Abstract
Aztreonam, 1 g intramuscularly, was compared with spectinomycin, 2 g intramuscularly, for uncomplicated gonorrhea. There were no failures with either drug. For aztreonam, there were 26 urethral, 3 rectal, and 3 endocervical sites that were infected. Aztreonam in a single dose of 1 g intramuscularly is satisfactory therapy for uncomplicated urethral gonorrhea in men and may be effective for rectal and endocervical infection as well.
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Selected References
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- Breuer H., Cimarusti C. M., Denzel T., Koster W. H., Slusarchyk W. A., Treuner U. D. Monobactams--structure-activity relationships leading to SQ 26,776. J Antimicrob Chemother. 1981 Dec;8 (Suppl E):21–28. doi: 10.1093/jac/8.suppl_e.21. [DOI] [PubMed] [Google Scholar]
- Brown R. M., Wise R., Andrews J. M. Sch 29482--a novel penem antibiotic: an in-vitro comparison of its activity with other beta-lactams. J Antimicrob Chemother. 1982 Feb;9 (Suppl 100):17–23. doi: 10.1093/jac/9.suppl_c.17. [DOI] [PubMed] [Google Scholar]
- Fainstein V., Weaver S., Bodey G. P. Comparative in vitro study of SQ26,776. Antimicrob Agents Chemother. 1982 Feb;21(2):294–298. doi: 10.1128/aac.21.2.294. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jacobus N. V., Ferreira M. C., Barza M. In vitro activity of azthreonam, a monobactam antibiotic. Antimicrob Agents Chemother. 1982 Nov;22(5):832–838. doi: 10.1128/aac.22.5.832. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Miller L. K., Sanchez P. L., Berg S. W., Kerbs S. B., Harrison W. O. Effectiveness of aztreonam, a new monobactam antibiotic, against penicillin-resistant gonococci. J Infect Dis. 1983 Sep;148(3):612–612. doi: 10.1093/infdis/148.3.612. [DOI] [PubMed] [Google Scholar]
- Neu H. C., Labthavikul P. In vitro activity and beta-lactamase stability of a monobactam, SQ 26,917, compared with those of aztreonam and other agents. Antimicrob Agents Chemother. 1983 Aug;24(2):227–232. doi: 10.1128/aac.24.2.227. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Swabb E. A., Sugerman A. A. Review of single- and multiple-dose pharmacokinetics of the monobactam, aztreonam (SQ 26,776) in healthy subjects. Chemotherapy. 1983;29(5):313–321. doi: 10.1159/000238214. [DOI] [PubMed] [Google Scholar]