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. 1988 Nov;32(11):1740–1741. doi: 10.1128/aac.32.11.1740

Evaluation of single-dose ciprofloxacin in the eradication of Neisseria meningitidis from nasopharyngeal carriers.

D L Dworzack 1, C C Sanders 1, E A Horowitz 1, J M Allais 1, M Sookpranee 1, W E Sanders Jr 1, F M Ferraro 1
PMCID: PMC175963  PMID: 3252755

Abstract

The ability of a single oral 750-mg dose of ciprofloxacin to eradicate Neisseria meningitidis from persistent nasopharyngeal carriers was prospectively evaluated in a placebo-controlled, randomized, double-blinded study. Cultures of specimens taken from all 23 ciprofloxacin-dosed subjects 1 day postdose were negative; cultures from 96% of these subjects were negative at 7 and 21 days postdose, including a specimen from a subject colonized with a minocycline-resistant strain. Of 22 placebo recipients, 20 (91%) remained culture positive. Single-dose ciprofloxacin appears efficacious for meningococcal prophylaxis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Artenstein M. S., Lamson T. H., Evans J. R. Attempted prophylaxis against meningococcal infection using intramuscular penicillin. Mil Med. 1967 Dec;132(12):1009–1011. [PubMed] [Google Scholar]
  2. BRISTOW W. M., VANPEENEN P. F., VOLK R. EPIDEMIC MENINGITIS IN NAVAL RECRUITS. Am J Public Health Nations Health. 1965 Jul;55:1039–1045. doi: 10.2105/ajph.55.7.1039. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Chin N. X., Neu H. C. Ciprofloxacin, a quinolone carboxylic acid compound active against aerobic and anaerobic bacteria. Antimicrob Agents Chemother. 1984 Mar;25(3):319–326. doi: 10.1128/aac.25.3.319. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cooper E. R., Ellison R. T., 3rd, Smith G. S., Blaser M. J., Reller L. B., Paisley J. W. Rifampin-resistant meningococcal disease in a contact patient given prophylactic rifampin. J Pediatr. 1986 Jan;108(1):93–96. doi: 10.1016/s0022-3476(86)80776-4. [DOI] [PubMed] [Google Scholar]
  5. Deal W. B., Sanders E. Efficacy of rifampin in treatment of meningococcal carriers. N Engl J Med. 1969 Sep 18;281(12):641–645. doi: 10.1056/NEJM196909182811203. [DOI] [PubMed] [Google Scholar]
  6. Devine L. F., Johnson D. P., Rhode S. L., 3rd, Hagerman C. R., Pierce W. E., Peckinpaugh R. O. Rifampin: effect of two-day treatment on the meningococcal carrier state and the relationship to the levels of drug in sera and saliva. Am J Med Sci. 1971 Feb;261(2):79–83. doi: 10.1097/00000441-197102000-00004. [DOI] [PubMed] [Google Scholar]
  7. Dowd J. M., Blink D., Miller C. H., Frank P. F., Pierce W. E. Antibiotic prophylaxis of carriers of sulfadiazine-resistant meningococci. J Infect Dis. 1966 Oct;116(4):473–480. doi: 10.1093/infdis/116.4.473. [DOI] [PubMed] [Google Scholar]
  8. Gaunt P. N., Lambert B. E. Single dose ciprofloxacin for the eradication of pharyngeal carriage of Neisseria meningitidis. J Antimicrob Chemother. 1988 Apr;21(4):489–496. doi: 10.1093/jac/21.4.489. [DOI] [PubMed] [Google Scholar]
  9. Guttler R. B., Counts G. W., Avent C. K., Beaty H. N. Effect of rifampin and minocycline on meningococcal carrier rates. J Infect Dis. 1971 Aug;124(2):199–205. doi: 10.1093/infdis/124.2.199. [DOI] [PubMed] [Google Scholar]
  10. Jacobson J. A., Daniel B. Vestibular reactions associated with minocycline. Antimicrob Agents Chemother. 1975 Oct;8(4):453–456. doi: 10.1128/aac.8.4.453. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Pugsley M. P., Dworzack D. L., Horowitz E. A., Cuevas T. A., Sanders W. E., Jr, Sanders C. C. Efficacy of ciprofloxacin in the treatment of nasopharyngeal carriers of Neisseria meningitidis. J Infect Dis. 1987 Jul;156(1):211–213. doi: 10.1093/infdis/156.1.211. [DOI] [PubMed] [Google Scholar]
  12. Pugsley M. P., Dworzack D. L., Roccaforte J. S., Sanders C. C., Bakken J. S., Sanders W. E., Jr An open study of the efficacy of a single dose of ciprofloxacin in eliminating the chronic nasopharyngeal carriage of Neisseria meningitidis. J Infect Dis. 1988 Apr;157(4):852–853. doi: 10.1093/infdis/157.4.852. [DOI] [PubMed] [Google Scholar]
  13. Renkonen O. V., Sivonen A., Visakorpi R. Effect of ciprofloxacin on carrier rate of Neisseria meningitidis in army recruits in Finland. Antimicrob Agents Chemother. 1987 Jun;31(6):962–963. doi: 10.1128/aac.31.6.962. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Schwartz B., Al-Tobaiqi A., Al-Ruwais A., Fontaine R. E., A'ashi J., Hightower A. W., Broome C. V., Music S. I. Comparative efficacy of ceftriaxone and rifampicin in eradicating pharyngeal carriage of group A Neisseria meningitidis. Lancet. 1988 Jun 4;1(8597):1239–1242. doi: 10.1016/s0140-6736(88)92069-7. [DOI] [PubMed] [Google Scholar]

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