestetner B., Chet I., Henis Y. Fungistatic activity of lucerne saponins and digitonin as related to sterols. Life Sci II. 1972 Jul 8;11(13):637–647. doi: 10.1016/0024-3205(72)90012-4. [DOI] [PubMed] [Google Scholar]
  2. Bezjak V. Standardization of a hyphal inoculum of aspergilli for amphotericin B susceptibility testing. J Clin Microbiol. 1985 Apr;21(4):509–512. doi: 10.1128/jcm.21.4.509-512.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Hiller K., Paulick A., Friedrich E. Zur Hemmwirkung von Polemoniumsaponin gegenüber Pilzen. Pharmazie. 1981;36(2):133–134. [PubMed] [Google Scholar]
  4. Kusunoki T., Harada S. Comparison of the in vitro antifungal activities of clotrimazole, miconazole, econazole and exalamide against clinical isolates of dermatophytes. J Dermatol. 1984 Jun;11(3):277–281. doi: 10.1111/j.1346-8138.1984.tb01477.x. [DOI] [PubMed] [Google Scholar]
  5. Polacheck I., Zehavi U., Naim M., Levy M., Evron R. Activity of compound G2 isolated from alfalfa roots against medically important yeasts. Antimicrob Agents Chemother. 1986 Aug;30(2):290–294. doi: 10.1128/aac.30.2.290. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Polacheck I., Zehavi U., Naim M., Levy M., Evron R. The susceptibility of Cryptococcus neoformans to an antimycotic agent (G2) from alfalfa. Zentralbl Bakteriol Mikrobiol Hyg A. 1986 Jul;261(4):481–486. doi: 10.1016/s0176-6724(86)80080-3. [DOI] [PubMed] [Google Scholar]
  7. Polak A. Antifungal activity of four antifungal drugs in the cutaneous retention time test. Sabouraudia. 1984;22(6):501–503. doi: 10.1080/00362178485380781. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES