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. 1990 Jul;34(7):1450–1452. doi: 10.1128/aac.34.7.1450

In vitro inhibition of bacterial DNA gyrase by cinodine, a glycocinnamoylspermidine antibiotic.

M S Osburne 1, W M Maiese 1, M Greenstein 1
PMCID: PMC176000  PMID: 2167040

Abstract

Cinodine, a broad-spectrum glycocinnamoylspermidine antibiotic, binds to DNA and irreversibly inhibits bacterial and phase DNA synthesis. Cinodine was found to inhibit the activity of Micrococcus luteus DNA gyrase in vitro, but it did not inhibit the activities of two other DNA-binding enzymes, namely, topoisomerase I and BamHI. Although we cannot yet conclude that DNA gyrase is an intracellular target of the drug, in vitro inhibition of the enzyme by cinodine appears to be specific.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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