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. 1975 Jul;27(4):528–542.

Gammaglobulin groups of the Khoisan peoples of Southern Africa: evidence for polymorphism for a Gm1,5,13,14,21 haplotype among the San.

A G Steinberg, T Jenkins, G T Nurse, H C Harpending
PMCID: PMC1762806  PMID: 808124

Abstract

The Gm and Inv types were determined for eight San (Bushman) populations, two Khoikhoi (Hottentot) populations, one Coloured population, 112 San families in which the genotypes of the parents could be unambiguously determined, and for 65 San families in which the genotype of one or both parents could not be determined with certainty. The population and family data establish that the haplotype array of the San is composed of Gm1,21, Gm1,13, Gm1,5,13,14, and Gm1,5,13,14,21; Gm1,5,6 and Gm1,5,6,14 are also present but may have been acquired through admixture with Negroes. The Gm1,5,13,14,21 haplotype has not been found to be polymorphic in any other population. The haplotype array of the Khoikhoi is composed of Gm1,2,21, Gm1,13, and Gm1,5,13,14; Gm1,5,6 and Gm1,5,6,14 are also present but, as in the case of the San, may be due to admixture. The San and Khoikhoi differ from each other in that the former have the Gm1,21 and Gm1,5,13,14,21 haplotypes not present in the latter, and the Khoikhoi have the Gm1,2,21 haplotype not present in the San. These three haplotypes and Gm1,13 serve to distinguish the Khoisan people from other African peoples.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Jenkins T., Steinberg A. G. Some serum protein polymorphisms in Kalahari bushmen and Bantu: gamma globulins, haptoglobins, and transferrins. Am J Hum Genet. 1966 Jul;18(4):399–407. [PMC free article] [PubMed] [Google Scholar]
  2. Jenkins T., Zoutendyk A., Steinberg A. G. Gammaglobulin groups (Gm and Inv) of various Southern African populations. Am J Phys Anthropol. 1970 Mar;32(2):197–218. doi: 10.1002/ajpa.1330320206. [DOI] [PubMed] [Google Scholar]
  3. Kurczynski T. W., Steinberg A. G. A general program for maximum likelihood estimation of gene frequencies. Am J Hum Genet. 1967 Mar;19(2):178–179. [PMC free article] [PubMed] [Google Scholar]
  4. Milstein C. P., Steinberg A. G., McLaughlin C. L., Solomon A. Amino acid sequence change associated with genetic marker Inv(2) of human immunoglobulin. Nature. 1974 Mar 8;248(5444):160–161. doi: 10.1038/248160a0. [DOI] [PubMed] [Google Scholar]
  5. STEINBERG A. G., GOLDBLUM R. A GENETIC STUDY OF THE ANTIGENS ASSOCIATED WITH THE GM(B) FACTOR OF HUMAN GAMMA GLOBULIN. Am J Hum Genet. 1965 Mar;17:133–147. [PMC free article] [PubMed] [Google Scholar]
  6. STEINBERG A. G., MATSUMOTO H. STUDIES ON THE GM, INV, HP AND TF SERUM FACTORS OF JAPANESE POPULATIONS AND FAMILIES. Hum Biol. 1964 May;36:77–85. [PubMed] [Google Scholar]
  7. Steinberg A. G. Gm and Inv allotypes of some Sidamo Ethiopians. Am J Phys Anthropol. 1973 Nov;39(3):403–408. doi: 10.1002/ajpa.1330390308. [DOI] [PubMed] [Google Scholar]

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