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. 1997 Feb;65(2):794–797. doi: 10.1128/iai.65.2.794-797.1997

Identification of a frameshift mutation resulting in premature termination and loss of cell wall anchoring of the PAc antigen of Streptococcus mutans GS-5.

Y Murakami 1, Y Nakano 1, Y Yamashita 1, T Koga 1
PMCID: PMC176127  PMID: 9009344

Abstract

Most strains of Streptococcus mutans possess a 190-kDa protein antigen (PAc) on their cell surfaces, while strain GS-5 produces extracellularly a 155-kDa PAc protein. The pac gene of strain GS-5 consists of 3,477 bp and codes for a protein of 1,158 amino acids. One insertion of an adenine into the 3,469th, 3,470th, or 3,471st position from the start codon results in a frameshift mutation at codon 1157 with subsequent termination after 3 additional codons.

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Selected References

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