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. 2001 Mar;48(3):435–439. doi: 10.1136/gut.48.3.435

Potential benefits and hazards of physical activity and exercise on the gastrointestinal tract

H PETERS 1, W R DE VRIES 1, G VANBERGE-HENEGOUW 1, L AKKERMANS 1
PMCID: PMC1760153  PMID: 11171839

Abstract

G P VANBERGE-HENEGOUWEN, L M A AKKERMANS

Gastrointestinal Research Unit
Departments of Surgery and Gastroenterology
University Medical Centre Utrecht, Utrecht, The Netherlands


This review describes the current state of knowledge on the hazards of exercise and the potential benefits of physical activity on the gastrointestinal tract. In particular, acute strenuous exercise may provoke gastrointestinal symptoms such as heartburn or diarrhoea. A substantial part (20-50%) of endurance athletes are hampered by these symptoms which may deter them from participation in training and competitive events. Nevertheless, these acute symptoms are transient and do not hamper the athlete's health in the long term. The only exception is repeated gastrointestinal bleeding during training and competition, which in the long term may occasionally lead to iron deficiency and anaemia. In contrast, repetitive exercise periods at a relatively low intensity may have protective effects on the gastrointestinal tract. There is strong evidence that physical activity reduces the risk of colon cancer by up to 50%. Less convincing evidence exists for cholelithiasis and constipation. Physical activity may reduce the risk of diverticulosis, gastrointestinal haemorrhage, and inflammatory bowel disease although this cannot be substantiated firmly. Up to now, underlying mechanisms are poorly understood although decreased gastrointestinal blood flow, neuro-immuno-endocrine alterations, increased gastrointestinal motility, and mechanical bouncing during exercise are postulated. Future research on exercise associated digestive processes should give more insight into the relationship between physical activity and the function of the gastrointestinal tract.



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Figure 1  .

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Putative relationship between the incidence of some gastrointestinal diseases/symptoms and amount of physical activity, ranging from bed rest to marathon running or triathlon. The relationship of other gastrointestinal diseases (that is, diverticulosis, gastrointestinal haemorrhage, inflammatory bowel disease, peptic ulcer disease) is not depicted due to limited evidence.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aldoori W. H., Giovannucci E. L., Rimm E. B., Ascherio A., Stampfer M. J., Colditz G. A., Wing A. L., Trichopoulos D. V., Willett W. C. Prospective study of physical activity and the risk of symptomatic diverticular disease in men. Gut. 1995 Feb;36(2):276–282. doi: 10.1136/gut.36.2.276. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bennion L. J., Grundy S. M. Risk factors for the development of cholelithiasis in man (first of two parts). N Engl J Med. 1978 Nov 23;299(21):1161–1167. doi: 10.1056/NEJM197811232992104. [DOI] [PubMed] [Google Scholar]
  3. Bingham S. A., Cummings J. H. Effect of exercise and physical fitness on large intestinal function. Gastroenterology. 1989 Dec;97(6):1389–1399. doi: 10.1016/0016-5085(89)90381-8. [DOI] [PubMed] [Google Scholar]
  4. Bosenberg A. T., Brock-Utne J. G., Gaffin S. L., Wells M. T., Blake G. T. Strenuous exercise causes systemic endotoxemia. J Appl Physiol (1985) 1988 Jul;65(1):106–108. doi: 10.1152/jappl.1988.65.1.106. [DOI] [PubMed] [Google Scholar]
  5. Bouchard G., Carrillo M. C., Tuchweber B., Perea A., Ledoux M., Poulin D., Yousef I. M. Moderate long-term physical activity improves the age-related decline in bile formation and bile salt secretion in rats. Proc Soc Exp Biol Med. 1994 Sep;206(4):409–415. doi: 10.3181/00379727-206-43779. [DOI] [PubMed] [Google Scholar]
  6. Brouns F., Beckers E. Is the gut an athletic organ? Digestion, absorption and exercise. Sports Med. 1993 Apr;15(4):242–257. doi: 10.2165/00007256-199315040-00003. [DOI] [PubMed] [Google Scholar]
  7. Carrió I., Estorch M., Serra-Grima R., Ginjaume M., Notivol R., Calabuig R., Vilardell F. Gastric emptying in marathon runners. Gut. 1989 Feb;30(2):152–155. doi: 10.1136/gut.30.2.152. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Clausen J. P. Effect of physical training on cardiovascular adjustments to exercise in man. Physiol Rev. 1977 Oct;57(4):779–815. doi: 10.1152/physrev.1977.57.4.779. [DOI] [PubMed] [Google Scholar]
  9. Coenen C., Wegener M., Wedmann B., Schmidt G., Hoffmann S. Does physical exercise influence bowel transit time in healthy young men? Am J Gastroenterol. 1992 Mar;87(3):292–295. [PubMed] [Google Scholar]
  10. Colditz G. A., Cannuscio C. C., Frazier A. L. Physical activity and reduced risk of colon cancer: implications for prevention. Cancer Causes Control. 1997 Jul;8(4):649–667. doi: 10.1023/a:1018458700185. [DOI] [PubMed] [Google Scholar]
  11. Cordain L., Latin R. W., Behnke J. J. The effects of an aerobic running program on bowel transit time. J Sports Med Phys Fitness. 1986 Mar;26(1):101–104. [PubMed] [Google Scholar]
  12. D'Incà R., Varnier M., Mestriner C., Martines D., D'Odorico A., Sturniolo G. C. Effect of moderate exercise on Crohn's disease patients in remission. Ital J Gastroenterol Hepatol. 1999 Apr;31(3):205–210. [PubMed] [Google Scholar]
  13. Demers L. M., Harrison T. S., Halbert D. R., Santen R. J. Effect of prolonged exercise on plasma prostaglandin levels. Prostaglandins Med. 1981 Apr;6(4):413–418. doi: 10.1016/0161-4630(81)90073-2. [DOI] [PubMed] [Google Scholar]
  14. Donald I. P., Smith R. G., Cruikshank J. G., Elton R. A., Stoddart M. E. A study of constipation in the elderly living at home. Gerontology. 1985;31(2):112–118. doi: 10.1159/000212689. [DOI] [PubMed] [Google Scholar]
  15. Efremushkin G. G., Titova Z. A., Molchanov A. V., Nedoseko O. V., Burgsdorf O. E. Vliianie kompleksnogo lecheniia s primeneniem velotrenirovok so svobodnym vyborom parametrov nagruzki na gemodinamiku bol'nykh iazvennoi bolezn'iu. Ter Arkh. 1998;70(2):13–16. [PubMed] [Google Scholar]
  16. Everhart J. E., Go V. L., Johannes R. S., Fitzsimmons S. C., Roth H. P., White L. R. A longitudinal survey of self-reported bowel habits in the United States. Dig Dis Sci. 1989 Aug;34(8):1153–1162. doi: 10.1007/BF01537261. [DOI] [PubMed] [Google Scholar]
  17. Feldman M., Nixon J. V. Effect of exercise on postprandial gastric secretion and emptying in humans. J Appl Physiol Respir Environ Exerc Physiol. 1982 Oct;53(4):851–854. doi: 10.1152/jappl.1982.53.4.851. [DOI] [PubMed] [Google Scholar]
  18. Harris A., Lindeman A. K., Martin B. J. Rapid orocecal transit in chronically active persons with high energy intake. J Appl Physiol (1985) 1991 Apr;70(4):1550–1553. doi: 10.1152/jappl.1991.70.4.1550. [DOI] [PubMed] [Google Scholar]
  19. Jeukendrup A. E., Vet-Joop K., Sturk A., Stegen J. H., Senden J., Saris W. H., Wagenmakers A. J. Relationship between gastro-intestinal complaints and endotoxaemia, cytokine release and the acute-phase reaction during and after a long-distance triathlon in highly trained men. Clin Sci (Lond) 2000 Jan;98(1):47–55. [PubMed] [Google Scholar]
  20. Kadyrova R. Kh, Shakieva R. A. Dinamika izmenenii lipidnogo sostava zhelchi u bol'nykh alimentarnym ozhireniem pod vliianiem lecheniia. Ter Arkh. 1986;58(2):79–82. [PubMed] [Google Scholar]
  21. Karam S. E., Nies D. M. Student/staff collaboration: a pilot bowel management program. J Gerontol Nurs. 1994 Mar;20(3):32–40. doi: 10.3928/0098-9134-19940301-07. [DOI] [PubMed] [Google Scholar]
  22. Katschinski B. D., Logan R. F., Edmond M., Langman M. J. Physical activity at work and duodenal ulcer risk. Gut. 1991 Sep;32(9):983–986. doi: 10.1136/gut.32.9.983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Keeling W. F., Harris A., Martin B. J. Loperamide abolishes exercise-induced orocecal liquid transit acceleration. Dig Dis Sci. 1993 Oct;38(10):1783–1787. doi: 10.1007/BF01296099. [DOI] [PubMed] [Google Scholar]
  24. Kinnunen O. Study of constipation in a geriatric hospital, day hospital, old people's home and at home. Aging (Milano) 1991 Jun;3(2):161–170. doi: 10.1007/BF03323997. [DOI] [PubMed] [Google Scholar]
  25. Klein I., Reif S., Farbstein H., Halak A., Gilat T. Preillness non dietary factors and habits in inflammatory bowel disease. Ital J Gastroenterol Hepatol. 1998 Jun;30(3):247–251. [PubMed] [Google Scholar]
  26. Koffler K. H., Menkes A., Redmond R. A., Whitehead W. E., Pratley R. E., Hurley B. F. Strength training accelerates gastrointestinal transit in middle-aged and older men. Med Sci Sports Exerc. 1992 Apr;24(4):415–419. [PubMed] [Google Scholar]
  27. Lee I. M., Paffenbarger R. S., Jr Physical activity and its relation to cancer risk: a prospective study of college alumni. Med Sci Sports Exerc. 1994 Jul;26(7):831–837. [PubMed] [Google Scholar]
  28. Leitzmann M. F., Giovannucci E. L., Rimm E. B., Stampfer M. J., Spiegelman D., Wing A. L., Willett W. C. The relation of physical activity to risk for symptomatic gallstone disease in men. Ann Intern Med. 1998 Mar 15;128(6):417–425. doi: 10.7326/0003-4819-128-6-199803150-00001. [DOI] [PubMed] [Google Scholar]
  29. Leitzmann M. F., Rimm E. B., Willett W. C., Spiegelman D., Grodstein F., Stampfer M. J., Colditz G. A., Giovannucci E. Recreational physical activity and the risk of cholecystectomy in women. N Engl J Med. 1999 Sep 9;341(11):777–784. doi: 10.1056/NEJM199909093411101. [DOI] [PubMed] [Google Scholar]
  30. Liu F., Kondo T., Toda Y. Brief physical inactivity prolongs colonic transit time in elderly active men. Int J Sports Med. 1993 Nov;14(8):465–467. doi: 10.1055/s-2007-1021212. [DOI] [PubMed] [Google Scholar]
  31. Loudon C. P., Corroll V., Butcher J., Rawsthorne P., Bernstein C. N. The effects of physical exercise on patients with Crohn's disease. Am J Gastroenterol. 1999 Mar;94(3):697–703. doi: 10.1111/j.1572-0241.1999.00939.x. [DOI] [PubMed] [Google Scholar]
  32. Manousos O. N., Vrachliotis G., Papaevangelou G., Detorakis E., Doritis P., Stergiou L., Merikas G. Relation of diverticulosis of the colon to environmental factors in Greece. Am J Dig Dis. 1973 Mar;18(3):174–176. doi: 10.1007/BF01071969. [DOI] [PubMed] [Google Scholar]
  33. Markiewicz K., Lukin M. Maksymalne wydzielanie zoładkowe w czasie wysiłku fizycznego i restytucji u osob z przewlekła choroba wrzodowa dwunastnicy. Pol Arch Med Wewn. 1988 Jan;79(1):13–19. [PubMed] [Google Scholar]
  34. Mauriz J. L., Tabernero B., García-López J., Jorquera F., Villa J. G., González-Gallego J. Physical exercise and improvement of liver oxidative metabolism in the elderly. Eur J Appl Physiol. 2000 Jan;81(1-2):62–66. doi: 10.1007/PL00013798. [DOI] [PubMed] [Google Scholar]
  35. Meshkinpour H., Selod S., Movahedi H., Nami N., James N., Wilson A. Effects of regular exercise in management of chronic idiopathic constipation. Dig Dis Sci. 1998 Nov;43(11):2379–2383. doi: 10.1023/a:1026609610466. [DOI] [PubMed] [Google Scholar]
  36. Moses F. M., Brewer T. G., Peura D. A. Running-associated proximal hemorrhagic colitis. Ann Intern Med. 1988 Mar;108(3):385–386. doi: 10.7326/0003-4819-108-3-385. [DOI] [PubMed] [Google Scholar]
  37. Moses F. M. The effect of exercise on the gastrointestinal tract. Sports Med. 1990 Mar;9(3):159–172. doi: 10.2165/00007256-199009030-00004. [DOI] [PubMed] [Google Scholar]
  38. Neufer P. D., Young A. J., Sawka M. N. Gastric emptying during walking and running: effects of varied exercise intensity. Eur J Appl Physiol Occup Physiol. 1989;58(4):440–445. doi: 10.1007/BF00643522. [DOI] [PubMed] [Google Scholar]
  39. Nielsen P., Nachtigall D. Iron supplementation in athletes. Current recommendations. Sports Med. 1998 Oct;26(4):207–216. doi: 10.2165/00007256-199826040-00001. [DOI] [PubMed] [Google Scholar]
  40. Nieman D. C. Immune response to heavy exertion. J Appl Physiol (1985) 1997 May;82(5):1385–1394. doi: 10.1152/jappl.1997.82.5.1385. [DOI] [PubMed] [Google Scholar]
  41. O'Connor A. M., Johnston C. F., Buchanan K. D., Boreham C., Trinick T. R., Riddoch C. J. Circulating gastrointestinal hormone changes in marathon running. Int J Sports Med. 1995 Jul;16(5):283–287. doi: 10.1055/s-2007-973006. [DOI] [PubMed] [Google Scholar]
  42. Oettlé G. J. Effect of moderate exercise on bowel habit. Gut. 1991 Aug;32(8):941–944. doi: 10.1136/gut.32.8.941. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. Oktedalen O., Lunde O. C., Opstad P. K., Aabakken L., Kvernebo K. Changes in the gastrointestinal mucosa after long-distance running. Scand J Gastroenterol. 1992 Apr;27(4):270–274. doi: 10.3109/00365529209000073. [DOI] [PubMed] [Google Scholar]
  44. Oliveria S. A., Christos P. J. The epidemiology of physical activity and cancer. Ann N Y Acad Sci. 1997 Dec 29;833:79–90. doi: 10.1111/j.1749-6632.1997.tb48595.x. [DOI] [PubMed] [Google Scholar]
  45. Pahor M., Guralnik J. M., Salive M. E., Chrischilles E. A., Brown S. L., Wallace R. B. Physical activity and risk of severe gastrointestinal hemorrhage in older persons. JAMA. 1994 Aug 24;272(8):595–599. [PubMed] [Google Scholar]
  46. Pals K. L., Chang R. T., Ryan A. J., Gisolfi C. V. Effect of running intensity on intestinal permeability. J Appl Physiol (1985) 1997 Feb;82(2):571–576. doi: 10.1152/jappl.1997.82.2.571. [DOI] [PubMed] [Google Scholar]
  47. Persson P. G., Leijonmarck C. E., Bernell O., Hellers G., Ahlbom A. Risk indicators for inflammatory bowel disease. Int J Epidemiol. 1993 Apr;22(2):268–272. doi: 10.1093/ije/22.2.268. [DOI] [PubMed] [Google Scholar]
  48. Peters H. P., Akkermans L. M., Bol E., Mosterd W. L. Gastrointestinal symptoms during exercise. The effect of fluid supplementation. Sports Med. 1995 Aug;20(2):65–76. doi: 10.2165/00007256-199520020-00002. [DOI] [PubMed] [Google Scholar]
  49. Peters H. P., Bos M., Seebregts L., Akkermans L. M., van Berge Henegouwen G. P., Bol E., Mosterd W. L., de Vries W. R. Gastrointestinal symptoms in long-distance runners, cyclists, and triathletes: prevalence, medication, and etiology. Am J Gastroenterol. 1999 Jun;94(6):1570–1581. doi: 10.1111/j.1572-0241.1999.01147.x. [DOI] [PubMed] [Google Scholar]
  50. Peters H. P., Wiersma W. C., Akkermans L. M., Bol E., Kraaijenhagen R. J., Mosterd W. L., de Vries W. R., Wielders J. P. Gastrointestinal mucosal integrity after prolonged exercise with fluid supplementation. Med Sci Sports Exerc. 2000 Jan;32(1):134–142. doi: 10.1097/00005768-200001000-00020. [DOI] [PubMed] [Google Scholar]
  51. Peters H. P., Zweers M., Backx F. J., Bol E., Hendriks E. R., Mosterd W. L., de Vries W. R. Gastrointestinal symptoms during long-distance walking. Med Sci Sports Exerc. 1999 Jun;31(6):767–773. doi: 10.1097/00005768-199906000-00002. [DOI] [PubMed] [Google Scholar]
  52. ROWELL L. B., BLACKMON J. R., BRUCE R. A. INDOCYANINE GREEN CLEARANCE AND ESTIMATED HEPATIC BLOOD FLOW DURING MILD TO MAXIMAL EXERCISE IN UPRIGHT MAN. J Clin Invest. 1964 Aug;43:1677–1690. doi: 10.1172/JCI105043. [DOI] [PMC free article] [PubMed] [Google Scholar]
  53. Rao S. S., Beaty J., Chamberlain M., Lambert P. G., Gisolfi C. Effects of acute graded exercise on human colonic motility. Am J Physiol. 1999 May;276(5 Pt 1):G1221–G1226. doi: 10.1152/ajpgi.1999.276.5.G1221. [DOI] [PubMed] [Google Scholar]
  54. Rehrer N. J., Beckers E., Brouns F., Hoor ten F., Saris W. H. Exercise and training effects on gastric emptying of carbohydrate beverages. Med Sci Sports Exerc. 1989 Oct;21(5):540–549. [PubMed] [Google Scholar]
  55. Rehrer N. J., Janssen G. M., Brouns F., Saris W. H. Fluid intake and gastrointestinal problems in runners competing in a 25-km race and a marathon. Int J Sports Med. 1989 May;10 (Suppl 1):S22–S25. doi: 10.1055/s-2007-1024950. [DOI] [PubMed] [Google Scholar]
  56. Rehrer N. J., Meijer G. A. Biomechanical vibration of the abdominal region during running and bicycling. J Sports Med Phys Fitness. 1991 Jun;31(2):231–234. [PubMed] [Google Scholar]
  57. Rissanen A., Fogelholm M. Physical activity in the prevention and treatment of other morbid conditions and impairments associated with obesity: current evidence and research issues. Med Sci Sports Exerc. 1999 Nov;31(11 Suppl):S635–S645. doi: 10.1097/00005768-199911001-00024. [DOI] [PubMed] [Google Scholar]
  58. Ritland S., Foss N. E., Gjone E. Physical activity in liver disease and liver function in sportsmen. Scand J Soc Med Suppl. 1982;29:221–226. [PubMed] [Google Scholar]
  59. Robertson G., Meshkinpour H., Vandenberg K., James N., Cohen A., Wilson A. Effects of exercise on total and segmental colon transit. J Clin Gastroenterol. 1993 Jun;16(4):300–303. doi: 10.1097/00004836-199306000-00006. [DOI] [PubMed] [Google Scholar]
  60. Robinson R. J., Krzywicki T., Almond L., al-Azzawi F., Abrams K., Iqbal S. J., Mayberry J. F. Effect of a low-impact exercise program on bone mineral density in Crohn's disease: a randomized controlled trial. Gastroenterology. 1998 Jul;115(1):36–41. doi: 10.1016/s0016-5085(98)70362-2. [DOI] [PubMed] [Google Scholar]
  61. Schedl H. P., Maughan R. J., Gisolfi C. V. Intestinal absorption during rest and exercise: implications for formulating an oral rehydration solution (ORS). Proceedings of a roundtable discussion. April 21-22, 1993. Med Sci Sports Exerc. 1994 Mar;26(3):267–280. [PubMed] [Google Scholar]
  62. Shephard R. J., Shek P. N. Associations between physical activity and susceptibility to cancer: possible mechanisms. Sports Med. 1998 Nov;26(5):293–315. doi: 10.2165/00007256-199826050-00002. [DOI] [PubMed] [Google Scholar]
  63. Soffer E. E., Summers R. W., Gisolfi C. Effect of exercise on intestinal motility and transit in trained athletes. Am J Physiol. 1991 May;260(5 Pt 1):G698–G702. doi: 10.1152/ajpgi.1991.260.5.G698. [DOI] [PubMed] [Google Scholar]
  64. Soffer E. E., Wilson J., Duethman G., Launspach J., Adrian T. E. Effect of graded exercise on esophageal motility and gastroesophageal reflux in nontrained subjects. Dig Dis Sci. 1994 Jan;39(1):193–198. doi: 10.1007/BF02090082. [DOI] [PubMed] [Google Scholar]
  65. Sonnenberg A. Factors which influence the incidence and course of peptic ulcer. Scand J Gastroenterol Suppl. 1988;155:119–140. doi: 10.3109/00365528809096294. [DOI] [PubMed] [Google Scholar]
  66. Sonnenberg A. Occupational distribution of inflammatory bowel disease among German employees. Gut. 1990 Sep;31(9):1037–1040. doi: 10.1136/gut.31.9.1037. [DOI] [PMC free article] [PubMed] [Google Scholar]
  67. Suadicani P., Hein H. O., Gyntelberg F. Genetic and life-style determinants of peptic ulcer. A study of 3387 men aged 54 to 74 years: The Copenhagen Male Study. Scand J Gastroenterol. 1999 Jan;34(1):12–17. doi: 10.1080/00365529950172763. [DOI] [PubMed] [Google Scholar]
  68. Sullivan S. N., Wong C., Heidenheim P. Does running cause gastrointestinal symptoms? A survey of 93 randomly selected runners compared with controls. N Z Med J. 1994 Aug 24;107(984):328–331. [PubMed] [Google Scholar]
  69. Sutherland W. H., Nye E. R., Macfarlane D. J., Robertson M. C., Williamson S. A. Fecal bile acid concentration in distance runners. Int J Sports Med. 1991 Dec;12(6):533–536. doi: 10.1055/s-2007-1024729. [DOI] [PubMed] [Google Scholar]
  70. Sørensen V. Z., Olsen B. G., Binder V. Life prospects and quality of life in patients with Crohn's disease. Gut. 1987 Apr;28(4):382–385. doi: 10.1136/gut.28.4.382. [DOI] [PMC free article] [PubMed] [Google Scholar]
  71. Utter A. C., Goss F. L., Whitcomb D. C., Brown M. L., Pusateri J. P., Kriska A. M., Dasilva S. G., Robertson R. J. The effects of acute exercise on gallbladder function in an adult female population. Med Sci Sports Exerc. 1996 Mar;28(3):280–284. doi: 10.1097/00005768-199603000-00002. [DOI] [PubMed] [Google Scholar]
  72. Utter A. C., Whitcomb D. C., Nieman D. C., Butterworth D. E., Vermillion S. S. Effects of exercise training on gallbladder function in an obese female population. Med Sci Sports Exerc. 2000 Jan;32(1):41–45. doi: 10.1097/00005768-200001000-00007. [DOI] [PubMed] [Google Scholar]
  73. Van Erpecum K. J., Van Berge-Henegouwen G. P. Gallstones: an intestinal disease? Gut. 1999 Mar;44(3):435–438. doi: 10.1136/gut.44.3.435. [DOI] [PMC free article] [PubMed] [Google Scholar]
  74. Vandewalle H., Lacombe C., Lelièvre J. C., Poirot C. Blood viscosity after a 1-h submaximal exercise with and without drinking. Int J Sports Med. 1988 Apr;9(2):104–107. doi: 10.1055/s-2007-1024988. [DOI] [PubMed] [Google Scholar]
  75. Watkins J. B., 3rd, Crawford S. T., Sanders R. A. Chronic voluntary exercise may alter hepatobiliary clearance of endogenous and exogenous chemicals in rats. Drug Metab Dispos. 1994 Jul-Aug;22(4):537–543. [PubMed] [Google Scholar]
  76. Yiamouyiannis C. A., Martin B. J., Watkins J. B., 3rd Chronic physical activity alters hepatobiliary excretory function in rats. J Pharmacol Exp Ther. 1993 Apr;265(1):321–327. [PubMed] [Google Scholar]

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