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. 1975 May;27(3):419–429.

Chromosome aberrations induced in vitro by low doses of radiation: nondisjunction in lymphocytes of young adults.

I A Uchida 1, C P Lee 1, E M Byrnes 1
PMCID: PMC1762864  PMID: 803021

Abstract

Epidemiological studies suggest radiation exposure as a cause of meiotic non-disjunction in humans, but experimental evidence with cytological proof has been lacking. Our results indicate that mitotic nondisjunction of lymphocyte chromosomes can also be induced by exposure to a low dose of radiation. Abnormal segregation can be induced not only when the cells are irradiated but also when nonirradiated cells are incubated with irradiated cell-free plasma or serum. The X and no. 21 chromosomes appear particularly susceptible to nondisjunction.

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Selected References

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