Abstract
The in vitro activities of five new quinoline-carboxylic acids against 2 reference strains and 45 clinical isolates of Chlamydia trachomatis of genital origin were compared with the activities of minocycline and doxycycline. Ofloxacin was the third most active agent (after the two tetracyclines), followed by ciprofloxacin, NY-198, and AM-833.
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Selected References
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- Aznar J., Caballero M. C., Lozano M. C., de Miguel C., Palomares J. C., Perea E. J. Activities of new quinoline derivatives against genital pathogens. Antimicrob Agents Chemother. 1985 Jan;27(1):76–78. doi: 10.1128/aac.27.1.76. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bailey J. M., Heppleston C., Richmond S. J. Comparison of the in vitro activities of ofloxacin and tetracycline against Chlamydia trachomatis as assessed by indirect immunofluorescence. Antimicrob Agents Chemother. 1984 Jul;26(1):13–16. doi: 10.1128/aac.26.1.13. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bowie W. R., Shaw C. E., Chan D. G., Boyd J., Black W. A. In vitro activity of difloxacin hydrochloride (A-56619), A-56620, and cefixime (CL 284,635; FK 027) against selected genital pathogens. Antimicrob Agents Chemother. 1986 Oct;30(4):590–593. doi: 10.1128/aac.30.4.590. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bowie W. R., Willetts V., Sibau L. Failure of norfloxacin to eradicate Chlamydia trachomatis in nongonococcal urethritis. Antimicrob Agents Chemother. 1986 Oct;30(4):594–597. doi: 10.1128/aac.30.4.594. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Evans R. T., Taylor-Robinson D. Comparison of various McCoy cell treatment procedures used for detection of Chlamydia trachomatis. J Clin Microbiol. 1979 Aug;10(2):198–201. doi: 10.1128/jcm.10.2.198-201.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fong I. W., Linton W., Simbul M., Thorup R., McLaughlin B., Rahm V., Quinn P. A. Treatment of nongonococcal urethritis with ciprofloxacin. Am J Med. 1987 Apr 27;82(4A):311–316. [PubMed] [Google Scholar]
- Fransen L., Avonts D., Piot P. Treatment of genital chlamydial infection with ofloxacin. Infection. 1986;14 (Suppl 4):S318–S320. doi: 10.1007/BF01661307. [DOI] [PubMed] [Google Scholar]
- Heessen F. W., Muytjens H. L. In vitro activities of ciprofloxacin, norfloxacin, pipemidic acid, cinoxacin, and nalidixic acid against Chlamydia trachomatis. Antimicrob Agents Chemother. 1984 Jan;25(1):123–124. doi: 10.1128/aac.25.1.123. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Heppleston C., Richmond S., Bailey J. Antichlamydial activity of quinolone carboxylic acids. J Antimicrob Chemother. 1985 May;15(5):645–647. doi: 10.1093/jac/15.5.645. [DOI] [PubMed] [Google Scholar]
- Kumada T., Neu H. C. In-vitro activity of ofloxacin, a quinolone carboxylic acid compared to other quinolones and other antimicrobial agents. J Antimicrob Chemother. 1985 Nov;16(5):563–574. doi: 10.1093/jac/16.5.563. [DOI] [PubMed] [Google Scholar]
- Liebowitz L. D., Saunders J., Fehler G., Ballard R. C., Koornhof H. J. In vitro activity of A-56619 (difloxacin), A-56620, and other new quinolone antimicrobial agents against genital pathogens. Antimicrob Agents Chemother. 1986 Dec;30(6):948–950. doi: 10.1128/aac.30.6.948. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Oriel J. D., Ridgway G. L. Comparison of tetracycline and minocycline in the treatment of non-gonococcal urethritis. Br J Vener Dis. 1983 Aug;59(4):245–248. doi: 10.1136/sti.59.4.245. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Peeters M., Van Dyck E., Piot P. In vitro activities of the spectinomycin analog U-63366 and four quinolone derivatives against Neisseria gonorrhoeae. Antimicrob Agents Chemother. 1984 Oct;26(4):608–609. doi: 10.1128/aac.26.4.608. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ridgway G. L., Mumtaz G., Gabriel F. G., Oriel J. D. The activity of ciprofloxacin and other 4-quinolones against Chlamydia trachomatis and Mycoplasmas in vitro. Eur J Clin Microbiol. 1984 Aug;3(4):344–346. doi: 10.1007/BF01977491. [DOI] [PubMed] [Google Scholar]
- Sato K., Matsuura Y., Inoue M., Une T., Osada Y., Ogawa H., Mitsuhashi S. In vitro and in vivo activity of DL-8280, a new oxazine derivative. Antimicrob Agents Chemother. 1982 Oct;22(4):548–553. doi: 10.1128/aac.22.4.548. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stamm W. E., Suchland R. Antimicrobial activity of U-70138F (paldimycin), roxithromycin (RU 965), and ofloxacin (ORF 18489) against Chlamydia trachomatis in cell culture. Antimicrob Agents Chemother. 1986 Nov;30(5):806–807. doi: 10.1128/aac.30.5.806. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tegelberg-Stassen M. J., van der Hoek J. C., Mooi L., Wagenvoort J. H., van Joost T., Michel M. F., Stolz E. Treatment of uncomplicated gonococcal urethritis in men with two dosages of ciprofloxacin. Eur J Clin Microbiol. 1986 Apr;5(2):244–246. doi: 10.1007/BF02013999. [DOI] [PubMed] [Google Scholar]
- Wise R., Andrews J. M., Edwards L. J. In vitro activity of Bay 09867, a new quinoline derivative, compared with those of other antimicrobial agents. Antimicrob Agents Chemother. 1983 Apr;23(4):559–564. doi: 10.1128/aac.23.4.559. [DOI] [PMC free article] [PubMed] [Google Scholar]