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. 1997 Feb;65(2):783–786. doi: 10.1128/iai.65.2.783-786.1997

Proteophosphoglycan secreted by Leishmania mexicana amastigotes causes vacuole formation in macrophages.

C Peters 1, Y D Stierhof 1, T Ilg 1
PMCID: PMC176125  PMID: 9009342

Abstract

The amastigote form of Leishmania mexicana parasites colonizes macrophage phagolysosomes and induces the enlargement of these compartments to form huge parasitophorous vacuoles. We report here that a purified secreted amastigote product, proteophosphoglycan, is a macromolecule which causes vacuolization of peritoneal macrophages in vitro. Secretion of this glycoconjugate by intracellular parasites may contribute to the expansion of phagolysosomal compartments in infected cells.

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Selected References

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