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. 1989 Jul;33(7):1108–1110. doi: 10.1128/aac.33.7.1108

Penetration of cefuroxime into ventricular fluid in cerebrospinal fluid shunt infections.

M S Edwards 1, C J Baker 1, K M Butler 1, E O Mason Jr 1, J P Laurent 1, W R Cheek 1
PMCID: PMC176071  PMID: 2782860

Abstract

The penetration of intravenously administered cefuroxime into ventricular fluid was assessed in five pediatric patients with ventriculoperitoneal shunt infections and in one with a ventriculostomy infection. Patients received a total dose of 200 to 230 mg of cefuroxime per kg of body weight per day administered at 8-h intervals. Levels of cefuroxime in ventricular fluid ranged from 1.6 to 22.5 micrograms/ml and were associated with cerebrospinal fluid bactericidal titers ranging from less than 1:2 to 1:16 against infecting staphylococcal isolates. Five infections were cured with cefuroxime monotherapy. On the basis of MIC data, one patient had vancomycin substituted for cefuroxime and the infection was cured.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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