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. 1984 Sep;26(3):401–404. doi: 10.1128/aac.26.3.401

Evaluation of Sch 29482 in experimental syphilis and comparison with penicillin G benzathine in disseminated disease and localized infection.

R E Baughn, C Adams, D M Musher
PMCID: PMC176178  PMID: 6508267

Abstract

The present study was designed to assess the in vivo activity of Sch 29482, a new penem antibiotic, against disseminated and localized Treponema pallidum infections in rabbits. Animals were inoculated either intravenously or intradermally. Randomized groups then received 25 or 50 mg of Sch 29482 per kilogram of body weight twice a day for 7 days, two weekly injections of 200,000 U of penicillin G benzathine for comparative purposes, or no antibiotic therapy. In both infection models, striking differences were noted between the untreated control rabbits and rabbits receiving penicillin G benzathine or high-dose Sch 29482. Intravenously infected rabbits did not develop disseminated lesions or orchitis, and chancres produced by intradermal infection regressed and healed rapidly after both treatment regimens. Infectivity studies also suggested that high-dose Sch 29482 and penicillin G benzathine were effective since the testes and lymph nodes of treated animals were free of infectious organisms. Treatment of animals with the lower dose of Sch 29482 represented borderline or suboptimal therapy, with a failure rate of one in four for each infection model.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baughn R. E., Musher D. M., Adams C. B., Knox J. M. Evaluation of rosaramicin phosphate in treatment of experimental syphilis in rabbits. Antimicrob Agents Chemother. 1981 Jan;19(1):117–121. doi: 10.1128/aac.19.1.117. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Baughn R. E., Musher D. M. Isolation and preliminary characterization of circulating immune complexes from rabbits with experimental syphilis. Infect Immun. 1983 Nov;42(2):579–584. doi: 10.1128/iai.42.2.579-584.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Brown R. M., Wise R., Andrews J. M. Sch 29482--a novel penem antibiotic: an in-vitro comparison of its activity with other beta-lactams. J Antimicrob Chemother. 1982 Feb;9 (Suppl 100):17–23. doi: 10.1093/jac/9.suppl_c.17. [DOI] [PubMed] [Google Scholar]
  4. Dillon J. R., Pauzé M., Yeung H., Bezanson G. S. Comparison of the in-vitro activity of Sch 29482 with thirteen other beta-lactam antibiotics against Neisseria meningitidis and Neisseria gonorrhoeae (including penicillinase-producing isolates). J Antimicrob Chemother. 1982 Feb;9 (Suppl 100):175–180. doi: 10.1093/jac/9.suppl_c.175. [DOI] [PubMed] [Google Scholar]
  5. Hare R. S., Miller G. H., Naples L., Sabatelli F., Loebenberg D., Waitz J. A. Sch 29482, a new penem antibiotic: evaluation of in-vitro activity and effect of test conditions. J Antimicrob Chemother. 1982 Feb;9 (Suppl 100):7–16. doi: 10.1093/jac/9.suppl_c.7. [DOI] [PubMed] [Google Scholar]
  6. Lukehart S. A., Baker-Zander S. A., Holmes K. K. Efficacy of aztreonam in treatment of experimental syphilis in rabbits. Antimicrob Agents Chemother. 1984 Mar;25(3):390–391. doi: 10.1128/aac.25.3.390. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Lukehart S. A., Baker-Zander S. A., Lloyd R. M., Sell S. Effect of cortisone administration on host-parasite relationships in early experimental syphilis. J Immunol. 1981 Oct;127(4):1361–1368. [PubMed] [Google Scholar]
  8. Ovcinnikov N. M., Korbut S. E., Bednova V. N., Timcenko G. F., Milonova T. I. Long-term results of penicillin treatment of early and late forms of syphilis in the rabbit. Br J Vener Dis. 1973 Oct;49(5):413–419. doi: 10.1136/sti.49.5.413. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Phillips I., King A., Shannon K., Warren C. Sch 29482: in-vitro antibacterial activity and susceptibility to beta-lactamases. J Antimicrob Chemother. 1982 Feb;9 (Suppl 100):25–30. doi: 10.1093/jac/9.suppl_c.25. [DOI] [PubMed] [Google Scholar]
  10. Rein M. F. Biopharmacology of syphilotherapy. J Am Vener Dis Assoc. 1976 Dec;3(2 Pt 2):109–127. [PubMed] [Google Scholar]
  11. Tight R. R., White A. C. Quantitative microhaemagglutination assay for Treponema pallidum antibodies in experimental syphilis. Br J Vener Dis. 1980 Oct;56(5):291–296. doi: 10.1136/sti.56.5.291. [DOI] [PMC free article] [PubMed] [Google Scholar]

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